Director, Portfolio Decision Sciences in London

GSK is seeking a Director, Portfolio Decision Sciences to partner with the Head, Portfolio Decision Sciences, Oncology in supporting GSK’s Oncology and broader Pharmaceutical portfolio across the entire R&D lifecycle – from preclinical research through late‑stage clinical development. In this influential role, you will work directly with project teams and governance boards to evaluate investment opportunities in areas of high uncertainty and limited data. You will play a pivotal part in guiding technical progression and investment decisions through systematic risk assessment, probabilistic evaluation, and rigorous economic analysis (e.g., ROI, NPV). Your insights will inform key decision‑making bodies including the Portfolio Investment Board (PIB), Development Review Board (DRB) and Research Unit Investment Boards.

You will shape strategically differentiated options, drive challenging conversations with senior leaders, and leverage cutting‑edge data and technology trends to enable high‑quality portfolio decision making. The ideal candidate is an intellectually curious portfolio expert with deep R&D experience, a passion for innovation, and the ability to navigate and influence broadly across the Oncology and R&D ecosystems at GSK.

In this role, you will provide leadership across Decision Sciences and Portfolio Management for the Pharmaceutical portfolio, including Oncology and non‑Oncology assets. You will support high‑impact decisions at senior leadership levels, ensuring objectivity, cross‑portfolio consistency, and strategic context. Specific responsibilities include:

• Guiding project teams across the R&D lifecycle (including BD opportunities) using strategic decision frameworks, probability‑of‑success elicitation, and economic evaluations (ROI, NPV), facilitating decision making and generating project‑and portfolio‑level insights.
• Delivering objective project assessments for R&D investment decisions at Research Unit governance bodies, and the Portfolio Investment Board (PIB).
• Providing clear, rigorous recommendations to governance chairs based on detailed value‑risk analyses, option evaluations, resource considerations, and risk‑discharge points.
• Leading portfolio‑ or indication‑level assessments to inform senior leaders on prioritisation decisions across scientific, commercial, operational, strategic and financial dimensions.
• Supporting the biannual dynamic Portfolio Review (dPR) for Oncology, ensuring refreshed project assessments and surfacing emerging investment opportunities.
• Collaborating across finance, portfolio management, strategy, operations, and Research Units to recommend short‑ and long‑term focus areas and enable optimal resource deployment.
• Driving portfolio management excellence by monitoring the external environment, evaluating innovative portfolio approaches, and proposing use cases applicable to GSK.
• Enhancing the development and deployment of advanced analytics, including AI and machine learning, to elevate decision‑making quality across teams and senior leadership.

We are looking for professionals with these required skills and experiences to achieve our goals:

• Bachelor’s degree in Science or Business.
• PhD, MD, or advanced scientific/decision sciences degree preferred.
• Demonstrated experience in pharmaceutical, healthcare, or related industries.
• Strong understanding of R&D processes, ideally with experience supporting or leading drug‑development teams.
• Proven track record of independently delivering complex projects.
• Experience navigating cross‑functional teams and enabling change.
• High learning agility; ability to facilitate complex scientific, technical, value, and resourcing discussions.
• Ability to translate detailed scientific and technical insights into concise, impactful recommendations.
• Strong relationship‑building skills to become a trusted strategic partner to project teams and senior leaders.
• Ability to manage multiple projects, priorities, and fast‑paced decision cycles.

Closing Date for Applications – 10 February 2026 (EOD)

Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Please note if you require adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at where you can also request a call.