Principal Scientist, Inflammation Research in Oxford

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We are seeking an experienced immunologist to lead a talented team of scientists supporting the development of novel biologic therapies in autoimmune disease. The successful candidate will conduct and oversee in vitro and in vivo pharmacology studies supporting both lead and early discovery programs in immunology, and will require rigour in delivering data packages for progression to development. They will collaborate across functions to pursue creative science, in the service of discovering novel medicines that impact patients’ lives.

Additional Key Responsibilities

• Mentor a lab-based scientific team, advancing their projects and careers.
• Serve as a scientific and technical thought leader throughout the Research organization.
• Collaborate across functions to guide interdisciplinary projects, with experts in immunology, protein engineering, chemistry, translational medicine, biomarkers and clinical development.
• Identify project risks and mitigate effectively, while communicating with project teams and other leaders.
• Proactively ideate to accelerate early-stage discovery activities, enhance understanding of disease mechanisms, and develop new technologies and novel targeting modalities.
• Design and implement rigorous in vitro assays, based on thorough literature review, to support the development of therapeutic antibodies in autoimmune disease.
• Work with internal teams and contract research organisations to plan and co-ordinate in vivo models for DMPK and efficacy.
• Develop endpoint analysis, including ex vivo profiling, to better understand drug mechanism of action.
• Develop expertise in relevant scientific fields and the external landscape, including the scientific literature, conference proceedings, and competitive programs.
• Contribute expertise to multi-disciplinary due diligence teams to evaluate and recommend partnerships and acquisitions.
• Contribute to research reports, INDs, and patent filings.
• Establish an external presence through peer-reviewed publications, conference presentations, and external collaborations.

Knowledge, Experience and Skills

• PhD and 5+ years of experience (immunology, drug discovery, target identification and technology development), with industry experience highly preferred.
• Strong track record of impact in scientific field, including first- or senior-author publications in peer-reviewed journals and conference presentations.
• Strong knowledge base in basic immunology and pathogenesis of autoimmune disease.
• Broad technical skillset of cutting-edge methods and models of immunology, in vitro and in vivo.
• Demonstrated success in leading research teams to productive, creative, data-driven decisions.
• Team-centric mindset, with proven managerial excellence and ability to motivate skilled team members from diverse backgrounds.
• Excellent communication and interpersonal skills.