Important notice to applicants
Genomics is aware of an individual falsely presenting themselves as a representative of Genomics and attempting to recruit candidates on our behalf.
Please be vigilant when responding to recruitment approaches. Genuine communications from Genomics will come from an email address ending in @genomics.com. Emails or other communications relating to recruitment that come from individuals or organisations using a different email domain may not be genuine.
If you receive a recruitment communication and you are unsure, please do not provide personal information. Instead, please reach out to us directly via our form on the Contact Us page.
Why work with us?
The growth of Genomics is partnered with the personal growth of our people. We ensure that all employees have the tools, technologies, benefits, and support systems to develop and flourish. We offer a competitive package of benefits, training opportunities, and initiatives to ensure our employees thrive.
Be part of a globally diverse team
Our workforce operates across the UK and US from offices based in Oxford, UK, London, UK Cambridge, UK, and North Carolina, US.
Our diversity and multinationalism, with our people hailing from over 30 countries, helps to bring together the best minds to harness the power of genomics and transform healthcare and drug discovery.
Perks and benefits
Life insurance
Charities trust
Pension
Group income protection
Cycle to work scheme
Critical illness cover
Private medical cover
Bank your Bank Holidays
A collaborative andsocial culture
Social events
Training and development opportunities
Organised sports activities
Join our team
Application Security Engineer
Location
London; Oxford
Location Type
Hybrid
Department
Location: Oxford or London (Hybrid)
The Mission: Why We Exist
Genomics is a science-led transatlantic TechBio combining large-scale genetic and health data with proprietary analytics to accelerate drug discovery and advance predictive, preventative healthcare. We are united by a single vision to help people live longer, healthier lives, using the power of genomics.
Genomics aims to help people live longer, healthier lives in two ways: super-charging drug discovery and development for novel treatments with our AI-enabled advanced genetic analytics platform, and by helping people understand their personal risk of common chronic diseases through polygenic risk scores - giving doctors and health systems the chance to get the right people into the right prevention, screening and treatment programmes at the right time.
Role Purpose
Genomic data is some of the most sensitive data there is, and our customers trust us with it. As Senior Application Security Engineer on Mystra, you'll own application security end-to-end across multi-tenant, trillion-row-scale, AI-enabled data platforms.
You'll lead threat modelling and design review with product teams, build the tooling and patterns that make secure codet, and find and fix the vulnerabilities that slip through. You'll do it with security-focused AI tooling, steered by your own expert judgement and intuition, to keep Genomics secure against state-of-the-art threats.
A Day in the Life
Leading threat modelling and design reviews for new products and infrastructure, and defining the security invariants every team builds against: tenant isolation, authentication and authorisation, secrets, least privilege, and trust boundaries
Building the libraries, patterns, and CI/CD guardrails that make the secure way the easy way, and deciding what is enforced versus advised
Building and tuning AI tooling for code analysis, triage, and remediation, and deciding where its output can be trusted and where it must be verified
Hunting for vulnerabilities through code review, testing, and proof-of-concept exploits, then running the disclosure programme and driving every finding through to a verified fix
Securing our agentic and AI surfaces, from prompt injection and tool boundaries to delegated credentials and tenant-scoped access, and proving the controls hold under adversarial testing
Working as an embedded, trusted partner to product teams, SRE, detection and response, the data platform team, and the MystraAI / ML team, unblocking rather than gating
Who You Are
Experience within application security in production. You've found and fixed exploitable bugs in software you were responsible for, through threat modelling, secure design, code review, and proof-of-concept exploitation across web services, APIs, and data-serving interfaces. Triaging scanner output doesn't count
Production-quality software engineering in at least one mainstream language (such as Python, Go, or TypeScript), and you can read several. You've built and operated security or developer tooling in CI/CD pipelines, such as static and dependency analysis, secrets detection, or policy-as-code, and engineers actually adopted it
Hands-on depth securing multi-tenant systems on a major cloud. We run on AWS (RDS, EC2, S3, EKS, Batch), and comparable GCP or Azure depth transfers. You know tenant isolation, IAM and least privilege, secrets management, Kubernetes and container security, and the trust boundaries between services
Daily use of frontier AI models for code analysis, vulnerability triage, remediation drafting, and research, with sharp judgement about where they're reliable and where they mislead. You've built or tuned LLM-driven tooling rather than only used a chat interface, and you understand the attack surface it introduces
Experience running, or being core to, a vulnerability disclosure or bug bounty programme and the remediation lifecycle behind it, covering severity, prioritisation, SLAs, root cause, and systemic fixes. You've also worked application-layer incidents alongside detection and response, using security telemetry and SIEM data as evidence
Risk-led judgement. You know which designs need deep review, which findings matter and which are noise, and you make accepted risk explicitly so leadership can decide with open eyes
Clear communication. You explain risk and trade-offs precisely to engineers, product, and leadership, write guidance people actually use, and mentor others to grow security capability across teams
Your Package
We are committed to providing a transparent, supportive, and rewarding work environment.
Compensation & Growth
Competitive Reward: Salaries are externally benchmarked annually to ensure market-aligned compensation.
Clear Career Path: A straightforward, open progression framework means you'll always know the path to promotion and how to achieve your next career goal.
Continuous Learning: Including external courses and a wide library of L&D materials, because your growth is our success.
Holiday: 25 days annual leave, plus bank holidays, plus an extra 3-day company-wide shutdown at year-end.
Financial & Health Security: Robust benefits including a market-leading pension scheme, comprehensive private health insurance for you and your family with NO excess, critical illness, and life assurance.
Enhanced Leave: Enhanced paid family leave to support all new parents.
Hybrid Working
Truly Inclusive Time Off: Our 'Bank Your Bank Holiday' program allows you to exchange public holidays for dates that hold personal or cultural significance to you.
Vibrant Social Culture: From regular Town Halls and team picnics to organised sports events, our social committee ensures frequent opportunities to connect and celebrate.
Green Commute: Cycle-to-Work scheme and convenient office locations near major transport hubs.
Ready to Build the Future?
We are dedicated to creating a diverse environment and are proud to be an equal-opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Genomics politely requests no contact from recruitment agencies. We do not accept speculative CVs from recruitment agencies nor accept the fees associated with them.
Contact us at talent@genomics.com or connect with us on LinkedIn.
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Application Security Engineer in Oxford employer: Genomics PLC
Genomics plc is an exceptional employer, offering a dynamic work culture that fosters innovation and collaboration in the rapidly evolving field of genomics. With a strong focus on employee growth, we provide ample opportunities for professional development and the chance to work alongside industry leaders in a supportive environment. Located in a vibrant area, our team enjoys a balance of challenging projects and a commitment to work-life harmony, making it a truly rewarding place to advance your career.
