Principal Technical Project Manager ( we have office locations in Cambridge, Leeds & London)

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS's world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.

Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK's position as the best place to discover, prove and benefit from genomic innovations. We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

We are seeking a Principal Technical Project Manager to guide the delivery of key infrastructure, platform, and cloud initiatives at Genomics England. In this role, you will work closely with engineering, product, architecture, security, and assurance teams to achieve consistent, high-quality outcomes in a complex, regulated environment.

You will support the Service Owner by coordinating technical activity across squads and helping establish effective oversight of contractors, ensuring smooth collaboration and delivery.

Everyday responsibilities include:

• Own end-to-end delivery of technical workstreams within programmes, ensuring milestones, budgets, and OKRs are achieved.
• Partner with Product Managers and Service Owners to validate requirements and align delivery plans with strategic objectives.
• Develop and track detailed delivery plans, proactively managing progress and escalating risks or delays where required.
• Maintain and actively manage RAID logs (Risks, Actions, Issues, Dependencies) to support transparent programme oversight.
• Produce clear status reports and contribute to programme board updates to support informed decision-making.
• Establish effective governance and ensure compliance with cybersecurity, data protection, regulatory, and IT standards.
• Facilitate clear communication across delivery teams and stakeholders, including external partners, ensuring alignment and timely updates.
• Lead cross-functional contributors without direct line authority, resolving issues and driving decisions to maintain delivery momentum.

Skills and experience for success:

• Confidently manage projects while proactively identifying, tracking and resolving risks and issues to keep delivery on track.
• Comfortable communicating with both technical and non-technical audiences, ensuring everyone stays informed and aligned.
• Good understanding of commercial drivers and financial considerations when making project decisions.
• Build positive relationships with stakeholders, keeping them engaged and supported throughout the project lifecycle.
• Able to make well-judged decisions and escalate appropriately when needed to maintain progress and manage risks.
• Skilled at translating technical topics into clear, accessible language for non-technical stakeholders.
• Experience working within Agile delivery environments, including Kanban or Scrum.
• Familiarity with the following technologies: AWS ecosystem, including core infrastructure services such as EC2, S3, RDS and IAM; understanding of AWS architecture tools and services such as Lambda, EKS, VPC and Direct Connect; experience or awareness of operational and infrastructure-as-code tools including CloudFormation, Terraform and CloudWatch; exposure to AWS data and analytics services such as Glue, Redshift and Step Functions.

Whilst Project Management certifications are desirable, we are mostly interested in your experience.

Additional Information:

• Salary from: £77,000
• Closing date for applications - Saturday 21st March

Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we're continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including:

• Generous Leave: 30 days' holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
• Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
• Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), Life Assurance (3x salary), and a Give As You Earn scheme.
• Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
• Recognition & Rewards: Employee recognition programme and referral scheme.
• Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.

Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background.

Genomics England's policies of non-discrimination and equity will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor. Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity.

We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us.

Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However, this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to, however, some of our roles require full time on site attendance e.g., lab teams, reception team.

As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare.