Principal Technical Project Manager

We are seeking a Principal Technical Project Manager to help deliver and enhance modern on-premise and cloud-based infrastructure supporting world-leading genomics diagnostics and research. In this role, you will work closely with the Scalable Service Lead and leadership team to guide multiple interdependent technical workstreams, ensuring delivery aligns with programme objectives, governance frameworks, and PMO standards. You will collaborate across squads, suppliers, and partners, while supporting the Service Owner in coordinating technical platform delivery and managing third-party contributions. This senior role suits someone with strong technical understanding, excellent stakeholder engagement skills, and experience delivering complex platforms in regulated or data-intensive environments, with a collaborative and inclusive approach to delivery.

Responsibilities

• Lead end-to-end delivery of key technical areas within the programme, taking ownership while fostering a collaborative, supportive delivery environment.
• Partner with the Product Manager and/or Service Owner to validate and agree requirements, ensuring alignment with timelines, budgets, and OKRs.
• Establish and maintain delivery plans, tracking progress and communicating clearly where adjustments or support are needed.
• Proactively identify and resolve issues, working closely with teams to remove blockers and enable successful outcomes.
• Create and manage RAID (Risks, Actions, Issues, and Dependencies) logs, regularly reviewing and coordinating follow-up actions.
• Produce clear, concise status updates and contribute to programme and board-level reporting where required.
• Support structured and inclusive decision-making processes, ensuring the right stakeholders are engaged at the right time.
• Apply appropriate governance to meet internal and external standards, including cybersecurity, data protection, data quality, and regulatory requirements.
• Ensure transparent, thoughtful communication so delivery teams understand priorities, timelines, and expectations, while keeping stakeholders informed.
• Build positive relationships with internal and external stakeholders, managing escalations constructively and facilitating respectful conflict resolution when needed.
• Project, risk, and issue management with a proactive and solutions-focused approach.

Qualifications

• Strong communication skills, engaging effectively with both technical and non-technical audiences.
• Commercial awareness and financial understanding to support informed decision-making.
• Stakeholder management, building trusted relationships across teams and leadership levels.
• Confident decision-making with sound judgement on escalation and risk management.
• Ability to translate complex technical concepts into clear, accessible language for non-technical stakeholders.
• Collaborative approach to problem-solving, balancing delivery priorities with business needs.

Technology Exposure

• AWS ecosystem, including core infrastructure services such as EC2, S3, RDS and IAM.
• Understanding of AWS architecture tools and services such as Lambda, EKS, VPC and Direct Connect.
• Experience or awareness of operational and infrastructure-as-code tools including CloudFormation, Terraform and CloudWatch.
• Exposure to AWS data and analytics services such as Glue, Redshift and Step Functions.

Benefits

• Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
• Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
• Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), life assurance (3x salary), and a Give As You Earn scheme.
• Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
• Recognition & Rewards: Employee recognition programme and referral scheme.
• Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.

About Genomics England

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future. Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations. We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

Equal Opportunity and Diversity

Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background. Genomics England’s policies of non-discrimination and equity will be applied fairly to all people, regardless of age, disability, gender identity or re-assignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor. Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity. We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us. Reasonable adjustments can be requested at interview stage if you have a disability or long-term health condition which may impact on your ability to perform at an interview. Each adjustment requested is dependent upon your condition and how this would affect you in an interview. As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare. If you do not disclose a conviction that is identified on a DBS check, this may result in an offer of employment being withdrawn. This information may be shared with those internally who have a legitimate interest in the hiring process. Under the Rehabilitation of Offenders Act 1974, if you have an unspent criminal conviction and/or unspent conditional caution to declare, please disclose. We are committed to diversity and inclusion and will use your answers to anonymised questions to track and report on our progress in attracting and hiring a diverse workforce. Your answers are not visible to recruiters or hiring managers and are not used in the selection process.