Principal Project Manager (we have office locations in Leeds, London & Cambridge)

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.

Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations. We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

We are looking for a Principal Project Manager to join the Office of the Chief Technology & Product Officer (CTPO). This is an exciting opportunity to shape and deliver high-impact technology and product initiatives that support our wider mission. You will bring clarity, structure, and momentum to complex projects, helping teams work together effectively and ensuring strong governance across a diverse portfolio.

Everyday responsibilities include:

• Manage complex projects end to end, ensuring successful delivery, by managing planning, reporting, and end-to-end risk and issue management with a structured, and consistent approach.
• Build strong, trusted relationships with senior leaders, Service Management, Product, Service Design, and suppliers to enable effective collaboration and shared outcomes.
• Provide oversight across the CTPO portfolio, strengthening governance, improving visibility, and supporting informed decision-making.
• Coordinate programme and governance boards, ensuring reporting, escalation, and updates are clear, timely, and transparent for all stakeholders.

Skills and experience for success:

• Experience leading complex projects in large, matrixed environments.
• A collaborative approach and the ability to build trusted relationships with senior stakeholders and executive leaders.
• A strong track record of delivering end-to-end programmes that create meaningful and lasting impact.
• Confidence in setting up and managing project governance, and risk management across complex delivery environments.
• The ability to bring structure, clarity, and calm to fast-moving and evolving portfolios.
• Strong communication skills, with the ability to turn complexity into clear and useful insight for a range of audiences.

Whilst Project Management certifications are desirable, we are mostly interested in your experience.

Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we’re continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including:

• Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
• Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
• Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), Life Assurance (3x salary), an Electric Vehicle salary sacrifice scheme and a Give As You Earn scheme.
• Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
• Recognition & Rewards: Employee recognition programme and referral scheme.
• Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.

Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background.

Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity. We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us.

Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However, this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to, however, some of our roles require full time on site attendance e.g., lab teams, reception team.

As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare.