At a Glance
- Tasks: Drive the development of novel anti-cancer therapeutics through innovative lab-based research.
- Company: Genome Therapeutics Ltd, a pioneering company in preclinical drug discovery.
- Benefits: Competitive salary, hands-on experience, and opportunities for professional growth.
- Other info: Join a dynamic team in Cambridge and contribute to impactful cancer research.
- Why this job: Make a real difference in cancer treatment while working with cutting-edge technologies.
- Qualifications: PhD in life sciences and over 3 years in small molecule drug discovery.
The predicted salary is between 40000 - 55000 £ per year.
Genome Therapeutics Ltd (GTx) is seeking a lab-based cell and molecular biologist with experience in preclinical drug discovery to drive the development of our novel anti-cancer therapeutics. The ideal candidate will contribute biological data across GTx’s ongoing projects by applying comprehensive expertise in mechanistic cancer biology to characterise the mode of action (MoA) and pharmacodynamic (PD) biomarker responses of our assets and identifying disease positioning opportunities.
Location: This is an on-site position based at the GTx labs in Cambridge, UK.
Key responsibilities
- Develop and run mechanistic cell biological studies to characterise the MoA of novel compounds and support PD biomarker identification and characterisation.
- Develop and validate patient selection biomarker hypotheses to establish disease positioning opportunities.
Essential Skills / Experience
- Excellent skills in a broad range of cell and molecular biology techniques including mammalian cell culture (cancer and non-cancer cell lines, isogenics), Western blot, immunofluorescence microscopy and/or high throughput/high content imaging, flow cytometry (cell cycle/cell fate), monotherapy and combination viability assays, deployment of siRNA and CRISPR technologies, stable/transient transfection.
- Strong track record of using a range of methods to characterise pharmacological and genetic modulation of cancer pathways, genome stability mechanisms and/or DNA damage response biology.
- Proven experience of delivering impactful high quality data packages related to MoA, PD biomarker identification, translational path, and line of sight.
- Robust understanding of cancer biology.
- Expertise in running cell-based compound-sensitive assays using fluorescence and/or luminescence technologies.
- Identification, validation and optimisation of antibodies for cell-based assays.
- Proficiency in data carpentry, analysis and visualisation.
- Ability to work independently as well as part of a team in an organised and methodical fashion.
- Ability to troubleshoot experiments independently.
- Excellent communication and presentation skills.
- Excellent attention to detail.
- Keeping accurate laboratory records.
- High level of IT literacy.
- Flexible approach to change.
- PhD in a life science subject.
- >3 years of experience of small molecule drug discovery in an industrial setting.
Desirable Skills / Experience
- Understanding of DNA damage response biology.
- Experience with CRISPR and cell panel screening.
- Experience with a range of therapeutic targeting modalities.
- Experience with genomic, transcriptomic and proteomic interrogation of in vitro and ex vivo samples.
- Experience with developing, troubleshooting and running cell-based assays in 96/384WP formats.
- Proficient in use of compound dispensing equipment.
- Experience managing externalised studies at contract research organisations.
To apply send your CV together with a cover letter outlining how your skills and experience make you a suitable candidate for this role to recruitment@genometx.com quoting reference: 0006.
Cell and molecular biologist employer: Genome Therapeutics
Genome Therapeutics Ltd (GTx) is an exceptional employer located in the vibrant city of Cambridge, UK, offering a dynamic work environment that fosters innovation and collaboration in the field of cancer therapeutics. With a strong commitment to employee development, GTx provides ample opportunities for professional growth through hands-on experience in cutting-edge research, while promoting a culture of teamwork and open communication. Employees benefit from working alongside leading experts in the industry, contributing to meaningful projects that aim to make a significant impact on patient outcomes.
StudySmarter Expert Advice🤫
We think this is how you could land Cell and molecular biologist
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, attend relevant events, and engage with professionals on platforms like LinkedIn. We all know that sometimes it’s not just what you know, but who you know that can help you land that dream job.
✨Tip Number 2
Prepare for interviews by practising common questions and showcasing your expertise in cell and molecular biology. We recommend doing mock interviews with friends or mentors to boost your confidence and refine your answers.
✨Tip Number 3
Showcase your skills through a portfolio! If you’ve got data packages or research projects that highlight your experience in drug discovery, put them together. We love seeing tangible evidence of your work when you apply through our website.
✨Tip Number 4
Follow up after interviews! A quick thank-you email can go a long way in keeping you top of mind. We appreciate candidates who show enthusiasm and professionalism, so don’t hesitate to express your interest in the role.
We think you need these skills to ace Cell and molecular biologist
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience in cell and molecular biology, especially in preclinical drug discovery. We want to see how your skills align with the key responsibilities mentioned in the job description.
Craft a Compelling Cover Letter:Your cover letter should tell us why you're the perfect fit for this role. Use it to showcase your understanding of cancer biology and how your past experiences have prepared you for this position at GTx.
Showcase Your Skills:Don’t just list your skills; demonstrate them! Include specific examples of techniques you've mastered, like CRISPR or flow cytometry, and how you've applied them in your previous roles. We love seeing real-world applications!
Apply Through Our Website:While you can send your application via email, we encourage you to apply through our website for a smoother process. It helps us keep track of your application and ensures you don’t miss any important updates!
How to prepare for a job interview at Genome Therapeutics
✨Know Your Science
Brush up on your knowledge of cancer biology and the specific techniques mentioned in the job description. Be ready to discuss your experience with mammalian cell culture, Western blotting, and any other relevant methods. This shows you’re not just familiar with the terms but can apply them practically.
✨Prepare for Technical Questions
Expect questions that dive deep into your technical skills, especially around pharmacological modulation and biomarker identification. Think of specific examples from your past work where you successfully characterised MoA or developed assays. Use the STAR method (Situation, Task, Action, Result) to structure your answers.
✨Showcase Your Data Skills
Since data analysis and visualisation are key parts of this role, be prepared to discuss how you've handled data in previous projects. Bring examples of how you’ve used data carpentry to draw meaningful conclusions and how it impacted your research outcomes.
✨Demonstrate Teamwork and Independence
This position requires both independent work and collaboration. Share experiences where you’ve successfully worked in a team setting as well as instances where you took the lead on a project. Highlight your ability to troubleshoot and adapt to changes, which is crucial in a lab environment.
