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- Tasks: Lead cancer biology research and develop genomic biomarkers for innovative therapeutics.
- Company: Genome Therapeutics Ltd is a dynamic company focused on cutting-edge drug discovery.
- Benefits: Gain hands-on experience in genomics and early drug discovery in a collaborative environment.
- Why this job: Join a fast-paced team making a real impact in cancer treatment and research.
- Qualifications: PhD in cancer biology with 10+ years of relevant industry experience required.
- Other info: This is an on-site role based in Cambridge, UK.
The predicted salary is between 43200 - 72000 £ per year.
Job Description
Job Summary/Experience:
Genome Therapeutics Ltd (GTx) is seeking an industry experienced cancer biologist, with lab based experience in pre-clinical drug discovery, to lead mechanism and genomic biomarker development for novel therapeutics exploiting G-quadruplex binding molecules. The candidate will have a PhD in cancer biology and 10 years or more of relevant experience, with background knowledge/experience of DNA damage and genome instability mechanisms. The ideal candidate will have experience of line management and experience in the design and execution of hypothesis testing experiments using state of the art microscopy, molecular biology and genomics based methods. Previous experience of biomarker co-development will be an advantage.
GTx is a fast paced multidisciplinary company, offering training and experience in genomics, computational biology, early drug discovery and clinical studies.
Location: This is an on-site position based at the GTx labs in Cambridge UK.
Essential Skills/Experience:
● A PhD with experience in cancer biology and relevant experience in the DNA damage/genome instability, or genomic biomarker development.
● Previous experience in the biotechnology or pharmaceutical industry, especially within oncology.
● Leadership in the design of cell and molecular biology studies to support biomarker development and mechanism of action.
● Leadership in the design and execution of biomarker target validation experiments in PDXO and PDX systems in the lab and with external providers.
● Identification and engagement of key opinion leader external collaborations as needed to achieve project goals.
● Establishment of strategic internal resources such as internal isogenic and cell line backgrounds for screens
● Design of functional genetics strategies such as combinatorial CRISPR screens, for target credentialing in cancer models
● Self-sufficiency in basic computational/statistical analysis of experimental data
● Record and analyze experimental data accurately and efficiently, maintaining detailed records and documentation.
● Adhere to safety protocols and guidelines at all times, including proper handling and disposal of hazardous materials.
● Excellent organizational skills and attention to detail.
● Effective communication and teamwork abilities.
● Ability to work independently with minimal supervision and prioritize tasks effectively.
● Commitment to upholding quality standards, safety protocols, and regulatory compliance.
Desirable Skills/Experience:
● Proficiency in statistical/computational analysis of chemical and functional screen data to be self-sufficient in interpretation.
● Experience with tumour model systems, including isogenic knockouts, organoids and/or PDX systems.
● Experience in the design and use of CRISPR functional genetics screening approaches and chemical library screening approaches will be an advantage.
Cancer Biologist employer: Genome Therapeutics
Contact Detail:
Genome Therapeutics Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Cancer Biologist
✨Tip Number 1
Network with professionals in the oncology and biotechnology fields. Attend relevant conferences or seminars where you can meet industry leaders and discuss your expertise in cancer biology and drug discovery.
✨Tip Number 2
Engage with online communities and forums related to cancer research and genomics. Sharing your insights and asking questions can help you connect with potential collaborators and showcase your knowledge.
✨Tip Number 3
Consider reaching out directly to current employees at Genome Therapeutics Ltd. on platforms like LinkedIn. A friendly message expressing your interest in their work can lead to valuable insights about the company culture and expectations.
✨Tip Number 4
Stay updated on the latest advancements in cancer biology and genomic biomarker development. Being well-informed will not only enhance your discussions during interviews but also demonstrate your commitment to the field.
We think you need these skills to ace Cancer Biologist
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your PhD in cancer biology and relevant experience in DNA damage and genome instability. Emphasise any leadership roles you've held, especially in designing and executing experiments related to biomarker development.
Craft a Compelling Cover Letter: In your cover letter, explain why you're passionate about cancer biology and how your experience aligns with the role at Genome Therapeutics Ltd. Mention specific projects or achievements that demonstrate your expertise in pre-clinical drug discovery and genomic biomarker development.
Highlight Relevant Skills: Clearly outline your skills in microscopy, molecular biology, and genomics-based methods. If you have experience with CRISPR screening or tumour model systems, make sure to include that as well, as it will strengthen your application.
Showcase Collaboration Experience: Since the role involves engaging with key opinion leaders and external collaborations, provide examples of past collaborative projects. Highlight your effective communication and teamwork abilities to show you can thrive in a multidisciplinary environment.
How to prepare for a job interview at Genome Therapeutics
✨Showcase Your Expertise
Make sure to highlight your PhD and any relevant experience in cancer biology, particularly focusing on DNA damage and genome instability. Be prepared to discuss specific projects you've worked on that demonstrate your knowledge and skills in these areas.
✨Demonstrate Leadership Skills
Since the role involves leading studies and managing teams, be ready to share examples of your leadership experience. Discuss how you've designed and executed experiments, and how you’ve engaged with external collaborators to achieve project goals.
✨Familiarise Yourself with GTx's Work
Research Genome Therapeutics Ltd and their focus on G-quadruplex binding molecules. Understanding their current projects and challenges will allow you to tailor your responses and show genuine interest in the company’s mission.
✨Prepare for Technical Questions
Expect to answer technical questions related to molecular biology, genomics, and experimental design. Brush up on your knowledge of CRISPR techniques and biomarker development, as well as any computational analysis methods you’ve used in past research.