At a Glance
- Tasks: Lead in vivo pharmacology strategies for innovative oncology projects.
- Company: Genome Therapeutics, a pioneering biopharmaceutical company in Cambridge.
- Benefits: Competitive salary, inclusive culture, and opportunities for professional growth.
- Other info: Join a diverse team committed to equal opportunities and impactful science.
- Why this job: Make a real difference in cancer treatment through cutting-edge research.
- Qualifications: Ph.D. in relevant field with extensive experience in oncology pharmacology.
Department
Early Oncology Discovery / Biotherapeutics
Reports To
Head of Research and Development
Location
Central Cambridge; full-time onsite
Position Summary
We are seeking a highly driven, translational scientist to lead in vivo pharmacology at GTx. The successful candidate will be responsible for designing and executing in vivo strategies which will include efficacy, PK/PD and exploratory safety profiling for multiple modalities in oncology. The ideal candidate brings a proven track record of advancing novel small molecules and bioconjugates from early hit-to-lead through lead optimisation, culminating in the successful delivery of multiple Development Candidates (DCs) and IND filings.
Key Responsibilities
- Design and oversee integrated pharmacology strategies connecting in vitro cellular potency with in vivo target engagement, tumor regression, and safety margins.
- Co-author and defend comprehensive DC nomination packages, providing the biological, pharmacological, and early safety rationale for clinical advancement.
- Direct the selection, development, and execution of translationally relevant in vivo oncology models (e.g., CDX, PDX, syngeneic, and genetically engineered mouse models).
- Establish robust in vivo credentialing studies to validate mechanism of action, demonstrate monotherapy or combination efficacy, and evaluate acquired resistance mechanisms.
- Oversee the development of pharmacodynamic (PD) biomarker assays (e.g., target occupancy, downstream signaling inhibition) to prove target modulation in vivo correlates with tumor stasis or regression.
DMPK & PK/PD Translation
- Contribute to the DMPK strategy to ensure chemical leads possess the necessary ADME properties for the intended route of administration
- Integrate pharmacokinetic data with pharmacodynamic readouts to build robust PK/PD models.
- Define minimum effective concentrations, target exposure thresholds (AUC), and optimal dosing schedules to guide human dose projections.
Operational Execution
- Manage external contract research organizations (CROs) and academic collaborators to execute complex in vivo efficacy and DMPK studies efficiently and rigorously.
- Ensure all in vivo research meets internal QA standards and external IACUC protocols, animal welfare regulations, and rigorous data integrity standards for regulatory submissions.
Candidate Qualifications & Experience
Required Qualifications
- Education:Ph.D. or equivalent experience in Pharmacology, Cancer Biology, Physiology, Toxicology, or a closely related discipline.
- Track Record:Documented success in delivering multiple small molecule oncology programs to Development Candidate (DC) status and contributing directly to successful IND filings.
- Experience:10+ years of biopharmaceutical industry experience in early discovery and translational research, with at least 5 years in a senior leadership role managing pharmacology or DMPK programs.
- Core Technical expertise:
- Oncology in vivo pharmacology, including hands-on experience with diverse tumor models and a thorough understanding of tumor microenvironment (TME) biology.
- Strong command of small molecule DMPK principles, metabolite identification, and PK/PD mathematical modeling.
- Practical experience designing and interpreting exploratory toxicology studies to define safety margins.
- Demonstrated ability to work hand-in-glove with medicinal chemists, utilizing biological data to directly inform SAR and chemical design iterations.
- Leadership Skills:Proven track record of managing external CROs, with the ability to inspire scientists and drive rigorous, data-driven decision-making.
Preferred Attributes
- Expertise across small molecule modalities, such as targeted protein degraders, covalent inhibitors, or allosteric modulators.
- Experience with bioconjugates/ADC
- Strong executive presence with experience of presentations to scientific advisory boards, executive level management, and cross functional contribution to regulatory agencies (e.g., pre-IND meetings) interactions.
Equal Opportunities & Right to Work
Genome Therapeutics is an equal opportunities employer. We welcome applications from all qualified candidates, regardless of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation and we make recruitment decisions based on merit.
Applicants must have the right to work in the UK at the time of application; unfortunately, we are unable to offer sponsorship for this role.
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In vivo Pharmacologist (Oncology) in Cambridge employer: Genome Therapeutics
At GTx, we pride ourselves on being an exceptional employer, fostering a collaborative and innovative work culture in the heart of Central Cambridge. Our commitment to employee growth is evident through tailored development opportunities and a supportive environment that encourages scientific exploration and advancement in oncology research. Join us to be part of a dynamic team dedicated to making meaningful contributions to cancer therapeutics while enjoying the vibrant community and resources that Cambridge has to offer.
StudySmarter Expert Advice🤫
We think this is how you could land In vivo Pharmacologist (Oncology) in Cambridge
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Some tips for your application 🫡
Showcase Your Relevant Experience:When applying for a role in the pharmaceutical industry, it's crucial to highlight any relevant experience you have. Whether that's internships, lab work, or even related coursework, make sure to weave this into your CV and cover letter. We want to see how your background aligns with the role you're applying for at Genome Therapeutics!
Emphasise Your Understanding of Regulations:The pharmaceutical industry is heavily regulated, so it's important to indicate your familiarity with industry standards and regulations. In your cover letter, mention any training or certifications you've received that are relevant, or discuss projects where you’ve navigated compliance. This will show Genome Therapeutics that you're not just a fit for the job but also a safety-conscious candidate!
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Convey Your Passion for the Industry:In your cover letter, express why you are passionate about working in the pharmaceutical sector. Whether it’s your desire to contribute to groundbreaking drug research or improve patient outcomes, let it shine through! At Genome Therapeutics, we value candidates who are truly enthusiastic about their work—you might just stand out from the crowd.
How to prepare for a job interview at Genome Therapeutics
✨Understand the Science
Make sure you brush up on key pharmaceutical concepts and recent developments in the industry. You might get asked some technical questions during the interview at Genome Therapeutics that show your grasp of drug development processes or regulatory requirements, so be ready to discuss them clearly.
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If you have any hands-on experience or internships in a laboratory setting, be sure to highlight these in your responses. Think about the projects you worked on, the methodologies you used, and the impact you made. It's all about telling a story that connects your background to the role you're applying for.
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In a full-time pharmaceutical role, understanding the regulatory landscape is crucial. Prepare for situational questions that may test your problem-solving skills concerning compliance and safety standards. You could be asked how you'd handle a hypothetical issue regarding a drug’s market release, so think through your approach.
