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- Tasks: Join a dynamic team to explore cancer evolution and develop innovative treatments.
- Company: The Francis Crick Institute, Europe's largest biomedical research hub.
- Benefits: Competitive salary, generous leave, health support, and professional development opportunities.
- Other info: Inclusive workplace with diverse teams and excellent career growth potential.
- Why this job: Make a real impact in cancer research and collaborate with top scientists.
- Qualifications: PhD or nearing completion in relevant fields; experience in cancer biology or computational analysis.
The predicted salary is between 47500 - 47500 £ per year.
Working pattern: This is a full-time, 4 year fixed term position on Crick terms and conditions of employment.
Salary: From £47,500 with benefits, subject to skills and experience.
Application closing date: 3rd of May at 23.59pm
About us: The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world‑class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state‑of‑the‑art infrastructure, cutting‑edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high‑quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role: The Research Group is looking for a creative and enthusiastic Postdoctoral Fellow to join the C Swanton Cancer Evolution and Genome Instability Laboratory. This lab studies how cancers evolve in the body to spread and become resistant to therapy and find new ways to treat them more effectively.
The Project: Lung cancer remains one of the most pressing public health concerns worldwide, demanding innovative research to address its complexities and challenges. Our research presents two distinct yet intertwined project directions for a postdoc candidate. We are seeking applications from candidates with a broad range of competencies. Firstly, we are committed to advancing our understanding of the biology of lung tumour evolution based around analysis of next‑generation sequencing (NGS) data and the tumour microenvironment from the TRACERx longitudinal lung cancer programme. Our aim is to trace the intricate evolutionary trajectories of lung tumours across space and time. This work will unveil the key drivers of cancer progression, immune resistance mechanisms, and potential vulnerabilities within the tumour landscape. In parallel, our second research direction investigates the role of non‑mutagenic carcinogens in lung cancer initiation. By identifying common inflammatory pathways across different tissues, we aspire to identify actionable targets within these pathways suitable for therapeutic intervention to prevent the onset of cancer.
What you will be doing: Working within the multi‑disciplinary team of clinicians, bioinformaticians and bench scientists in the Swanton lab, and collaborating with groups at the Francis Crick Institute and beyond, including academic and industry partners. Driving the project forward using relevant experimental and/or computational approaches. Keeping up to date with the relevant literature in the field of cancer biology. Attending and reporting research results at regular group meetings. Contributing to the dissemination of scientific results by means of writing papers for publication and presenting orally and in poster form at national and international meetings. Lead their own projects and contribute to other projects on a collaborative basis.
About you: We are seeking applications from both experimental and computational candidates for this role. PhD, or in the final stages of PhD completion in cancer biology / evolutionary biology / cancer immunology / genomics or other relevant discipline. Good knowledge and experience in at least one of the following: cancer biology / cancer immunology / epithelial cell biology / evolutionary biology / genomics / statistics / mathematics or machine learning. Technical qualifications: For bench scientist: expertise in mouse models of cancer, functional in vitro assays, experience with alveolar Type 2 organoid cell culture, experience with tissue histology/flow cytometry methods, familiarity with CRISPR/Cas9 or other genetic perturbation approaches. For computational scientist: previous experience with NGS data analysis; fluency in R, Python or C++. Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals.
About Working at the Crick: Our values are bold, open, and collegial. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident employer and want to ensure that everyone can apply and be part of our recruitment processes and we’ll make reasonable adjustments if you need them – just let us know when you apply.
What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well‑being and development. Applicants for this role will be eligible for sponsorship to work in the UK. Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well‑being: 24/7 GP consultation services. Occupational health services and mental health support programmes. Eye care vouchers and discounted healthcare plans. Work‑Life Balance: Back‑up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups’ support, community and inclusive social events. Perks: Discounted gym memberships, bike‑to‑work scheme, and shopping discounts. Subsidised on‑site restaurant and social spaces for team interaction.
Please note you must meet the essential criteria listed within the Role Profile to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.
Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory employer: Francis Crick Institute
Contact Detail:
Francis Crick Institute Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory
✨Tip Number 1
Network like a pro! Reach out to current or former employees at the Crick Institute on LinkedIn. A friendly chat can give us insider info about the lab culture and maybe even a referral.
✨Tip Number 2
Prepare for your interview by diving deep into the latest research in cancer evolution and genome instability. Show us you’re not just passionate but also knowledgeable about the field!
✨Tip Number 3
Practice your presentation skills! You might need to present your research ideas during the interview, so make sure you can communicate your thoughts clearly and confidently.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows us you’re serious about joining our team.
We think you need these skills to ace Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory
Some tips for your application 🫡
Tailor Your Application: Make sure to customise your CV and cover letter for the Postdoctoral Fellow role. Highlight your relevant experience in cancer biology or genomics, and show us how your skills align with our lab's focus on lung cancer research.
Showcase Your Research: Don’t forget to include details about your previous research projects and any publications. We love seeing a track record of scientific contributions, so let us know how you've made an impact in your field!
Be Clear and Concise: When writing your application, keep it straightforward and to the point. Use clear language to describe your qualifications and experiences, making it easy for us to see why you’d be a great fit for our team.
Apply Through Our Website: We encourage you to submit your application through our website. It’s the best way to ensure your application gets to us directly, and you’ll find all the necessary details there to help you along the way!
How to prepare for a job interview at Francis Crick Institute
✨Know Your Research
Before the interview, dive deep into the latest research from the C Swanton Cancer Evolution and Genome Instability Laboratory. Familiarise yourself with their projects, especially those related to lung cancer evolution and NGS data analysis. This will not only show your genuine interest but also help you engage in meaningful discussions during the interview.
✨Showcase Your Skills
Be ready to discuss your technical qualifications in detail. Whether you're an experimental or computational candidate, prepare examples of your past work that highlight your expertise in cancer biology, genomics, or relevant methodologies. Bring along any publications or manuscripts to demonstrate your track record in research.
✨Collaborative Mindset
The Crick Institute values collaboration, so be prepared to discuss how you've worked in multi-disciplinary teams before. Share specific examples of how you contributed to group projects and how you can bring that collaborative spirit to the lab. Highlight your ability to communicate effectively with clinicians, bioinformaticians, and other scientists.
✨Ask Insightful Questions
Prepare thoughtful questions about the lab's current projects, future directions, and the team dynamics. This shows that you're not just interested in the position but are also keen on contributing to the lab's goals. Asking about their approach to tackling challenges in cancer research can spark a great conversation.