This position is open exclusively to current Northeastern University Co-Op students.
Work Period: January 2027 to June 2027. This is a full-time, 40 hours per week position with 5 days in office.
About Tild e
Tilde Bio, Inc. (FL110) is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. Our goal is to create programmable biological measurement systems capable of extracting rich molecular information from single-molecule interactions.
We believe nanopores generate a high-dimensional measurement of molecular identity and behavior that remains largely untapped. Unlocking that information requires new computational approaches - ones that don't yet exist - built by people who are comfortable working at the edge of what's known. At Tilde, you will work alongside scientists and engineers from diverse disciplines to help define how a new generation of biological sensing systems extract meaning from the physical world.
Tilde is backed by Flagship Pioneering, which brings the long-term vision and resources needed to build platforms that don't fit neatly into existing categories.
About Flagship Pioneering
Tilde, Inc. was founded by Flagship Pioneering's venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com .
Flagship Pioneering Co-Op Program
Welcome to Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You'll join fellow peers across our ecosystem of companies and learning firsthand how we build first-in-category companies. You'll have access to enrichment sessions , a dedicated professional development track , and a mentor that help guide you toward your next step. By the end, you will carry on a meaningful project outcome , a genuine network , and a front-row view of how Flagship pioneer new ventures that change the world.
About the Role/Team
We are seeking a motivated Master's-level C o- O p to join our Bioconjugation C hemistry team in developing novel bioconjugation chemistries for site-selective protein modification. You will design, synthesize, and evaluate new reactive handles and conjugation strategies, and apply them directly to conjugate proteins with small molecules, linkers, payloads, and other functional moieties. You will carry synthesized reagents through protein conjugation and characterization, with the goal of expanding the toolkit for building next-generation protein conjugates. This is a hands-on laboratory role with real scientific ownership, working closely with chemists, protein engineers, and nanopore scientists.
Responsibilities
- Design and execute experiments to discover and optimize new bioconjugation reactions on proteins and peptides, targeting native residues , termini, and/or genetically encoded or non-canonical handles
- Synthesize small-molecule reagents, linkers, and probes, including purification and structural characterization
- Screen reaction conditions under biocompatible conditions and assess kinetics, selectivity, and yield
- Characterize protein conjugates using intact-protein LC-MS and related methods to determine purity, conjugation efficiency , and site selectivity
- Evaluate conjugate stability and the impact of modification on protein structure and function
- Maintain accurate, detailed records in an electronic lab notebook
- Analyze data, summarize findings, and present results at team meetings
- Contribute to a culture of safe laboratory practice and scientific rigor
Qualifications
- Currently pursuing an M.S. in Chemistry, Chemical Biology, Biochemistry, or a closely related field
- Strong foundation in organic synthesis, including multistep synthesis, purification, and characterization
- Hands-on experience with analytical techniques such as NMR and LC-MS , and is able to extract structural information from spectra
- Working knowledge of protein chemistry, including handling, purification, and buffer considerations
- Previous research or industry experience
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Tilde Bio: Bioconjugation Chemistry Co-Op in Cambridge employer: Flagship Pioneering Co-Op Program
Quotient Therapeutics is an exceptional employer that fosters a collaborative and innovative work culture, ideal for those passionate about advancing drug development in a genetics-based biotech environment. Employees benefit from comprehensive growth opportunities, including professional development programmes and mentorship, while working in a dynamic setting that values creativity and strategic thinking. Located in a vibrant area, the company offers a unique chance to contribute to meaningful projects that have a real impact on patient outcomes.
Contact Details:
Flagship Pioneering Co-Op Program Recruitment Team
