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- Tasks: Lead innovative research in TCR cell therapy, designing assays and mentoring junior scientists.
- Company: Join a cutting-edge biotech in Oxfordshire focused on next-gen immunotherapies for solid tumours.
- Benefits: Enjoy a competitive salary, benefits package, and the chance to work in a dynamic environment.
- Why this job: Be part of groundbreaking research that makes a real impact in oncology and cell therapy.
- Qualifications: PhD in relevant fields with 3 years of experience in TCR-T or CAR-T therapies required.
- Other info: Collaborate with diverse teams and stay at the forefront of scientific advancements.
The predicted salary is between 42500 - 57500 £ per year.
Senior Scientist TCR Cell Therapy (Oncology) Location: Oxfordshire Department: R&D Oncology / Cell Therapy Salary: £50,000£60,000 pa plus Benefits About Us Executive Recruitment have again been retained by this innovative biotech based in Oxfordshire specialising in engineered T-cell receptor (TCR-T) therapies targeting solid tumours. Their mission is to deliver next-generation immunotherapies with enhanced specificity and clinical impact. To that end we are looking to speak with Senior Scientists within this niche area of expertise. More about the role below. Key Responsibilities Lead design and execution of in?vitro and ex?vivo functional assays to evaluate engineered TCR-T constructs (cytotoxicity, proliferation, cytokine release). Develop and optimise immunophenotyping methods using multi-colour flow cytometry, ELISA/ELISPOT, T-cell isolation, expansion, and killing assays. Conduct preclinical study designs, including lentiviral/retroviral transduction of T cells, gene editing (e.g., CRISPR/Cas9), and cell therapy process development. Interpret experimental data, drive go/no-go decision-making, and present findings internally and externally. Mentor junior scientists, maintain lab quality standards, and collaborate with cross-functional teams (bioinformatics, translational research, in?vivo). Stay updated on TCR-T and CAR-T advances, incorporating new technologies and publications into R&D strategy. Technical Skills Fluency in multi-parameter flow cytometry (including immunophenotyping and high-content analysis) Robust experience with functional T-cell assays (cytotoxicity, proliferation, cytokine release, ELISPOT) Molecular biology expertise: gene editing (CRISPR), stable cell line generation, gene expression analysis Familiarity with pre-clinical in?vivo or translational assay systems (desirable) Professional Skills Strong analytical capabilities with data interpretation and statistical presentation Excellent written/oral communication. Comfortable presenting to multidisciplinary audiences and publishing scientific outputs Proven ability to mentor and manage junior staff Collaborative mindset within cross-functional, fast-paced R&D teams Education & Experience PhD in Immunology, Cell Biology, Molecular Biology, or related field (MSc industry experience may be considered) 3 years post-doctoral or industrial experience working with TCR-T or CAR-T cell therapies Experience with viral vectorbased transduction, T-cell isolation/expansion, gene editing, and primary human cell assays If you have the skills, experience and desire to part of this industry leading company then please do not hesitate to apply. TPBN1_UKTJ
Senior Scientist - TCR Cell Therapy (Oncology) employer: Executive Recruit
Contact Detail:
Executive Recruit Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist - TCR Cell Therapy (Oncology)
✨Tip Number 1
Network with professionals in the field of TCR cell therapy and oncology. Attend relevant conferences, webinars, or workshops to meet potential colleagues and learn about the latest advancements. This can help you gain insights into the company culture and possibly get a referral.
✨Tip Number 2
Stay updated on the latest research and developments in TCR-T and CAR-T therapies. Follow key publications and thought leaders in the field. Being knowledgeable about current trends will not only prepare you for interviews but also demonstrate your passion for the role.
✨Tip Number 3
Prepare to discuss specific projects or experiences that align with the job responsibilities. Think about how your previous work with functional assays, gene editing, or flow cytometry can contribute to the company's goals. Tailoring your discussion points will make you stand out.
✨Tip Number 4
Practice your presentation skills, as you'll likely need to present findings to multidisciplinary teams. Consider creating a mock presentation based on your past research. This will help you feel more confident and articulate during the actual interview process.
We think you need these skills to ace Senior Scientist - TCR Cell Therapy (Oncology)
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in TCR-T or CAR-T cell therapies. Emphasise your technical skills, such as flow cytometry and functional T-cell assays, to align with the job requirements.
Craft a Compelling Cover Letter: Write a cover letter that showcases your passion for oncology and immunotherapy. Mention specific projects or experiences that demonstrate your expertise in the field and how they relate to the company's mission.
Highlight Your Research Experience: In your application, detail your research experience, particularly any work involving gene editing, preclinical studies, or mentoring junior scientists. This will show your capability to lead and innovate in the role.
Proofread and Edit: Before submitting your application, thoroughly proofread your documents. Check for clarity, grammar, and spelling errors to ensure a professional presentation that reflects your attention to detail.
How to prepare for a job interview at Executive Recruit
✨Showcase Your Technical Expertise
Be prepared to discuss your experience with multi-parameter flow cytometry and functional T-cell assays in detail. Highlight specific projects where you successfully developed or optimised these methods, as this will demonstrate your hands-on skills and knowledge in the field.
✨Prepare for Data Interpretation Questions
Since the role involves interpreting experimental data, practice explaining your past findings and decision-making processes. Be ready to discuss how you approached data analysis and what statistical methods you employed, as this will showcase your analytical capabilities.
✨Demonstrate Leadership and Mentoring Skills
As a Senior Scientist, you'll likely be mentoring junior staff. Prepare examples of how you've successfully guided others in previous roles, focusing on your collaborative mindset and ability to manage teams effectively within a fast-paced R&D environment.
✨Stay Updated on Industry Advances
Familiarise yourself with the latest developments in TCR-T and CAR-T therapies. Being able to discuss recent publications or technological advancements during your interview will show your commitment to staying at the forefront of the field and integrating new knowledge into your work.
