At a Glance
- Tasks: Lead innovative gene therapy research and assess its impact on neurodegenerative diseases.
- Company: Join the UK Dementia Research Institute, a leader in dementia research and innovation.
- Benefits: Enjoy 41 days of holiday, gym access, and a supportive work environment.
- Other info: We celebrate diversity and encourage applications from underrepresented groups.
- Why this job: Make a real difference in neuroscience while working with cutting-edge technology and diverse teams.
- Qualifications: PhD in biomedical sciences or relevant experience; in vivo work and molecular biology skills required.
The predicted salary is between 36000 - 60000 € per year.
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Organisation/Company UK Dementia Research Institute Research Field Neurosciences Researcher Profile First Stage Researcher (R1) Positions PhD Positions Country United Kingdom Application Deadline 30 Jul 2025 - 23:59 (Europe/London) Type of Contract Temporary Job Status Full-time Hours Per Week 36.5 Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number B02-09007 Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill the major knowledge gap in our basic understanding of the diseases that cause dementia.
Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.
About us
The Research Department of Neurodegenerative Disease is recognized as internationally leading in the study of neurodegenerative diseases causing dementia and related disorders. The Department has a strong focus on mechanistic dissection of genetic, molecular cellular and neuropathological processes which underlie neurodegeneration in particular diseases and across the neurodegeneration spectrum.
The Isaacs Lab investigates the molecular mechanisms underlying frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We are particularly interested in the C9orf72 gene (a common cause of both FTD and ALS) and the CHMP2B gene, (a rare cause of FTD), and use a multidisciplinary approach including disease modelling in mice, Drosophila, primary neurons and iPS cell-derived neurons. By combining these model systems with analysis of patient tissue we ensure the relevance of our work to the disease process we are studying. We are also working to translate our research findings into potential therapies using gene therapy and high-throughput screening approaches.
About the role
We have developed a novel dual-guide gene therapy approach utilizing AAV9-mediated expression of CRISPR/Cas13d to suppress levels of C9orf72 sense and antisense repeat-derived transcripts (Kempthorne et al Nature Communications 2025 Jan 8;16(1):459. doi: 10.1038/s41467-024-55550-x).
You will co-lead the assessment of this gene therapy approach using adult administration in C9orf72 BAC transgenic mice; including in vivo administration e.g intrathecal injections and molecular, biochemical and pathological assessment of the treated mice. You will also work closely with a Research Fellow who co-leads the project.
In addition, you will perform ELISAs and immunoassays for C9orf72 dipeptide repeat proteins across a wide range of samples and provide lab management to support the work of the laboratory.
The post is available from 01 October 2025 and funded by LifeArc and UK DRI until 31 March 2028 in the first instance.
You will have or be about to obtain a PhD in a relevant discipline (eg biomedical work) or comparable experience. Experience with in vivo work, with immunostaining, microscopy and image analysis, with molecular biology techniques such as aPR and with ELISAs / immunoassays is essential. Experience with rodent surgery and gene therapy approaches is desirable as is an interest in neuroscience and neurological diseases or gene therapy.
Additional Information
As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:
- 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
Our commitment to Equality, Diversity and Inclusion
The Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visitour EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Silver award , in recognition of our commitment and demonstrable impact in advancing gender equality.
As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.
We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.
#J-18808-LjbffrSenior Research Technician UCL employer: European Commission
The UK Dementia Research Institute at UCL is an exceptional employer, offering a dynamic work environment that fosters innovation and collaboration in the field of neurodegenerative disease research. With generous benefits such as 41 days of holiday, a defined benefit pension scheme, and a strong commitment to equality, diversity, and inclusion, employees are supported in their professional growth while contributing to meaningful advancements in healthcare. Located in London, a hub for academic excellence, the institute provides unique opportunities to engage with leading researchers and cutting-edge technologies.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Research Technician UCL
✨Tip Number 1
Familiarise yourself with the latest research and developments in gene therapy, particularly related to C9orf72 and neurodegenerative diseases. This will not only help you understand the role better but also allow you to engage in meaningful conversations during interviews.
✨Tip Number 2
Network with professionals in the field of neuroscience and gene therapy. Attend relevant conferences or seminars, and connect with researchers on platforms like LinkedIn. This can provide insights into the work being done at UCL and may even lead to referrals.
✨Tip Number 3
Prepare to discuss your hands-on experience with in vivo work and molecular biology techniques. Be ready to share specific examples of your past projects, especially those involving ELISAs, immunoassays, or rodent surgery, as these are crucial for the role.
✨Tip Number 4
Showcase your passion for advancing research in neurodegenerative diseases. Highlight any relevant volunteer work, internships, or personal projects that demonstrate your commitment to this field, as it aligns with the values of the UK Dementia Research Institute.
We think you need these skills to ace Senior Research Technician UCL
Some tips for your application 🫡
Understand the Role:Read the job description thoroughly to grasp the specific responsibilities and requirements of the Senior Research Technician position. Highlight your relevant experience in your application.
Tailor Your CV:Customise your CV to reflect the skills and experiences that align with the job. Emphasise your PhD, in vivo work, and any relevant techniques like ELISAs or immunoassays.
Craft a Compelling Cover Letter:Write a cover letter that not only outlines your qualifications but also expresses your passion for neuroscience and the specific research being conducted at the UK Dementia Research Institute.
Proofread and Edit:Before submitting your application, carefully proofread all documents for spelling and grammatical errors. A polished application reflects attention to detail and professionalism.
How to prepare for a job interview at European Commission
✨Know Your Research
Familiarise yourself with the latest research and developments in neurodegenerative diseases, particularly those related to frontotemporal dementia and amyotrophic lateral sclerosis. Being able to discuss recent findings or methodologies will show your genuine interest and expertise.
✨Demonstrate Technical Skills
Be prepared to discuss your experience with in vivo work, molecular biology techniques, and any relevant lab management skills. Highlight specific projects where you utilised these skills, especially if they relate to gene therapy or immunoassays.
✨Showcase Teamwork and Collaboration
The role involves working closely with a Research Fellow and other team members. Be ready to share examples of how you've successfully collaborated in past projects, emphasising your ability to contribute to a team environment.
✨Align with Their Values
Understand and express your alignment with the UK Dementia Research Institute's commitment to equality, diversity, and inclusion. Share any experiences that demonstrate your support for these values, as they are important to the organisation.
