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- Tasks: Lead innovative research in macrophage biology to develop transformative therapeutics.
- Company: Join Engitix, a pioneering biotech company in West London.
- Benefits: Competitive salary, private medical insurance, pension, and employee perks.
- Other info: Collaborative environment with opportunities to shape the future of targeted therapeutics.
- Why this job: Make a real impact in drug discovery for fibrosis and oncology.
- Qualifications: PhD or MSc with extensive experience in immuno-oncology or fibrosis research.
The predicted salary is between 36000 - 60000 ÂŁ per year.
Your mission is to unlock extracellular matrix biology to develop transformative therapeutics in fibrosis and oncology. We are seeking an accomplished Senior Scientist of Macrophage Biology to play a leading role in defining novel targets in the macrophage‑stromal interface. The role involves establishing a high‑throughput monocyte and macrophage supply chain for biology and drug screening groups across the Discovery unit, leading the nomination and validation of new targets at the macrophage‑stromal interface, and contributing to therapeutic impact in both oncology and fibrosis disease areas. You will also be a key member of a team establishing macrophage‑based target screening assays combined with our novel extracellular matrix‑based cell models, utilizing cellular, immunological, biochemical, molecular biology and functional genomic approaches to validate drug targets and novel therapeutic agents.
Key Responsibilities
- Establish high‑throughput supply of monocyte‑derived macrophages for multiple groups across the Engitix organization
- Drive novel macrophage drug target nomination and validation
- Optimize co‑culture assay systems based on stromal‑macrophage interface in 2D and 3D platforms for drug screening
- Optimize macrophage target screening‑based systems utilizing functional genomic approaches such as siRNA and CRISPR
- Analyze, interpret, report and present results
Your profile
Key Experience
- Demonstrable expertise in macrophage biology, particularly phagocytosis pathways
- Demonstrable experience in immuno‑oncology and/or fibrosis research
- Expertise in the use of multi‑colour flow cytometry and immunofluorescence techniques on tissue sections
- Hands‑on experience of key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT‑PCR, western blotting, siRNA knockdown
Desirable Experience
- Familiarity with molecular pharmacology and oncology drug development
- Prior laboratory research experience in the biotech/pharma industry
Qualifications and Competencies
- PhD in Biomedical Sciences, Immunology, Biochemistry, Biotechnology, or a related discipline, plus 3 years’ experience in a drug screening environment; or an MSc plus 6 years of practical experience with a focus on immuno‑oncology or fibrosis
- Ability to plan, execute, and critically assess experiments independently
- Excellent time‑management skills and ability to work to set deadlines
- Excellent written and verbal communication skills and the ability to work effectively within a team
- Strong troubleshooting skills, with a methodical approach, high attention to detail, and the ability to maintain accurate records
Why us?
- Be part of a pioneering biotech transforming drug discovery through ECM biology
- Work in a collaborative, fast‑paced environment with opportunities to shape the future of targeted therapeutics
- We offer a competitive package including private medical insurance, pension, bonus, employee perks and more
About Us
Engitix is a growing biotech company based in White City Place, West London. We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform. Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates. Join us today in our mission to create a healthier future for patients with life‑threatening diseases such as fibrosis and cancer.
Senior Scientist, Macrophage-Stromal Biology employer: Engitix Therapeutics
Contact Detail:
Engitix Therapeutics Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist, Macrophage-Stromal Biology
✨Tip Number 1
Network like a pro! Reach out to professionals in the biotech field, especially those working in macrophage biology or related areas. Attend industry events or webinars to make connections and learn about potential job openings.
✨Tip Number 2
Show off your skills! Prepare a portfolio showcasing your research, experiments, and any relevant projects. This will help you stand out during interviews and give you something tangible to discuss with potential employers.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors to refine your responses to common questions in the biotech sector. Focus on articulating your experience in macrophage biology and drug screening techniques.
✨Tip Number 4
Apply through our website! We encourage you to submit your application directly on our site for the best chance of getting noticed. Tailor your application to highlight your expertise in immuno-oncology and fibrosis research.
We think you need these skills to ace Senior Scientist, Macrophage-Stromal Biology
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your experience in macrophage biology and drug screening. We want to see how your skills align with our mission at Engitix, so don’t be shy about showcasing relevant projects or research!
Craft a Compelling Cover Letter: Your cover letter is your chance to tell us why you’re the perfect fit for the Senior Scientist role. Share your passion for immuno-oncology and fibrosis research, and explain how your background can contribute to our innovative work.
Showcase Your Technical Skills: We’re looking for expertise in techniques like flow cytometry and qRT-PCR. Be sure to mention any hands-on experience you have with these methods, as well as any other relevant immunological or molecular biology techniques.
Apply Through Our Website: To make sure your application gets the attention it deserves, apply directly through our website. It’s the best way for us to see your application and get you one step closer to joining our team!
How to prepare for a job interview at Engitix Therapeutics
✨Know Your Macrophage Stuff
Make sure you brush up on your knowledge of macrophage biology, especially phagocytosis pathways. Be ready to discuss your previous research and how it relates to the role at Engitix. They’ll want to see that you can connect your expertise with their mission.
✨Showcase Your Techniques
Prepare to talk about your hands-on experience with key immunological and molecular biology techniques. Highlight your familiarity with multi-colour flow cytometry, qRT-PCR, and any other relevant methods. Bring examples of how you've used these techniques in past projects.
✨Demonstrate Team Spirit
Engitix values collaboration, so be ready to share examples of how you've worked effectively within a team. Discuss how you’ve contributed to group projects and how you handle challenges in a collaborative environment. This will show them you’re a good fit for their culture.
✨Prepare for Problem-Solving Questions
Expect questions that assess your troubleshooting skills and methodical approach. Think of specific instances where you faced challenges in your experiments and how you overcame them. This will demonstrate your critical thinking and attention to detail, which are crucial for this role.