At a Glance
- Tasks: Lead innovative research in macrophage biology and drug target validation.
- Company: Join Engitix, a pioneering biotech transforming drug discovery.
- Benefits: Competitive salary, private medical insurance, pension, and employee perks.
- Other info: Collaborative environment with opportunities to shape future therapeutics.
- Why this job: Make a real impact on therapies for cancer and fibrosis.
- Qualifications: PhD or MSc with relevant experience in immuno-oncology or fibrosis.
The predicted salary is between 48000 - 72000 £ per year.
Your mission Engitix Therapeutics is a pioneering biotech company dedicated to unlocking extracellular matrix biology to develop transformative therapeutics in fibrosis and oncology. We are seeking an accomplished Senior Scientist of Macrophage Biology to play a leading role in defining novel targets in the macrophage‑stromal interface. The role involves establishing a high‑throughput monocyte and macrophage supply chain for biology and drug screening groups across the Discovery unit, leading the nomination and validation of new targets at the macrophage‑stromal interface, and contributing to therapeutic impact in both oncology and fibrosis disease areas. You will also be a key member of a team establishing macrophage‑based target screening assays combined with our novel extracellular matrix‑based cell models, utilizing cellular, immunological, biochemical, molecular biology and functional genomic approaches to validate drug targets and novel therapeutic agents.
Key Responsibilities
- Establish high‑throughput supply of monocyte‑derived macrophages for multiple groups across the Engitix organization
- Drive novel macrophage drug target nomination and validation
- Optimize co‑culture assay systems based on stromal‑macrophage interface in 2D and 3D platforms for drug screening
- Optimize macrophage target screening‑based systems utilizing functional genomic approaches such as siRNA and CRISPR
- Analyze, interpret, report and present results
Your profile
Key Experience
- Demonstrable expertise in macrophage biology, particularly phagocytosis pathways
- Demonstrable experience in immuno‑oncology and/or fibrosis research
- Expertise in the use of multi‑colour flow cytometry and immunofluorescence techniques on tissue sections
- Hands‑on experience of key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT‑PCR, western blotting, siRNA knockdown
Desirable Experience
- Familiarity with molecular pharmacology and oncology drug development
- Prior laboratory research experience in the biotech/pharma industry
Qualifications and Competencies
- PhD in Biomedical Sciences, Immunology, Biochemistry, Biotechnology, or a related discipline, plus 3 years’ experience in a drug screening environment; or an MSc plus 6 years of practical experience with a focus on immuno‑oncology or fibrosis
- Ability to plan, execute, and critically assess experiments independently
- Excellent time‑management skills and ability to work to set deadlines
- Excellent written and verbal communication skills and the ability to work effectively within a team
- Strong troubleshooting skills, with a methodical approach, high attention to detail, and the ability to maintain accurate records
Why us?
- Be part of a pioneering biotech transforming drug discovery through ECM biology
- Work in a collaborative, fast‑paced environment with opportunities to shape the future of targeted therapeutics
- We offer a competitive package including private medical insurance, pension, bonus, employee perks and more
About Us
Engitix is a growing biotech company based in White City Place, West London. We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform. Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates. Join us today in our mission to create a healthier future for patients with life‑threatening diseases such as fibrosis and cancer.
Senior Scientist, Macrophage-Stromal Biology in London employer: Engitix Therapeutics
Engitix Therapeutics is an exceptional employer, offering a dynamic and collaborative work environment in the heart of White City Place, West London. As a pioneering biotech company, we provide our employees with the opportunity to contribute to groundbreaking research in fibrosis and oncology, alongside competitive benefits such as private medical insurance, pension plans, and employee perks. Join us to be part of a transformative journey in drug discovery, where your expertise will directly impact the development of innovative therapeutics.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist, Macrophage-Stromal Biology in London
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotech field, especially those who work at Engitix or similar companies. A friendly chat can sometimes lead to insider info about job openings or even a referral.
✨Tip Number 2
Prepare for interviews by diving deep into macrophage biology and the latest research in fibrosis and oncology. We want you to showcase your expertise and passion, so brush up on relevant techniques and be ready to discuss how you can contribute to our mission.
✨Tip Number 3
Don’t just wait for job postings! Keep an eye on our website and apply directly through it. This shows initiative and gives you a better chance of standing out from the crowd.
✨Tip Number 4
Practice your presentation skills! You’ll need to analyse and report results effectively, so being able to communicate your findings clearly will set you apart. Consider doing mock presentations with friends or colleagues to get feedback.
We think you need these skills to ace Senior Scientist, Macrophage-Stromal Biology in London
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience in macrophage biology and drug screening. We want to see how your skills align with the role, so don’t be shy about showcasing relevant projects or techniques you've mastered!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to tell us why you're passionate about macrophage-stromal biology and how you can contribute to our mission. Keep it engaging and personal – we love to see your personality come through.
Showcase Your Achievements:When detailing your experience, focus on specific achievements rather than just listing duties. Quantify your successes where possible, like mentioning any successful drug targets you’ve worked on or innovative assays you’ve developed. This helps us see the impact you've made!
Apply Through Our Website:We encourage you to apply directly through our website for a smoother process. It’s the best way to ensure your application gets into the right hands and shows us you’re serious about joining our team at Engitix!
How to prepare for a job interview at Engitix Therapeutics
✨Know Your Macrophage Biology
Make sure you brush up on your knowledge of macrophage biology, especially phagocytosis pathways. Be ready to discuss how your expertise can contribute to the drug target nomination and validation process at Engitix.
✨Showcase Your Technical Skills
Prepare to talk about your hands-on experience with key immunological and molecular biology techniques. Highlight your familiarity with multi-colour flow cytometry, qRT-PCR, and CRISPR, as these are crucial for the role.
✨Demonstrate Problem-Solving Abilities
Engitix is looking for someone with strong troubleshooting skills. Think of examples from your past work where you faced challenges in experiments and how you methodically approached and resolved them.
✨Communicate Effectively
Since you'll be working in a collaborative environment, practice articulating your thoughts clearly. Prepare to present your previous research findings succinctly, as effective communication is key to success in this role.
