At a Glance
- Tasks: Lead innovative research in macrophage biology and immune-stromal interactions for drug discovery.
- Company: Pioneering biotech transforming drug discovery through ECM biology.
- Benefits: Competitive salary, private medical insurance, pension, bonus, and employee perks.
- Other info: Join a dynamic team and make a real impact in oncology and fibrosis research.
- Why this job: Shape the future of targeted therapeutics in a collaborative, fast-paced environment.
- Qualifications: PhD in Biomedical sciences or related field with relevant experience in drug screening.
The predicted salary is between 60000 - 80000 £ per year.
Your mission We are seeking an accomplished Senior scientist of macrophage biology to provide scientific leadership in macrophage biology and immune‑stromal interactions, driving target identification, validation and translational strategy across our fibrosis and oncology discovery portfolio. We are looking for an expert in macrophage biology who will use their experience to establish macrophage‑based target screening assays combined with our novel extracellular matrix‑based cell models, utilising cellular, immunological, biochemical, molecular biology and functional genomic approaches. You will also provide scientific mentorship and technical guidance to scientists across discovery programmes, champion innovative approaches and emerging technologies in macrophage and immune‑stromal biology, and represent macrophage biology expertise within cross‑functional project teams.
Key Responsibilities
- Establish a suite of macrophage functionality assays to target discovery and drug discovery flowcharts, including activation, cytokine secretion, phagocytosis and efferocytosis assays.
- Optimise macrophage target screening-based systems utilising annotated lmw libraries and functional genomic approaches such as siRNA and CrispR library-based approaches.
- Lead a small team of immunologists/cell biologists involved in execution of projects across both the internal and external biopartnerships.
- Lead the build novel macrophage drug target nomination packages and present case to the leadership for portfolio entry.
- Analyse, interpret, report and present results.
Your profile
Key Experience
- Demonstrable expertise in macrophage biology, in particular phagocytosis pathways.
- Demonstrable experience in target nomination and validation in a biotech or pharmaceutical based setting.
- Expertise in the use of multi‑colour flow cytometry and IF techniques.
- Hands‑on experience of key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT‑PCR, western blotting, siRNA knockdown.
- Have team and direct people leadership experience.
- Familiarity with molecular pharmacology and oncology drug development would be an advantage.
- Prior working experience in the biotech/pharma industry performing laboratory research would be a further plus.
Qualifications and Competencies
- PhD in Biomedical sciences, Immunology, Biochemistry, Biotechnology or related discipline plus 4 years’ experience in drug screening setting or MSc plus 8 years practical experience with a focus on immuno‑oncology or fibrosis.
- Ability to plan, execute and critically assess experiments independently.
- Excellent time‑management skills and ability to work to set deadlines.
- You will be expected to work well within a team, have strong written and verbal communication skills, as well as IT skills.
- You will troubleshoot effectively, work methodically, stay well organised, pay close attention to detail, and maintain accurate records.
Why us?
- Be part of a pioneering biotech transforming drug discovery through ECM biology.
- Work in a collaborative, fast‑paced environment with opportunities to shape the future of targeted therapeutics.
- We offer a competitive package including private medical insurance, pension, bonus, employee perks and more!
Senior Scientist, Macrophage-stromal biology employer: Engitix Limited
Join a pioneering biotech company at the forefront of drug discovery, where your expertise in macrophage biology will drive innovative research in a collaborative and dynamic environment. We prioritise employee growth with opportunities for mentorship and leadership, alongside a competitive benefits package that includes private medical insurance, pension contributions, and various employee perks, all designed to support your well-being and career development.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist, Macrophage-stromal biology
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
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If you're a recent grad, don’t underestimate the power of your university’s alumni network! Reach out to alumni working in biotechnology to gather tips about job openings at companies like Engitix Limited. You'd be surprised how willing people are to help out a fellow grad!
✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like Engitix Limited!
We think you need these skills to ace Senior Scientist, Macrophage-stromal biology
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Engitix Limited that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Engitix Limited.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Engitix Limited does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Engitix Limited
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Engitix Limited. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into Engitix Limited's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Engitix Limited. This shows your passion for the industry!
