At a Glance
- Tasks: Lead DMPK strategies and drive drug development in oncology-focused projects.
- Company: Leading biotech organisation at the forefront of drug discovery.
- Benefits: Competitive salary, career growth, and opportunities to mentor junior scientists.
- Other info: Collaborative environment with opportunities for external partnerships and leadership.
- Why this job: Make a real impact in drug development and shape the future of oncology treatments.
- Qualifications: PhD in a relevant field with strong DMPK and pharmacology expertise.
The predicted salary is between 60000 - 80000 £ per year.
Job Description Principal Scientist (DMPK) Permanent Cambridge A leading biotech organisation is seeking a Principal Scientist with deep DMPK and quantitative pharmacology expertise to support oncology-focused discovery and early development programmes.
You will define and drive translational DMPK strategies across the pipeline, applying mechanistic modelling and pharmacology insight to guide decision‑making from lead optimisation through to IND.
Working cross‑functionally, you will play a key role in shaping programme direction and ensuring high‑quality progression of assets toward the clinic.
Key
Responsibilities: Define and implement translational DMPK strategies across multiple programmes, from lead optimisation to clinical candidate selection.
Develop and apply PK/PD, PBPK, and other mechanistic models to inform dose, schedule, and exposure‑response relationships.
Integrate in vitro, in vivo, and in silico data to support decision‑making and improve translational confidence.
Partner closely with chemistry, biology, toxicology, and clinical teams to guide programme strategy.
Contribute to human dose prediction and support first‑in‑human study design.
Provide scientific leadership within project teams and across the wider DMPK function.
Oversee external collaborations and CRO activities where required.
Mentor and support development of junior scientists within the team.
Present data and strategic recommendations clearly to internal stakeholders and external collaborators.
Key
Requirements: Ph D (or equivalent experience) in a relevant scientific discipline, with significant industry experience in drug discovery and early development.
Strong expertise in DMPK and quantitative pharmacology, including PK/PD and PBPK modelling.
Experience applying modelling and simulation to support candidate selection and clinical translation.
Familiarity with tools such as Phoenix Win Nonlin, NONMEM, MATLAB, or similar.
Proven ability to work in cross‑functional project teams and influence decision‑making.
Experience supporting programmes from discovery through to IND/early clinical development.
Excellent communication skills and the ability to translate complex data into clear insights.
Prior leadership or mentoring experience is desirable.
Apply now by attaching your CV in Word, or contact Paige Keenan (paige. keenan@srgtalent. com) for further information about this opportunity. #J-18808-Ljbffr
Principal Scientist in Cambridge employer: Energy Jobline ZR
World Wide Technology (WWT) is an exceptional employer that fosters a culture of innovation and collaboration, making it an ideal place for a Programme Director in London. With a strong focus on employee growth, WWT offers opportunities to lead cutting-edge automation projects while working in a hybrid environment that promotes work-life balance. The company values transparent communication and client-first service, ensuring that employees are empowered to drive meaningful outcomes and develop their skills in a supportive atmosphere.
