At a Glance
- Tasks: Lead DMPK strategies and drive drug development in oncology-focused projects.
- Company: Leading biotech organisation at the forefront of drug discovery.
- Benefits: Competitive salary, career growth, and opportunities to mentor junior scientists.
- Other info: Collaborative environment with cross-functional teams and external partnerships.
- Why this job: Make a real impact in oncology while shaping the future of drug development.
- Qualifications: PhD in a relevant field with strong DMPK and pharmacology expertise.
The predicted salary is between 60000 - 80000 £ per year.
Job Description
- Principal Scientist (DMPK)
- Permanent
- Cambridge
A leading biotech organisation is seeking a Principal Scientist with deep DMPK and quantitative pharmacology expertise to support oncology-focused discovery and early development programmes.
You will define and drive translational DMPK strategies across the pipeline, applying mechanistic modelling and pharmacology insight to guide decision‑making from lead optimisation through to IND.
Working cross‑functionally, you will play a key role in shaping programme direction and ensuring high‑quality progression of assets toward the clinic.
Key Responsibilities
- Define and implement translational DMPK strategies across multiple programmes, from lead optimisation to clinical candidate selection.
- Develop and apply PK/PD, PBPK, and other mechanistic models to inform dose, schedule, and exposure‑response relationships.
- Integrate in vitro, in vivo, and in silico data to support decision‑making and improve translational confidence.
- Partner closely with chemistry, biology, toxicology, and clinical teams to guide programme strategy.
- Contribute to human dose prediction and support first‑in‑human study design.
- Provide scientific leadership within project teams and across the wider DMPK function.
- Oversee external collaborations and CRO activities where required.
- Mentor and support development of junior scientists within the team.
- Present data and strategic recommendations clearly to internal stakeholders and external collaborators.
Key Requirements
- Ph D (or equivalent experience) in a relevant scientific discipline, with significant industry experience in drug discovery and early development.
- Strong expertise in DMPK and quantitative pharmacology, including PK/PD and PBPK modelling.
- Experience applying modelling and simulation to support candidate selection and clinical translation.
- Familiarity with tools such as Phoenix Win Nonlin, NONMEM, MATLAB, or similar.
- Proven ability to work in cross‑functional project teams and influence decision‑making.
- Experience supporting programmes from discovery through to IND/early clinical development.
- Excellent communication skills and the ability to translate complex data into clear insights.
- Prior leadership or mentoring experience is desirable.
Apply now by attaching your CV in Word, or contact Paige Keenan (paige. keenan@srgtalent. com) for further information about this opportunity.
#J-18808-Ljbffr
Principal Scientist in Cambridge employer: Energy Jobline ZR
World Wide Technology (WWT) is an exceptional employer that fosters a culture of innovation and collaboration, making it an ideal place for a Programme Director in London. With a strong focus on employee growth, WWT offers opportunities to lead cutting-edge automation projects while working in a hybrid environment that promotes work-life balance. The company values transparent communication and client-first service, ensuring that employees are empowered to drive meaningful outcomes and develop their skills in a supportive atmosphere.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Scientist in Cambridge
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
✨Leverage University Alumni Networks
If you're a recent grad, don’t underestimate the power of your university’s alumni network! Reach out to alumni working in biotechnology to gather tips about job openings at companies like Energy Jobline ZR. You'd be surprised how willing people are to help out a fellow grad!
✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like Energy Jobline ZR!
We think you need these skills to ace Principal Scientist in Cambridge
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Energy Jobline ZR that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Energy Jobline ZR.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Energy Jobline ZR does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Energy Jobline ZR
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Energy Jobline ZR. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into Energy Jobline ZR's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Energy Jobline ZR. This shows your passion for the industry!
