At a Glance
- Tasks: Purify and characterise novel mRNA constructs in a fast-paced lab environment.
- Company: Join ScionxBio, a pioneering company in RNA medicine innovation.
- Benefits: Collaborative culture, diverse team, and opportunities for career growth.
- Other info: Inclusive workplace celebrating diversity and equal opportunities for all.
- Why this job: Make a real impact in RNA therapeutics and work with cutting-edge technology.
- Qualifications: Master’s degree in Analytical Chemistry or related field; hands-on HPLC and LC-MS experience.
About ScionxBio
ScionxBio is engineering the next generation of RNA medicines, combining synthetic chemistry and artificial intelligence to create xRNA - a platform for long-acting therapeutics. By expanding RNA beyond nature's four-letter alphabet, we engineer molecules that sustain protein expression for weeks to months rather than days, with the durability that chronic disease demands. With an initial focus on cardiometabolic disease, we are working to turn transient treatments into durable therapies. A spinout from Eleven Therapeutics, we are an international team operating across Cambridge (UK), Tel Aviv, and Cambridge (MA), with our Cambridge (UK) site serving as our largest research and development hub, and we are proud to foster a culture of collaboration, diversity, and scientific excellence.
The Opportunity
We are looking for an ambitious, detail-oriented Analytical Chemist to join our fast-paced lab in Cambridge. In this role, you won't just run samples; you will directly power our pipeline by purifying and characterising novel mRNA constructs and chemically modified oligonucleotides. Working in a collaborative, interdisciplinary environment, you will support synthetic chemists, molecular biologists, and formulation scientists by delivering high-quality analytical data and executing routine downstream purification workflows. The ideal candidate is an adaptable scientist with a Master’s degree, practical experience with HPLC and LC-MS instruments, and a strong desire to build a career in RNA therapeutics. If you are eager to apply your separation chemistry skills to cutting-edge RNA medicines, we invite you to join our team.
Key Responsibilities
- Routine HPLC Purification: Execute semi-preparative and preparative HPLC methods to purify synthetic oligonucleotides, modified xRNA constructs, and mRNA samples to meet purity standards.
- Analytical Testing & Sample Analysis: Operate and maintain analytical instrumentation (HPLC, LC-MS) to assess the purity, concentration, and structural integrity of various RNA constructs.
- Chemical Characterisation: Prepare samples and perform routine LC-MS analysis to confirm chemical modifications and sequence identity.
- Downstream Processing: Conduct post-synthesis and post-purification handling, including desalting, lyophilization, gel analysis, concentration determination and aliquot preparation.
- Equipment Maintenance & Troubleshooting: Perform routine instrument maintenance, system suitability checks, and basic troubleshooting for HPLC and LC-MS systems to minimise downtime.
- Cross-Functional Support & Documentation: Maintain detailed laboratory notebooks, summarise analytical results clearly, and communicate data effectively to cross-functional teams in chemistry and biology.
Qualifications & Experience:
- Master’s degree (MSc or equivalent) in Analytical Chemistry, Biochemistry, Chemistry, or a closely related discipline.
- Direct hands-on industrial or internship experience operating HPLC systems and LC-MS instruments.
- Basic working knowledge of nucleic acid chemistry, synthetic oligonucleotides, or RNA concepts.
- Familiarity with common chromatographic techniques (e.g. Reversed-Phase, Ion-Pair RP, or Anion Exchange).
- Solid problem-solving skills with the ability to optimise oligonucleotide purification workflows.
- Attention to detail/strong documentation/willingness to learn in a fast paced interdisciplinary research environment.
- Strong communication and collaborative skills, dynamic and ability to thrive as part of a team.
ScionxBio is an equal opportunities employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We particularly welcome applications from people who are underrepresented in the sciences.
Analytical Chemist in Cambridge employer: Eleven Therapeutics
ScionxBio is an exceptional employer, offering a unique opportunity to lead the development of cutting-edge RNA medicines within a collaborative and innovative environment. Located in Cambridge, UK, our largest R&D hub, we foster a culture of scientific excellence and provide ample opportunities for professional growth, allowing you to shape the future of therapeutics alongside a talented international team. With a focus on meaningful work and a commitment to advancing healthcare, ScionxBio stands out as a rewarding place to build your career.
StudySmarter Expert Advice🤫
We think this is how you could land Analytical Chemist in Cambridge
✨Get Involved in the Chemistry Community
Engage with local chemistry societies and attend their events. Whether it's a conference or a seminar, these gatherings can be gold mines for networking and spotting job openings at companies like Eleven Therapeutics. Plus, being face-to-face with industry professionals can leave a lasting impression!
✨Utilise Online Platforms for Chemistry Jobs
Don’t just rely on mainstream job boards. Sites like Chemistry World and Chemjobs are specifically geared for our field. Set up alerts for new openings at places like Eleven Therapeutics to be the first to apply!
✨Showcase Your Research & Projects
Create a professional online portfolio that highlights your chemistry projects or research. This could be a blog or a simple website that showcases your skills and experience. When you apply to Eleven Therapeutics, you want them to see what you can do beyond the CV.
✨Connect With Recruiters Specialised in Chemistry
Reach out to recruitment agencies that focus on the chemistry sector. They often have inside tracks on job openings at companies like Eleven Therapeutics and can provide valuable advice tailored to full-time roles in our industry. Don't be shy to ask for insights!
Some tips for your application 🫡
Show Off Your Lab Skills:When applying for a chemistry position, make sure to highlight any lab experience you've got. Mention specific techniques and instruments you've worked with, as they can set you apart from other candidates. For us, demonstrating your practical skills is as important as your theoretical knowledge!
Tailor Your CV to Chemistry:It's essential to structure your CV in a way that’s appealing for a chemistry role. Highlight relevant projects, research publications, and coursework that demonstrate your expertise. If you’ve completed specific certifications, make sure to list those as well—they can really boost your chances!
Craft a Chemistry-Focused Cover Letter:In your cover letter, share your enthusiasm for the field of chemistry and why you want to work at Eleven Therapeutics. Talk about any research or projects that inspire you, and express your willingness to contribute to the team. We love seeing genuine passion for chemistry in applications!
Include Relevant References:Since chemistry roles can be quite specific, having reference letters from professors or previous employers in the field can be a huge plus. Make sure to include contacts who can vouch for your skills and dedication, as it adds credibility to your application.
How to prepare for a job interview at Eleven Therapeutics
✨Know Your Experiments
Get ready to chat about your hands-on experience in the lab. We should be prepared to discuss specific experiments we've conducted, the results, and any challenges we faced. This shows them we don't just know the theory but can apply it in practice!
✨Master the Technical Speak
Brush up on the relevant terminology and concepts in chemistry. Make sure we can discuss different chemical processes, analytical techniques, and safety protocols fluently, as they might throw some technical questions our way. Being precise and confident can really set us apart!
✨Show Off Your Projects
Make a portfolio showcasing our best lab work and any research projects we've been involved in. It's a great way to demonstrate our skills and passion for chemistry. We should tailor it to highlight the aspects most relevant to Eleven Therapeutics and the Analytical Chemist role.
✨Be Ready for Problem Solving
Expect some scenario-based questions where we might need to solve chemical problems on the spot. They could ask about unexpected results or how to improve a process. Let's practice thinking on our feet and explaining our thought process clearly!
