We are seeking an experienced Senior Scientist in In Vivo Pharmacology & Translational Research to join a fast-paced, high-growth biotechnology company. In this pivotal role, you will design, coordinate, and oversee preclinical in vivo studies through external CRO partners, playing a central role in establishing robust proof of concept across innovative oncology pipelines.
Key Responsibilities
In Vivo Study Design & Execution: Independently design and plan robust preclinical in vivo studies (including efficacy, PK/PD, target engagement, mechanism of action, and tolerability) utilizing appropriate oncology models (CDX, PDX, and others). Ensure full compliance with relevant animal license and ethical standards.
CRO Management & Oversight: Lead the scientific coordination and oversight of outsourced in vivo studies, including CRO selection, protocol development, study execution, troubleshooting, and rigorous quality control to ensure delivery of high-quality data on schedule.
Data Analysis & Strategic Interpretation: Analyze and integrate complex in vivo efficacy, PK/PD, and pharmacodynamic biomarker data to evaluate compound performance, guide candidate optimization, and drive go/no-go decisions for pipeline progression.
Translational Pharmacology: Develop and implement translationally relevant in vivo models, dosing strategies, and pharmacodynamic readouts to establish mechanism of action and proof-of-concept for internal programs.
Cross-Functional Collaboration: Work closely with internal Biology, Chemistry, and Translational teams, as well as external academic and industrial partners, aligning in vivo strategy with broader program goals.
Project & Timeline Delivery: Manage project timelines, study budgets, CRO deliverables, and reporting. Proactively identify scientific or operational risks and implement effective mitigation strategies.
Scientific Communication & IP: Present data and recommendations clearly to internal leadership and key external stakeholders. Contribute to patent applications, regulatory documentation, and peer-reviewed scientific publications as required.
Person Specification & Requirements
Education & Qualifica...
Senior Scientist employer: EC Resourcing Careers
Join a dynamic team in Cambridge as a Personal Assistant, where you will enjoy a supportive work culture that values collaboration and proactive engagement. The company offers excellent employee growth opportunities, including training and development, while providing a flexible working environment that promotes work-life balance. With a focus on teamwork and innovation, this role is perfect for those seeking meaningful employment in a vibrant location.
