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- Tasks: Lead and support clinical studies using advanced statistical methods.
- Company: Cytel is a global leader in biostatistical software and services for pharma and biotech.
- Benefits: Enjoy competitive rewards, flexible work options, and comprehensive wellbeing initiatives.
- Why this job: Join a dynamic team driving innovation in clinical development and making a real impact on patient lives.
- Qualifications: Master's degree in statistics or related field; 8+ years in clinical trials required.
- Other info: Experience with SAS programming and CDISC standards is essential.
The predicted salary is between 43200 - 72000 £ per year.
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Principal Biostatistician, united kingdom
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Client:
Cytel
Location:
Job Category:
Other
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EU work permit required:
Yes
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Job Reference:
46f5540b6f9a
Job Views:
33
Posted:
12.08.2025
Expiry Date:
26.09.2025
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Job Description:
At Cytel, we work hard to create successful careers with significant professional growth for our employees, as a result of which they work hard to make Cytel successful. Cytel is a place where talent, experience and integrity come together to advance the state of clinical development.
A Principal Biostatistician with a passion for clinical development and analysis, adept at utilizing advanced statistical methods, you will support or lead one or more Phase I-IV clinical studies. You are excited and enthusiastic. You motivate your teams to do great work and collaborate easily with your clients. You never settle for what is, but always push clinical development forward to what it could be. You motivate others to do the same.
Sponsor-dedicated:
Working fully embedded within one of our pharmaceutical clients, with the support of Cytel right behind you, you\’ll be at the heart of our client\’s innovation. As a Senior Biostatistician you will be dedicated to one of our global pharmaceutical clients; a company that is driving the next generation of patient treatment, where individuals are empowered to work with autonomy and ownership. This is an exciting time to be a part of this new program.
Position Overview:
Our Senior Biostatisticians perform ad-hoc or exploratory analyses to support submission or Health Authority Questions. Having exposure to regulatory work experience is a bonus, for example, if you understand the regulatory questions and translating them to statistical problems, collaborating effectively, with clinical and regulatory colleagues. Supporting medium complexity clinical trials (starting from Design to Archival experience) and supporting some project-level activities.
As a Principal Biostatistician, your responsibilities will include:
- Providing statistical support to clinical studies
- Participating in the development of study protocols, including participation in study design discussions and sample size calculations
- Reviewing CRFs and data review guidelines; developing statistical analysis plans (SAPs), including analysis dataset and TLG specifications
- Performing statistical analyses and interpreting statistical results
- Preparing clinical study reports, including integrated summaries for submissions
- Utilizing your strong communication skills to present and explain the methodology and consequences of decisions.
To be successful in this position you will have:
- Master’s degree in statistics or a related discipline. Ph.D. strongly desired.
- 8+ years supporting clinical trials in the Pharmaceutical or Biotechnology industry.
- Experience working for a CRO is strongly desired.
- Experience in sample size calculation, protocol concept development, protocol development, SAP, and preparing clinical study reports including integrated summaries for submissions.
- Good SAS programming skills for QCing critical outputs, Efficacy/Safety tables, and working closely with Programmers. Knowledge of R programming is a plus.
- Solid understanding & implementation of CDISC requirements for regulatory submissions.
- Adept in ADaM specifications generation and QC of datasets
- The ability to build strong external & internal relationships and motivate a regional or global team.
- Very effective communicator: able to explain methodology and consequences of decisions in lay terms.
Why Cytel?
Cytel is a Global CRO providing ground-breaking biostatistical software and services to large pharma and emerging Biotech clients globally. With our patients at the centre of all that we do, we help to accelerate the development of drugs and devices that save lives and improve quality of life.
At Cytel, our focus is to provide you with a comprehensive and competitive total reward package. In addition, our world class employee benefits, supportive policies and wellbeing initiatives are tailored to support you and your family at all stages of your career – both now, and into the future.
Our values
- We believe in applying scientific rigor to reveal the full promise inherent in data.
- We nurture intellectual curiosity and encourage everyone to approach new challenges with enthusiasm and the desire for discovery.
- We believe in collaboration and invite a diversity of perspectives, drawing on a variety of talents to create a wealth of possibilities
- We prize innovation and seek intelligent solutions using leading-edge technology.
How you will contribute:
- Performing data manipulation, analysis and reporting of clinical trial data, both safety and efficacy (ISS/ISE), utilizing SAS programming
- Generating and validating SDTM and ADaM datasets/analysis files, and tables, listings, and figures ( TLFs)
- Production and QC / validation programming
- Generating complex ad-hoc reports utilizing raw data
- Applying strong understanding/experience of Efficacy analysis
- Creating and reviewing submission documents and eCRTs
- Communicating with and/or responding to internal cross-functional teams and client for project specifications, status, issues or inquiries
- Performing lead duties when called upon
- Serving as team player, with a willingness to go the extra distance to get results, meet deadlines, etc.
- Being adaptable and flexible when priorities change
To be successful in this position you will have:
- Bachelor’s degree in one of the following fields Statistics, Computer Science, Mathematics, etc.
- At least 8 years of SAS programming working with clinical trial data in the Pharmaceutical & Biotech industry with a bachelor’s degree or equivalent. At least 6 years of related experience with a master’s degree or above.
- Study lead experience, preferably juggling multiple projects simultaneously preferred.
- Strong SAS data manipulation, analysis and reporting skills.
- Solid experience implementing the latest CDISC SDTM / ADaM standards.
- Proficiency in Efficacy analysis.
- Familiarity with drug development life cycle and experience with the manipulation, analysis and reporting of clinical trials’ data.
- Submissions experience utilizing define.xml and other submission documents.
- Experience supporting Rare diseases and Gastro Intestinal studies would be a plus.
- Excellent analytical & troubleshooting skills.
- Ability to provide quality output and deliverables, in adherence with challenging timelines.
- Ability to work effectively and successfully in a globally dispersed team environment with cross-cultural partners.
Why Cytel?
Cytel is a Global CRO providing ground-breaking biostatistical software and services to large pharma and emerging Biotech clients globally. With our patients at the centre of all that we do, we help to accelerate the development of drugs and devices that save lives and improve quality of life.
At Cytel, our focus is to provide you with a comprehensive and competitive total reward package. In addition, our world class employee benefits, supportive policies and wellbeing initiatives are tailored to support you and your family at all stages of your career – both now, and into the future.
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Principal Biostatistician employer: Cytel
Contact Detail:
Cytel Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Biostatistician
✨Tip Number 1
Network with professionals in the biostatistics field, especially those who have experience working at Cytel or similar companies. Attend industry conferences and seminars to meet potential colleagues and learn about the latest trends in clinical development.
✨Tip Number 2
Familiarise yourself with the specific statistical methods and software mentioned in the job description, such as SAS and R. Consider taking online courses or certifications to enhance your skills and demonstrate your commitment to continuous learning.
✨Tip Number 3
Prepare for interviews by practising how to explain complex statistical concepts in layman's terms. This will showcase your communication skills and ability to collaborate effectively with cross-functional teams, which is crucial for this role.
✨Tip Number 4
Research Cytel's recent projects and contributions to the pharmaceutical industry. Being knowledgeable about their work will help you tailor your discussions during interviews and show your genuine interest in joining their team.
We think you need these skills to ace Principal Biostatistician
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in biostatistics and clinical trials. Emphasise your skills in SAS programming, statistical analysis, and any experience with CDISC standards, as these are crucial for the role.
Craft a Compelling Cover Letter: In your cover letter, express your passion for clinical development and how your background aligns with Cytel's mission. Mention specific projects or experiences that demonstrate your ability to lead and motivate teams.
Highlight Relevant Experience: When detailing your work history, focus on your 8+ years of experience in the pharmaceutical or biotechnology industry. Include examples of your involvement in Phase I-IV clinical studies and any regulatory work you've done.
Showcase Communication Skills: Since effective communication is key for this role, provide examples of how you've successfully explained complex statistical concepts to non-experts. This will demonstrate your ability to collaborate with cross-functional teams.
How to prepare for a job interview at Cytel
✨Showcase Your Statistical Expertise
As a Principal Biostatistician, it's crucial to demonstrate your advanced statistical knowledge. Be prepared to discuss specific statistical methods you've used in past clinical studies and how they contributed to successful outcomes.
✨Highlight Your Regulatory Experience
Cytel values experience with regulatory submissions. Make sure to mention any relevant work you've done in this area, particularly how you've translated regulatory questions into statistical problems and collaborated with clinical teams.
✨Communicate Clearly and Effectively
Strong communication skills are essential for this role. Practice explaining complex statistical concepts in layman's terms, as you'll need to present methodologies and results to diverse audiences, including clients and team members.
✨Demonstrate Team Leadership and Collaboration
Cytel looks for candidates who can motivate and lead teams. Share examples of how you've successfully led projects or collaborated with cross-functional teams, emphasising your ability to build strong relationships and drive results.
