At a Glance
- Tasks: Design and build innovative CRISPR-based therapeutic constructs for cancer treatment.
- Company: Exciting early-stage biotech focused on programmable therapeutics for oncology.
- Benefits: Join a dynamic team with significant growth potential and impactful projects.
- Other info: Fast-paced environment with opportunities to influence preclinical development.
- Why this job: Be at the forefront of groundbreaking cancer therapies and make a real difference.
- Qualifications: MS or PhD in relevant field with extensive molecular cloning and CRISPR experience.
The predicted salary is between 50000 - 70000 £ per year.
An exciting opportunity has arisen to join a newly funded, early-stage biotechnology company developing a highly ambitious programmable therapeutics platform for oncology. Having recently secured significant seed funding, the company is now expanding its scientific team as it progresses its platform from validation into preclinical development across multiple cancer indications. Their technology is focused on engineering programmable therapeutic systems that can recognise disease-defining genetic features and selectively act within target cells, creating the potential to address oncology indications that remain difficult to treat through conventional therapeutic approaches.
This is a hands-on, high-throughput role at the core of the company’s platform. You will be responsible for designing, building and iterating on novel CRISPR-based therapeutic constructs, helping to shape the candidates that move into preclinical development.
Why Join?
- Join a recently seed-funded biotech at a pivotal stage of scientific and company growth
- Help build a novel oncology platform based on programmable, target-selective therapeutic biology
- Work directly on the therapeutic constructs that underpin the company’s lead programmes
- Apply cutting-edge molecular cloning, protein engineering and CRISPR/Cas expertise in a fast-moving environment
- Play a key role in expanding the platform across multiple oncology indications
About the Role
As Molecular Cloning & Protein Engineering Scientist, you will be responsible for engineering and building the therapeutic constructs at the core of the platform. This is a highly hands-on role suited to a scientist who enjoys rapid construct design, molecular cloning, protein engineering and iterative experimental cycles. You will design and build novel Cas-based therapeutic payloads, engineer constructs for improved specificity and controlled activity, and help expand the programmability of the platform to additional oncogenic targets. Your work will directly influence the therapeutic candidates that enter preclinical development and will sit at the interface of molecular biology, protein engineering, CRISPR technology and oncology.
Key responsibilities
- Designing and constructing engineered Cas-based therapeutic payloads, including conditional protein architectures
- Engineering constructs for enhanced target specificity and controlled activity through directed evolution
- Expanding the programmability of the platform to additional oncogenic targets and demonstrating modular scalability
- Designing and cloning guide RNA libraries for specificity profiling assays, including ONE-seq and CHANGE-seq
- Building and iterating mammalian and bacterial expression vectors to support platform and candidate development
- Supporting stable cell line generation and reporter assay development for construct validation
- Executing rapid-turnaround construct builds in a high-throughput, fast-moving research environment
- Working closely with biology and translational teams to connect construct design with downstream functional performance
About the Candidate
Essential
- MS or PhD in Molecular Biology, Genetics, Bioengineering or a related discipline
- 5+ years of hands-on molecular cloning experience, including Gibson Assembly, Golden Gate and/or Gateway cloning
- Deep expertise in CRISPR/Cas construct design and engineering
- Experience with directed evolution approaches for construct optimisation
- Proficiency in mammalian and bacterial expression vector design
- Experience with stable cell line generation
- Demonstrated ability to execute rapid-turnaround, iterative construct builds
- Experience with reporter assay systems, including fluorescent and/or luminescent assays
Desirable
- Experience with conditional protein systems, such as inducible domains
- Familiarity with base editing or prime editing construct design
- NGS library preparation experience for guide RNA screening platforms
- Background in structural biology or protein biochemistry
This is an excellent opportunity for a molecular cloning and protein engineering scientist to join a recently funded oncology biotech at an early and highly influential stage, working on a novel therapeutic platform with the potential to reshape how genetically defined cancers are targeted.
Molecular Cloning & Protein Engineering Scientist in Slough employer: CT19
Join a pioneering biotechnology company at the forefront of oncology innovation, where your expertise in molecular cloning and protein engineering will directly contribute to groundbreaking therapeutic developments. With a dynamic work culture that fosters collaboration and creativity, you'll have the opportunity to grow alongside a passionate team dedicated to transforming cancer treatment through cutting-edge technology. Enjoy the benefits of working in a fast-paced environment that values scientific excellence and offers significant potential for personal and professional development.
StudySmarter Expert Advice🤫
We think this is how you could land Molecular Cloning & Protein Engineering Scientist in Slough
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
✨Leverage University Alumni Networks
If you're a recent grad, don’t underestimate the power of your university’s alumni network! Reach out to alumni working in biotechnology to gather tips about job openings at companies like CT19. You'd be surprised how willing people are to help out a fellow grad!
✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like CT19!
We think you need these skills to ace Molecular Cloning & Protein Engineering Scientist in Slough
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show CT19 that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at CT19.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that CT19 does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at CT19
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at CT19. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into CT19's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at CT19. This shows your passion for the industry!
