Research Biologist in City of London

An exciting opportunity has arisen to join a newly funded, early-stage biotechnology company developing a highly ambitious programmable therapeutics platform for oncology. Having recently secured significant seed funding, the company is expanding its biology team as it progresses from platform validation into preclinical development across multiple cancer indications. Their technology is focused on engineering programmable therapeutic systems that can distinguish cancer cells from normal tissue based on disease-defining biology, with the aim of creating a more selective approach to oncology treatment.

This is a hands-on cell biology role at the centre of the company’s discovery and preclinical engine. You will generate the in vitro data that determines whether therapeutic constructs selectively activate in cancer cells while sparing normal tissue, directly informing which candidates progress toward animal studies and further development.

• Join a recently seed-funded biotech at a pivotal stage of scientific growth
• Work on a novel oncology platform designed around programmable, target-selective therapeutic biology
• Generate the key in vitro data that drives construct selection and programme advancement
• Work across multiple oncology programmes using diverse cancer and normal cell line panels
• Play a central role in shaping which candidates move into in vivo studies and preclinical development

As Cell Biology Scientist, you will execute the in vitro assays that determine whether therapeutic constructs selectively activate in cancer cells while sparing normal tissue. Working across multiple oncology programmes, you will maintain a diverse panel of cancer and normal cell lines, run high-throughput discrimination assays, and generate quantitative data to support construct selection and programme progression. This is a highly hands-on role suited to a scientist who is comfortable managing parallel experiments, working with mammalian cell culture systems and producing rigorous, well-documented assay data.

Your work will sit at the interface of cell biology, CRISPR-based therapeutic development, oncology and preclinical translation.

• Generating dose-response, multiplexing and specificity data in support of preclinical data packages
• Performing flow cytometry, including multi-colour analysis and sorting
• Running parallel experiments across multiple programmes with strong organisation, documentation and data integrity
• Working closely with molecular biology and translational teams to connect construct design with functional cell-based performance

BS, MS or PhD in Cell Biology, Molecular Biology, Biochemistry or a related discipline

• Proficiency in flow cytometry, including multi-colour analysis and cell sorting
• Rigorous approach to experimental documentation, assay execution and data quality
• Experience with CRISPR editing readout methods, including T7E1, ICE and/or amplicon NGS
• Prior experience working in a fast-moving biotech or platform biology environment

This is an excellent opportunity for a hands-on cell biology scientist to join a recently funded oncology biotech at an early and highly influential stage, generating the data that will directly shape which therapeutic candidates advance toward preclinical development.