Duration: 3-year fixed term
About the role:
Professor Claus Jørgensen Group Leader of the Systems Oncology Group, is looking for a Postdoctoral Scientist to join his group. This is a great opportunity for a self-motivated, meticulous and organised candidate with an interest in protein biochemistry, cell signalling and proteomics analysis to undertake a cutting‑edge research question and work across an international collaboration.
The goal of the Systems Oncology Group is to understand how the tumour microenvironment, and the desmoplastic reaction in particular, regulate tumour cell signalling and therapeutic response in pancreatic ductal adenocarcinoma. The objective of this post is to learn, optimise and apply novel cutting‑edge sample processing methodologies for cell specific phosphoproteomics analysis of metastatic pancreatic cancer. Specifically, you will work across the White lab (MIT, MA, USA) and Jorgensen lab (CRUK MI, UK) to learn the methodology (White lab) and apply it to PDAC 3D and in vivo samples (Jorgensen lab). The post holder is expected to interact collaboratively with members of the laboratories and contribute to the design and development of on‑going research projects in support of the Systems Oncology group.
About you:
You should have a PhD in biochemistry, cancer biology or a related field. Prior experience in protein biochemistry and analysis of cell signalling is essential and prior experience with (phospho)proteomics and in vivo models of cancer is beneficial. Key qualities include independent thinking, ability to work in a team and good communication skills, all of which are needed to efficiently work in a multidisciplinary team. Given the collaborative nature of the project, you are expected to spend time in both laboratories.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world‑leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world.
We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
Informal enquiries can be directed to Professor Claus Jørgensen via email: claus.jorgensen@ cruk.manchester.ac.uk.
Closing date: 30 October 2026
Please note this vacancy will close for applications at 18:00 hours on the closing date specified.
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Postdoctoral Scientist Systems Oncology Group employer: CRUK Manchester Institute
The CRUK Manchester Institute is an exceptional employer, offering a dynamic work environment that fosters innovation and collaboration in cancer research. With access to cutting-edge resources and the opportunity to work alongside leading scientists at both the Institute and the Francis Crick Institute, employees benefit from a culture of continuous learning and professional development. The location in Manchester provides a vibrant city life, enhancing the overall experience for those passionate about making a meaningful impact in the field of genomics and cancer evolution.
