Crick Institute invites applications for a 2027 PhD project focused on the zinc finger antiviral protein (ZAP) and its cofactors KHNYN and Trim25. The project will explore how ZAP restricts a range of viruses, including retroviruses and SARS-CoV-2, using structural, biochemical and enzymological approaches.
The student will purify ZAP, KHNYN and Trim25 domains and full-length proteins, analyse RNA-binding and degradation, and determine cryo-EM structures of ZAP-KHNYN complexes to elucidate
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ZAP-KHNYN Antiviral Researcher employer: Crick
The Francis Crick Institute is an exceptional employer, offering a dynamic work environment that fosters collaboration and innovation in world-class research. With a clear career path in laboratory operations, employees benefit from a supportive culture that prioritises professional growth and development, alongside a balanced work schedule that enhances work-life harmony. Located in the heart of London, the institute provides unique opportunities to contribute to groundbreaking scientific advancements while enjoying the vibrant city life.
