Senior Laboratory Research Scientist - Hess Lab

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the Biological Inorganic Chemistry Laboratory: The Biological Inorganic Chemistry Laboratory, led by Dr Jeannine Hess, combines inorganic chemistry, chemical biology and translational medicine to develop innovative metal-based molecules and chemical tools. The lab focuses on pioneering approaches, including targeted protein degradation, to tackle challenging therapeutic targets.

About the role: We are seeking a Senior Laboratory Research Scientist (SLRS) to join a high-impact cancer project. You will design and execute experiments, support lab operations, train colleagues and contribute to publications. This hands-on role is ideal for an experienced scientist who thrives on problem-solving, collaboration and driving cutting-edge translational research.

What you’ll be doing: You will be responsible for:

• Design, synthesise and characterise heterobifunctional molecules for protein degradation.
• Test interactions with targets using biochemical, biophysical and cell-based assays.
• Collaborate with lab members and STPs to deliver mechanistic insights.
• Plan and run experiments independently, analysing and interpreting results.
• Keep up to date with literature and contribute to publications and meetings.

About you (Minimum Criteria): You will have:

• Essential: A PhD in synthetic chemistry (organic, inorganic, or organometallic) or equivalent experience.
• Strong skills in synthesis, purification and structural analysis.
• Eager to learn new techniques and work at the chemistry-biology interface.
• Experience applying chemistry in biological systems.
• Excellent communication and teamwork skills.
• Well organised with clear, accurate experimental records.

Desirable: Experience with biochemical or biophysical assays. Protein expression, purification and biochemistry experience.

About Working at the Crick: Our values: Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we will make reasonable adjustments if you need them - just let us know when you apply.

If you need assistance with applying (i.e., would like to apply by phone or post) please email: ruby.oluwafemi@crick.ac.uk.

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
• Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans.
• Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups’ support, community and inclusive social events.
• Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme and other career development activities.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.