At a Glance
- Tasks: Lead cutting-edge gene editing and stem cell research projects at a world-class institute.
- Company: The Francis Crick Institute, Europe's largest biomedical research hub.
- Benefits: Competitive salary, generous leave, health support, and career development opportunities.
- Other info: Dynamic, inclusive environment with excellent growth potential.
- Why this job: Make a real impact in biomedical research and collaborate with top scientists.
- Qualifications: PhD or MSc with extensive gene editing and stem cell experience.
The predicted salary is between 47080 - 47080 £ per year.
A full-time permanent position on Crick terms and conditions of employment.
About us
The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines.
About the Stem Cells and Organoid Platform (SCOP)
The Stem Cells and Organoids Platform (SCOP) at the Francis Crick Institute is a Science Technology Platform (STP) dedicated to advancing innovative research in human stem cell biology and organoid technologies.
About the role
We are seeking a highly skilled and motivated Senior Laboratory Research Scientist (SLRS) to lead and support advanced gene editing and stem cell research within SCOP. The successful candidate will play a key role in designing and implementing cutting-edge genome engineering strategies, and driving innovation across diverse research and service projects.
What you'll be doing
- Leading and delivering SCOP research and service projects, owning scientific direction and outcomes.
- Designing and implementing advanced gene editing strategies tailored to project needs.
- Working closely with GeMS and STPs to develop robust, innovative genome engineering solutions.
- Establishing shared methods and technologies with group leaders, strengthening institute capability.
- Staying at the forefront of CRISPR technologies through active horizon scanning and engagement.
- Training and mentoring researchers in gene editing and stem cell culture best practice.
- Engineering and maintaining high-quality iPSC and ESC lines, ensuring reproducibility and QC.
- Supporting effective lab operations, including SOPs, biosafety, resources and equipment.
- Communicating clearly across teams, contributing to reports, collaboration and supportive research culture.
- Participating in a weekend rota for stem cell maintenance.
About you
You will have:
Essential:- Higher degree in a relevant field (PhD, MSc) with three years of research experience.
- Extensive proficiency in designing and implementing gene editing strategies in human pluripotent stem cells.
- Extensive proficiency in molecular biology techniques.
- Strong background in stem cell biology, with hands-on experience in the culture and maintenance of human pluripotent stem cells.
- Experience using bioinformatics tools for guide RNA design, off-target prediction, and genomic data analysis.
- Experience in experimental design, troubleshooting, and data analysis.
- Excellent attention to detail and commitment to maintaining high standards of data quality, documentation, and reproducibility.
- Proven ability to manage multiple projects simultaneously and deliver results within agreed timelines.
- Strong communication and interpersonal skills.
- Demonstrated understanding of biosafety and ethical considerations related to the genetic modification of human cells.
- Experience with genome editing of organoids.
- Understanding of genetic modification workflows.
- Familiarity with reprogramming techniques for the derivation of iPSCs.
- Familiarity with organoids, assembloids and/or spheroids.
- Familiarity with liquid handlers/automation tools.
About Working at the Crick
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed.
What will you receive?
- Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
- Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
- Health & Well-being: 24/7 GP consultation services.
- Work-Life Balance: Back-up care for dependents.
- Career support: Since September 2017 Crick has been a signatory to the Technician Commitment.
Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed.
Senior Laboratory Research Scientist – Gene Editing employer: Crick Group
The Crick Institute offers an exceptional environment for Postdoctoral Fellows, combining cutting-edge research with a collaborative and supportive culture in the heart of London. With access to state-of-the-art facilities, generous funding for research, and active mentorship from experienced leaders like James DiFrisco, employees are empowered to develop their skills and contribute to groundbreaking projects in theoretical biology. The institute prioritises professional growth, providing numerous training opportunities and fostering a dynamic atmosphere that encourages innovation and teamwork.
