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- Tasks: Join our team to investigate ALS using cutting-edge stem cell models and CRISPR technology.
- Company: Be part of King's College London's Basic & Clinical Neuroscience Department, renowned for its research excellence.
- Benefits: Enjoy a competitive salary, potential PhD opportunities, and a supportive, inclusive work environment.
- Why this job: Make a real impact in neurobiology while collaborating with top researchers and accessing state-of-the-art facilities.
- Qualifications: BSc or MSc in relevant fields; lab experience and a passion for research are essential.
- Other info: We value diversity and encourage applicants from all backgrounds; sponsorship available for eligible candidates.
The predicted salary is between 32402 - 36718 £ per year.
The Department of Basic & Clinical Neuroscience at King's is looking for a research assistant to join the ALS/FTD research group led by PI Jemeen Sreedharan. Our group works to investigate the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) using in vitro and in vivo (mouse and fly) models. We develop stem cell-based models for these neurodegenerative disorders by producing high-purity cultures of human neural cells as well as co-cultures of neurones and glial cells. Our work involves the use of advanced genetic editing technologies to create these models with important isogenic controls.
We are seeking an enthusiastic research assistant to take part in research investigating the molecular causes of ALS using human iPSC-derived motor neurones. You will use CRISPR-Cas9 editing to generate new cell lines harbouring ALS-causing mutations on an isogenic background. You will differentiate, maintain and phenotype neuronal cultures derived from these iPSCs and use qRT-PCR, western blotting, confocal microscopy and other approaches to understand the effects of mutations in proteins such as TDP-43. You will contribute to the overall activities of the research as required and assist in the day-to-day running of the lab. You will keep records of the experiments and results, and prepare progress reports on research for lab meetings, departmental seminars and for funding bodies as required.
To be successful in this role, we are looking for candidates to have the following skills and experience:
- BSc or MSc in molecular and cell biology, neuroscience, or a relevant subject area.
- Proven research aptitude and laboratory experience.
- Ability to work independently and collaboratively.
- Ability to manage time and work to deadlines.
- Ability to critically evaluate publications, experimental design, protocols, and research findings.
- Excellent interpersonal, oral and written communication skills.
- Ability to present data in lab meetings and departmental meetings.
- Knowledge and understanding of the principles of resource and budgetary management, sustainability, and inclusivity.
- Experience in wet lab techniques, such as western blotting, RT-qPCR, molecular cloning, etc.
- Experience in cell culture, in particular iPSC culture.
- Experience in statistical analysis and use of biocomputational tools.
- Experience in microscopy, preferentially confocal imaging.
We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community. We are committed to working with our staff and unions, to continue to support our people and to develop a diverse and inclusive culture at King's.
Research Assistant in Stem Cell Neurobiology employer: Corehr
Contact Detail:
Corehr Recruiting Team
jemeen.sreedharan@kcl.ac.uk
StudySmarter Expert Advice 🤫
We think this is how you could land Research Assistant in Stem Cell Neurobiology
✨Tip Number 1
Familiarise yourself with the latest research in ALS and FTD. Being knowledgeable about current studies and breakthroughs will not only help you during interviews but also demonstrate your genuine interest in the field.
✨Tip Number 2
Network with professionals in the neuroscience community, especially those involved in ALS research. Attend relevant seminars or workshops, and don’t hesitate to reach out to researchers on platforms like LinkedIn to express your interest in their work.
✨Tip Number 3
Prepare to discuss your hands-on experience with wet lab techniques, particularly those mentioned in the job description. Be ready to share specific examples of how you've applied these skills in previous roles or projects.
✨Tip Number 4
Showcase your ability to work both independently and collaboratively. Think of examples from your past experiences where you successfully managed tasks on your own and contributed to team projects, as this is crucial for the role.
We think you need these skills to ace Research Assistant in Stem Cell Neurobiology
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in molecular and cell biology, neuroscience, and any laboratory techniques mentioned in the job description. Use specific examples to demonstrate your skills in wet lab techniques, such as western blotting and RT-qPCR.
Craft a Strong Supporting Statement: In your supporting statement, clearly address how you meet the essential criteria listed in the job advert. Provide concrete examples of your research aptitude, ability to work independently and collaboratively, and your experience with iPSC culture and microscopy.
Showcase Your Communication Skills: Since excellent interpersonal and communication skills are crucial for this role, include examples of how you've effectively presented data in lab meetings or departmental seminars. Highlight any experience you have in preparing progress reports for funding bodies.
Highlight Your Problem-Solving Abilities: Demonstrate your 'can-do' attitude by providing examples of challenges you've faced in previous research roles and how you overcame them. This will show that you can manage time effectively and work to deadlines, which is essential for this position.
How to prepare for a job interview at Corehr
✨Know Your Research
Familiarise yourself with the latest research in ALS and FTD, especially the work being done by Dr Sreedharan's group. Be prepared to discuss how your background in molecular and cell biology aligns with their current projects.
✨Demonstrate Technical Skills
Highlight your experience with wet lab techniques such as CRISPR-Cas9 editing, western blotting, and qRT-PCR. Be ready to provide specific examples of how you've successfully used these techniques in past research.
✨Show Your Collaborative Spirit
Emphasise your ability to work both independently and as part of a team. Share examples of how you've collaborated on projects, managed time effectively, and contributed to lab meetings or departmental seminars.
✨Prepare Thoughtful Questions
Prepare insightful questions about the research group's goals, challenges, and future directions. This shows your genuine interest in the role and helps you assess if the position is the right fit for you.
