At a Glance
- Tasks: Support research on protein-RNA condensates and neurodegeneration in a dynamic lab environment.
- Company: Join the Oxford-GSK Institute of Molecular & Computational Medicine, a leader in innovative research.
- Benefits: Competitive salary, pension, and the chance to work with top scientists in a collaborative setting.
- Other info: Exciting opportunity for career growth in a multidisciplinary team focused on scientific creativity.
- Why this job: Make a real impact in understanding neurodegenerative diseases while developing your research skills.
- Qualifications: MSc in relevant field and experience with ALS and TDP-43 protein required.
The predicted salary is between 35681 - 41636 £ per year.
We are seeking to appoint a new Research Assistant in Composition of protein-RNA condensates to join our Oxford-GSK Institute of Molecular and Computational Medicine (IMCM). This post provides an exciting opportunity to join the newly established multidisciplinary Oxford-GSK Institute for Molecular & Computational Medicine (IMCM) operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN), Nuffield Department of Population Health (NDPH) and Department of Physiology, Anatomy and Genetics (DPAG).
The Hallegger Lab is an inclusive environment with a focus on positive and proactive mentorship, teamwork, and scientific creativity. The Hallegger lab addresses the question of what proteomics and transcriptomics changes are linked to the earliest stages in neurodegeneration. In this role, you will support multidisciplinary approaches to discover and validate proteomic changes associated with changes in the condensation behaviour of TDP-43, an RNA-binding protein central to Motor Neuron Disease (MND) and ALS (Amyotrophic lateral sclerosis).
Recent work from Dr. Hallegger's team has demonstrated, by taking an interdisciplinary approach, how RNA- and condensation-dependent assemblies affect transcriptome-wide RNA networks. This work in the increasingly important field of membrane-less organelles/condensates describes how the TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.
With a strong background in biochemistry, cell biology and computational and statistical analysis, you will regularly communicate and work collaboratively with the Oxford-GSK IMCM post-doctoral fellows and researchers in the institute, keeping in mind the Oxford-GSK IMCM's approach and mission.
As a Research Assistant with experience in iPSC work and computational and statistical skills, you will be part of a multi-disciplinary, science driven team delivering proteomics, molecular biology and imaging-based results to better understand the molecular mechanisms in neurodegenerative disease. You will work closely with the bioinformatics and proteomics teams on the data analysis. You will work to tight and moving deadlines, adopting a flexible approach, communicating progress clearly, and prioritising effectively across the team.
This position represents an exciting opportunity to work in a dynamic research environment, driving the delivery of a proteomics project in close collaboration with the joint Oxford-GSK research project teams.
It is essential that you hold an MSc degree in Neuroscience, Biology, Molecular Biology, Biochemistry, Biomedical Sciences, Genetics/Genomics or related area, with experience and knowledge of the neurodegenerative disease ALS and in particular the disease-linked TDP-43 protein. Similarly, you will have excellent experimental skills and the ability to independently drive a project, including decision-making, problem-solving, planning, and organising with strong communication skills both in writing and oral presentations.
This position is offered full time on a fixed term contract for 12 months and is funded by GSK. Salary (£): Research Grade 6: Salary in range £35,681 - £41,636 per annum. This is inclusive of a pensionable Oxford University Weighting of £1,730 per year.
Research Assistant - Composition of protein-RNA condensates in Oxford employer: Corehr
Sheffield Hallam University is an exceptional employer, offering a vibrant and inclusive work culture that fosters innovation and collaboration within the Smart Interactive Technologies Lab. As a Research Fellow, you will have access to cutting-edge research infrastructure and the opportunity to contribute to impactful projects aimed at improving maternal health outcomes, all while benefiting from a supportive environment that prioritises professional growth and development. Join us in making a meaningful difference in healthcare through responsible and human-centred digital innovation.
StudySmarter Expert Advice🤫
We think this is how you could land Research Assistant - Composition of protein-RNA condensates in Oxford
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We think you need these skills to ace Research Assistant - Composition of protein-RNA condensates in Oxford
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Corehr that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Corehr.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Corehr does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
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How to prepare for a job interview at Corehr
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Corehr. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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