At a Glance
- Tasks: Explore neuron-astrocyte communication in neurodegeneration using cutting-edge techniques.
- Company: Join the innovative Oxford-GSK Institute of Molecular and Computational Medicine.
- Benefits: Competitive salary, pension, and a supportive research environment.
- Other info: Collaborative team with excellent mentorship and career growth opportunities.
- Why this job: Make a real impact in neuroscience while developing your independent research career.
- Qualifications: PhD/DPhil in relevant fields and experience with iPSCs and neurodegenerative diseases.
The predicted salary is between 39424 - 43984 £ per year.
We are looking for a highly motivated Postdoctoral Research Scientist in neuron-astrocyte communication in neurodegeneration looking to develop an independent research career to join the Lang group (Oxford-GSK IMCM Fellow & NDM Group Leader, University of Oxford). Dr. Lang leads a team of scientists dedicated to answering pressing questions in the field of molecular neurodegeneration. The Lang Lab is an inclusive environment with a focus on positive and proactive mentorship, teamwork, and scientific creativity.
This post provides an exciting opportunity to join the multidisciplinary Oxford-GSK Institute for Molecular & Computational Medicine (IMCM) operating within Nuffield Department of Medicine (NDM) in collaboration with Nuffield Department of Clinical Neuroscience (NDCN), Sir William Dunn School of Pathology and Department of Physiology, Anatomy and Genetics (DPAG). The aim of the institute is to improve tools in, and knowledge from, genetics, genomics, molecular and single cell biology, spatial imaging, machine learning and novel methods of data handling to study the pattern of diseases in new ways.
You will be responsible for undertaking a multidisciplinary approach to understand mechanisms of communication between dopamine neurons and astrocytes in health and neurodegenerative disease. You will perform neuronal and astrocyte differentiation of iPSCs from Parkinson’s patients and controls. You will perform monocultures and microfluidic co-culture of iPSC-derived dopamine neurons and astrocytes from Parkinson’s patients and controls. You will utilise transcriptomic approaches to look at gene expression changes to identify proteins/pathways involved in iPSC-derived neuron-astrocyte support or damage. You will perform extracellular vesicle isolation in biofluids & lentiviral CRISPR-Cas9 knockdown of genes of interest in iPSC-derived dopamine neurons and astrocytes. You will manage your own academic research and administrative activities, including small scale project management and co-ordination of multiple aspects of work to meet deadlines.
It is essential that you hold a PhD/DPhil (or close to completion) in Neuroscience, Biology, Molecular Biology, Biochemistry, Biomedical Sciences, Genetics/Genomics or related area. You must have hands-on experience in the differentiation of human induced pluripotent stem cells (iPSCs) into neurons. You must have experience and knowledge of neurodegenerative diseases, such as Parkinson’s.
Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.
This position is offered full time on a fixed term contract for 36 months and is funded by Oxford-GSK IMCM. Only applications received before 12 midday on Monday, 11 August 2026 will be considered.
Salary (£) : Research Grade 7: £39,424 - £43,984 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,730 per year.
Postdoctoral Research Scientist in neuron-astrocyte communication in neurodegeneration in Oxford employer: Corehr
Sheffield Hallam University is an exceptional employer, offering a vibrant and inclusive work culture that fosters innovation and collaboration within the Smart Interactive Technologies Lab. As a Research Fellow, you will have access to cutting-edge research infrastructure and the opportunity to contribute to impactful projects aimed at improving maternal health outcomes, all while benefiting from a supportive environment that prioritises professional growth and development. Join us in making a meaningful difference in healthcare through responsible and human-centred digital innovation.
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Research Scientist in neuron-astrocyte communication in neurodegeneration in Oxford
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We think you need these skills to ace Postdoctoral Research Scientist in neuron-astrocyte communication in neurodegeneration in Oxford
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Corehr that you have the hands-on skills they need.
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Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Corehr does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
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How to prepare for a job interview at Corehr
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Corehr. You might even be asked to demonstrate your understanding of these processes.
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Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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