(Senior or Non Senior) Computational Genomics Scientist - Pathogen in Oxford

At the Ellison Institute of Technology (EIT), we are on a mission to translate scientific discovery into real world impact. We bring together visionary scientists, technologists, engineers, researchers, educators and innovators to tackle humanity's greatest challenges in four transformative areas:

• Health, Medical Science & Generative Biology
• Food Security & Sustainable Agriculture
• Climate Change & Managing CO2
• Artificial Intelligence & Robotics

This is ambitious work that demands curiosity, courage, and a relentless drive to make a difference. At EIT, you'll join a community built on excellence, innovation, tenacity, trust, and collaboration, where bold ideas become real-world breakthroughs.

Welcome To The Pathogen Project: Within this ecosystem, the Pathogen Project exemplifies EIT's dedication to ground-breaking science. It seeks to transform pathogen risk management, detection and response by leveraging Whole Genome Sequencing (WGS)-based metagenomic and pathogen-specific analytical tools. The goal is to power metagenomic devices using long-read sequencing technologies by building a comprehensive database of pathogen information to inform response.

Your Role: At EIT we are seeking an experienced and detail-oriented Scientist with recognised expertise in developing computational methods and algorithms for genomic sequencing data analysis. This is an exciting opportunity to develop novel computational approaches for microbial data that will become part of our diagnostic products and thus help shape the future of infectious disease diagnostics. Reporting to the Lead Scientist in Computational Genomics, you will work closely with computational scientists, bioinformaticians, software engineers, and our database and data platform teams to deliver scientifically rigorous, scalable, and clinically relevant innovation in the microbial genomics space.

Key Responsibilities:

• Design, develop and evaluate novel computational approaches in areas such as genome assembly, binning, and functional characterisation of genomes from metagenomic sequencing data.
• Collaborate with scientists across EIT to apply the latest developments in AI/ML to real-world challenges in the pathogen space.
• Work with bioinformaticians and software engineers to implement methods in scalable, reproducible, and modular workflows.
• Perform rigorous benchmarking using public and internal datasets, and guide experimental validation efforts in collaboration with our wet-lab teams.
• Communicate technical concepts to broad audiences and collaborate with interdisciplinary colleagues across the organisation.

Essential Knowledge, Skills and Experience:

• PhD or equivalent experience in bioinformatics, computational biology, computer science, or a related quantitative field.
• Senior: At least 3 years of postdoctoral or industry experience developing computational methods for next-generation sequencing data; Non-Senior: Hands-on experience developing computational methods for next-generation sequencing data.
• Significant experience with bioinformatics methods such as efficient search and storage of DNA sequences, genome assembly, genome annotation, pangenomes, phylogenetics, and comparative genomics.
• Solid understanding of data structures, algorithms, and statistical methods (e.g. De Bruijn graphs, hashing, Burrows-Wheeler transform, Bayesian methods, mixed models, dimensionality reduction, embeddings).
• Experience with machine learning in the context of biological data, particularly sequencing data.
• Proficient in the use of command-line interfaces, low and high-level programming languages (e.g. Python, C, C++, Rust) and modern software development techniques (version control, CI/CD).
• Track record of scientific output and engagement with the computational genomics community.

Desirable Knowledge, Skills And Experience:

• Experience working with microbial genomes and shotgun metagenomics data.
• Experience working with long-read sequencing data (ONT).
• Experience with bioinformatics workflow management (e.g. Nextflow) and cloud computing (e.g. OCI, AWS, GCP).
• Contributions to open-source bioinformatics software.
• Previous experience mentoring or line-managing scientists (for Senior).

Key Attributes:

• Strategic thinker with the ability to translate scientific insights into practical solutions.
• Effective communicator and enthusiastic knowledge sharer across disciplines.
• Rigorous and detail-oriented with a commitment to reproducibility and benchmarking.
• Comfortable in a fast-paced, interdisciplinary environment and able to adapt to evolving priorities.
• Collaborative ethos with the ability to work across teams and domains.

Benefits:

• Salary: Competitive + travel allowance + bonus.
• Enhanced holiday + options to buy additional days.
• Pension.
• Life Assurance.
• Income Protection.
• Private Medical Insurance.
• Hospital Cash Plan.
• Therapy Services.
• Perk Box.
• Electric Car Scheme.
• Childcare benefit.

You must have the permanent right to work in the UK and be willing to travel when required. Given the specialised nature of this role, we can consider sponsorship for candidates who meet the expectations outlined in the job description. You will live in, or within easy commuting distance of, Oxford (or be willing to relocate).