Scientist (High Throughput Screening, Antibody Discovery)

Under the leadership of Nick Tribble, we currently have an exciting opportunity within our Drug Discovery team for an experienced Scientist to expand and enhance our capabilities in therapeutic antibody discovery.

As the world's biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.

In this lab-based role you will use your knowledge and experience with biochemical and cell-based high throughput screening technology to develop and execute high throughput screening assays, and associated drug discovery activities within the Antibody Discovery team.

You’ll bring with you experience of developing and running cell-based assays to identify early-stage drug candidates - ideally antibodies, but experience of small molecules will be considered.

What will I be doing?

• Working on the development and execution of high throughput screening assays to enable the identification and characterisation of therapeutic antibodies.
• Contributing to project progression as part of a multi-disciplinary team.
• Utilising biochemical and cell-based assays to characterise functional properties of therapeutic antibodies (e.g. IC50 or EC50 determination).
• Working with a variety of assay formats, detection technologies and laboratory automation to maximise efficiency.
• Maintaining relevant technical and intellectual expertise relevant to the field (e.g. assays development and antibody discovery).
• Recording, tracking and presenting data for project team meetings.

What skills will I need?

• PhD in relevant field or Degree with equivalent drug discovery experience.
• Strong knowledge of biochemical and cell-based high throughput screening (HTS) technologies utilized in pre-clinical antibody drug discovery.
• Experience of developing and running high throughput cell-based assays to identify early-stage drug candidates - ideally antibodies, but experience of small molecules will be considered.
• Extensive experience of working with a variety of assay formats and detection technologies such as flow cytometry, high content imaging, ELISA, MSD and HTRF assays.
• Experience of applying a range of laboratory automation solutions (e.g. Viaflo, Hamilton, HighRes) to support drug discovery cascades is highly desirable.
• Proactive, with a 'can do' attitude; with a demonstrated ability to prioritise own work effectively, multi-task and adapt flexibly to changing priorities.
• Strength in collaborative working and proven ability to interact and effectively communicate scientific objectives and project results with colleagues.
• Demonstrated interest in scientific innovation and driving new capability development to support antibody discovery.

Our organisation values are designed to guide all that we do:

• Bold: Act with ambition, courage and determination
• Credible: Act with rigour and professionalism
• Human: Act to have a positive impact on people
• Together: Act inclusively and collaboratively

If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience we’d still love to hear from you.

We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools.

How do I apply?

We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview.