Principal Scientist (Biochemistry/Enzymology)

Principal Scientist (Biochemistry/Enzymology)

Apply locations: CRT Cambridge (Babraham), Cancer Research UK Scotland Institute

Time type: Full time | Posted on: Posted Yesterday | Deadline: May 29, 2025 (26 days left)

Join over 4,000 professionals dedicated to a single purpose: beating cancer.

Position Details

Principal Scientist – Biochemistry/Enzymology (Under the leadership of Agnes Martin )

Salary: From £50,400 to £57,400 per annum, depending on experience, plus benefits including up to 12% pension contribution and income protection.

Reports to: Group Leader, Mechanistic Pharmacology

Department: Research and Innovation

Contract: Permanent

Hours: Full time, 35 hours/week (flexible working considered)

Locations: Babraham Research Campus, Cambridge, or Scotland Institute, Glasgow

Application deadline: Early applications are encouraged as the vacancy may close sooner due to high volume or if a suitable candidate is found. For inquiries or adjustments, contact or 020 3469 8400.

Visa sponsorship: Available; please indicate on your application if applicable.

About Us

Cancer Research UK is committed to beating cancer through innovative research. We are expanding our Drug Discovery team and seek a passionate Principal Scientist to lead biochemical assay design, development, and analysis, based at our Cambridge facilities. This role is pivotal as we implement our 5-year strategic plan.

About CRUK Drug Discovery

As the world’s largest cancer research charity, we\’ve helped bring eleven new cancer drugs to market. Our new initiative, Cancer Research Horizons, unites our drug discovery efforts to accelerate the development of new treatments by leveraging our expertise, academic partnerships, and cutting-edge technology.

Key Responsibilities

• Design and develop physiologically relevant biochemical assays for cancer targets.
• Enable high-throughput screening and profile structure-activity relationships of small molecules.
• Characterize mechanisms of action to inform dose prediction and clinical efficacy.
• Stay abreast of advanced cellular pharmacology techniques and promote innovative approaches.
• Engage in scientific dissemination through conferences, posters, talks, and publications.

Required Skills and Experience

• PhD in biochemistry or pharmacology, or relevant experience.
• Experience in drug discovery, enzyme mechanisms, and small molecule inhibitors.
• Expertise in enzymology, biochemical assays, and detection technologies.
• Proven leadership and strategic direction skills.
• Strong external reputation through publications and conference presentations.

Our Values

We act with ambition, professionalism, positivity, and collaboration to achieve our mission to beat cancer. We welcome applications from diverse backgrounds and are committed to inclusive hiring practices.

What You Will Gain

We offer a supportive work environment, comprehensive benefits, career development opportunities, and tools to promote work-life balance. Explore our benefits on our careers webpage.

Application Process

We use anonymized shortlisting to promote fairness. Submit your CV and complete the online work history section. Follow us on LinkedIn, Facebook, Instagram, X, and YouTube for updates.

We encourage candidates from all backgrounds, especially underrepresented groups, to apply. For adjustments or inquiries, contact or call 020 3469 8400. Applicants must be over 18 for safety reasons.

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