Senior Principal Scientist (Therapeutic Translation)
£58,400 - £76,000 plus benefits
Department: Therapeutic Innovation - R&I
Reports to: Chief Scientific Officer
Location: Babraham Research Campus, Cambridge with high flex (1 to 2 days per week on site).
Contract type/hours: Permanent, Full-time 35 hours per week (flexible working requests will be considered).
Closing date: Sunday 18th October 23:55pm
Interview Date: To be confirmed.
Interview process: Competency-based interview process with task/presentation.
At Cancer Research UK, we exist to beat cancer.
At Cancer Research Horizons (CRH) our Therapeutic Innovation team is investing in a world‑leading capability to translate breakthrough discovery science into the next generation of oncology therapeutics. As part of this evolution, we have established a new Therapeutic Translation team. A group of experienced oncology drug discoverers dedicated to identifying, shaping, and accelerating the most exciting science emerging from the CRUK research ecosystem. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters - impacting patients, families, and the future of science.
As a Senior Principal Scientist, you will play a pivotal role in evaluating the breadth of CRUK’s research portfolio, as well as emerging scientific areas with strong therapeutic potential. Working across CRUK Institutes, Centres, and international academic collaborations, you will build trusted relationships with scientific leaders to uncover early‑stage ideas with the potential to become validated, fundable therapeutic concepts.
This is an outward‑facing, high‑visibility role that requires deep scientific insight, strategic judgement, and a natural curiosity for uncovering translational opportunity before it becomes obvious. You will help transform breakthrough biology into new medicines for cancer patients, shaping not only individual projects, but the future direction of CRUK‑funded oncology research itself.
This position offers a rare opportunity for an accomplished drug hunter to influence therapeutic innovation on a national scale and support the discovery of tomorrow’s cancer therapies. You’ll be joining over 200 staff across CRH from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer.
What will you be doing?
- Support the implementation of a new Therapeutic Translation strategy for CRH TI to enhance the number of therapeutic opportunitiesidentifiedfrom CRUK funded research.
- Maintain awareness of emerging areas ofcancerbiology and technological advances relevant to theobjectivesof CRH TIin order toidentifyand recommend priority translational opportunities for examination or investment.
- Analyse current and future CRUK funded research to highlight key translational opportunities.
- Work with CRUK PIs, Research Institutes and Centres, within the UK and internationally (CRUK/NCI Grand Challenges or Academic Alliances) toidentifytranslational opportunities.
- Perform detailed reviews of opportunitiesidentified.
- Shape new hypotheses and collaborative proposals in partnership with PIs.
- Signpost the Therapeutic Catalyst scheme and assist the development and submission of EOI proposals.
- Propose translational opportunities for strategic interventional funding.
- Propose opportunities for consideration as TI collaborations and for experimental validation by TI’s Portfolio Generation.
- Promote the visibility of the Therapeutic Translation team in the academic research community and life science sector.
What are we looking for?
- PhD or equivalent in a relevant discipline(e.g.Bioscience, Chemical Biology)with previousexperience of working ononcologydrug discovery in industry.
- You will haveexpertiseinidentifyingand developingsmall molecule therapies and/or biotherapeutics, with an awareness of alternativetherapeuticmodalities.
- Agoodunderstanding of mechanistic cancer biology, current therapeutic approaches in oncology, andpersonalisedmedicine strategies applied to cancer treatment.
- Agoodunderstanding of translating opportunities from a target concept to a therapeutic, including relevant target validation methods and the use of preclinical models.
- Previousexperience of working productively with or within the academic sector on translational/therapeutic projects.
- Knowledge of the broad drug development pipeline, from Target Identificationthrough toclinical development.
- Excellent interpersonal skills with the ability to network and build strong working relationships.
- Excellent written and verbal communication skills.
- Strong and collaborative teamplayer.
- Self-motivated individualwith excellent time-management skills,able to prioritise workload and deliver to tight deadlines.
Our organisation values are designed to guide all that we do.
Bold: Act with ambition, courage and determination
Credible: Act with rigour and professionalism
Human : Act to have a positive impact on people
Together: Act inclusively and collaboratively
We’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.
What will I gain?
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance and take positive steps in your career.
You can explore our benefits by visiting our careers web page.
Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.
We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact recruitment@cancer.org.uk or 0 20 3469 8400 as soon as possible.
Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.
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Senior Principal Scientist (Thereputic Translation) in Cambridge employer: Cancer Research UK (CRUK)
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