At a Glance
- Tasks: Join a cutting-edge research team exploring the genome's structure and function.
- Company: Cancer Research UK Cambridge Institute, renowned for innovative cancer research.
- Benefits: Four-year funded studentship with a stipend starting at £22,500 per year.
- Other info: Collaborative environment with access to state-of-the-art facilities and training.
- Why this job: Make a real impact in cancer research while developing your skills in genomics.
- Qualifications: Strong motivation, background in molecular biology or biochemistry, and knowledge of genomics.
The predicted salary is between 22500 - 22500 € per year.
PhD Studentship: The Structure and Function of the Genome
Supervisor: Professor Sir Shankar Balasubramanian
Department/Location: Cancer Research UK Cambridge Institute
Deadline for application: 13 November 2025
Course start date: 1 October 2026
Overview
Professor Sir Shankar Balasubramanian is seeking a PhD student to work on the structure and function of the genome. The position is based in the Balasubramanian Lab at the CRUK Cambridge Institute, with collaborative interactions with the Yusuf Hamied Department of Chemistry. The research focuses on genomics, computational biology and imaging, with interests in cancers such as breast, pancreas, brain, and colon. The Institute aims to expand the use of AI to generate research hypotheses and explore cancer biology. The Core Facilities provide access to state-of-the-art equipment, in-house expertise and training.
Project details
The student will join a team exploring the formation, dynamics and functions of four-stranded DNA G-quadruplex structures and modified DNA bases in the genome. The research includes mechanisms that regulate gene expression, DNA replication and genome stability, and how these affect cell state changes. The project emphasizes novel methods to investigate genome function, including mapping binding of nucleic acid-interacting drugs and small molecules, and genome sequencing of modified bases in relation to chromatin proteins.
Selected publications related to the group’s work include Genome Biology (2021, 2025), Nature Chemistry (2025), PNAS (2024, 2025), Nature Biotechnology (2023, 2023), and related venues.
Preferred skills/knowledge
- Strong motivation and ability to work independently and in collaboration
- Background in molecular biology and/or biochemistry
- Good knowledge of genomics and nucleic acid chemistry/chemical biology is highly desirable
Funding and duration
This is a four-year studentship funded by Cancer Research UK Cambridge Institute. It covers university fees and includes an index-linked stipend starting at £22,500 per year.
Eligibility
- Open to UK and overseas applicants
- Applications are invited from recent graduates or final-year undergraduates with a First or Upper Second Class degree (or equivalent) in a relevant subject
- Applicants with relevant research experience (Masters or laboratory work) are strongly encouraged to apply
How to apply
Apply via the University Applicant Portal. For course information and to access the Applicant Portal, visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc
You should select to commence study in Michaelmas Term (October) 2026. Include the project name and supervisor reference where indicated. You may apply for up to three projects.
Application components
- Research Experience (up to 2,500 characters)
- Statement of Interest (up to 2,500 characters) explaining motivation and relevant experience
- Academic transcripts
- Evidence of English competence (if applicable)
- Details of two academic referees
- CV/resume
Deadline and interview
Closing date: Thursday 13 November 2025. Interviews will take place on Tuesday 25 November 2025.
The University is committed to equality, diversity and inclusion and encourages applications from all sections of society. The University also has a responsibility to ensure that all employees are eligible to live and work in the UK.
CRUK CI PhD Studentship: The Structure and Function of the Genome in Cambridge employer: Cambridge Service Alliance
The Cancer Research UK Cambridge Institute is an exceptional employer, offering a dynamic and collaborative work environment that fosters innovation in cancer research. With access to cutting-edge facilities and a strong emphasis on employee development, the PhD studentship provides a unique opportunity to contribute to groundbreaking research while receiving comprehensive training and support. Located in the vibrant city of Cambridge, the Institute promotes a culture of inclusivity and encourages diverse perspectives, making it an ideal place for aspiring researchers to thrive.
StudySmarter Expert Advice🤫
We think this is how you could land CRUK CI PhD Studentship: The Structure and Function of the Genome in Cambridge
✨Tip Number 1
Network like a pro! Reach out to current or former students from the CRUK Cambridge Institute. They can give you insider info on the lab culture and what the supervisors are really like. Plus, it shows your genuine interest in the position!
✨Tip Number 2
Prepare for your interview by diving deep into the latest research in genomics and cancer biology. Familiarise yourself with the work of Professor Sir Shankar Balasubramanian and the lab's recent publications. This will help you stand out and show that you're ready to contribute.
✨Tip Number 3
Practice your pitch! Be ready to explain why you're passionate about the structure and function of the genome. Highlight any relevant experience you have, whether it's coursework, projects, or lab work. We want to see your enthusiasm shine through!
✨Tip Number 4
Don't forget to apply through our website! Make sure you follow all the application guidelines and submit everything on time. A well-organised application can make a huge difference in landing that interview!
We think you need these skills to ace CRUK CI PhD Studentship: The Structure and Function of the Genome in Cambridge
Some tips for your application 🫡
Craft a Compelling Statement of Interest:Your Statement of Interest is your chance to shine! Make sure to clearly express your motivation for the project and how your background aligns with the research. We want to see your passion for genomics and how you can contribute to our lab.
Highlight Relevant Experience:When detailing your Research Experience, focus on any relevant projects or lab work you've done. We love seeing hands-on experience, especially in molecular biology or biochemistry, so don’t hold back on showcasing your skills!
Keep it Professional but Personal:While we want your application to be professional, don’t forget to let your personality shine through! A touch of authenticity can make your application stand out. Remember, we’re looking for someone who fits well with our team.
Double-Check Your Application Components:Before hitting submit, make sure all components are included and polished. This includes your CV, academic transcripts, and references. We recommend applying through our website for a smooth process, so don’t miss out!
How to prepare for a job interview at Cambridge Service Alliance
✨Know Your Research
Dive deep into the specifics of the project you'll be working on. Familiarise yourself with the latest publications from Professor Sir Shankar Balasubramanian's lab, especially those related to G-quadruplex structures and gene regulation. This will not only show your genuine interest but also help you engage in meaningful discussions during the interview.
✨Showcase Your Skills
Be ready to discuss your background in molecular biology, biochemistry, and genomics. Prepare examples of relevant research experience or projects you've worked on. Highlight any specific techniques or methodologies you're familiar with, especially those that align with the lab's focus on DNA chemistry and imaging.
✨Prepare Thoughtful Questions
Interviews are a two-way street! Prepare insightful questions about the lab's current projects, future directions, and how they integrate AI into their research. This demonstrates your enthusiasm and critical thinking, plus it helps you assess if the lab is the right fit for you.
✨Practice Your Presentation
You might be asked to present your previous work or research ideas. Practise summarising your projects clearly and concisely, focusing on your contributions and the impact of your work. This will help you communicate effectively and leave a lasting impression on the interview panel.
