At a Glance
- Tasks: Shape Boltz Lab’s platform with deep biological insights and guide model development.
- Company: Join Boltz, a pioneering public benefit company in AI-powered molecular modeling.
- Benefits: Competitive salary, equity ownership, and significant project ownership.
- Other info: Collaborate with top talent and influence product design for real user needs.
- Why this job: Make a real-world impact by empowering thousands of scientists globally.
- Qualifications: PhD in biologics engineering or related field with hands-on experience.
The predicted salary is between 60000 - 80000 £ per year.
About Boltz
Boltz is a public benefit company building the next generation of AI-powered molecular modeling tools to make biology programmable and accelerate drug discovery, while keeping frontier capabilities broadly accessible. Boltz-1, Boltz-2, and BoltzGen are open models trusted by 100,000+ scientists across biotech and academia, and used in programs at every Top 20 pharma as well as leading agrichemical and industrial research organizations.
We deliver these capabilities through Boltz Lab, our platform for running our latest models and design agents as reliable, production-grade tools. Boltz Lab is designed around real chemistry and biology workflows, so teams can start from a target and a hypothesis and quickly generate, evaluate, and rank candidate molecules. We provide the compute, the scalable infrastructure, and the collaboration layer, so scientists can iterate faster and stay focused.
You can read more about our mission, research and product vision on our manifesto.
About the role
As a Principal Scientist in Biologics, you will play a central role in shaping Boltz Lab’s platform by bringing deep biological insight into how our machine learning systems are designed, evaluated, and used by scientists. You will ensure that the models and tools we build reflect real-world biologics engineering workflows and address the practical challenges faced by researchers working on antibodies, peptides, and other biologic modalities.
You will work closely with ML researchers and engineers to guide model development, from defining biologically meaningful objectives and datasets to interpreting model outputs and failure modes. Your scientific expertise will directly influence product decisions, helping translate cutting-edge ML research into capabilities that are intuitive, trustworthy, and impactful for scientists in the lab.
This role is ideal for a strong, product-minded scientist who wants to extend their impact beyond individual projects by shaping a platform that empowers thousands of scientists worldwide. You will set scientific direction while remaining hands-on, holding a high bar for biological rigor, thoughtful product design, and real-world impact.
About you
Essentials:
- PhD or equivalent, with additional industrial or academic research experience in biologics engineering, structural biology, protein science, bioengineering, or a closely related field.
- Strong hands-on experience designing, engineering, or characterizing biologics.
- Deep understanding of biologics discovery and optimization workflows.
- Ability to work closely with ML researchers and engineers, translating biological problems into clear modeling objectives and evaluation criteria.
- Experience interpreting computational model outputs and connecting them to biological and experimental outcomes.
- Product-minded scientific thinking, with the ability to influence platform design and roadmap decisions based on real user needs.
- Strong communication skills, able to articulate complex biological concepts to interdisciplinary teams.
Nice to have:
- Familiarity with structural modeling, docking, or protein design tools (e.g. structure prediction, scoring, or simulation workflows).
- Applied experience using Boltz models on biologic research projects.
- Interest in scaling scientific impact through platforms, tools, or open scientific infrastructure.
What we offer
Opportunity to drive outsized real-world impact by building tools that empower thousands of scientists across the industry. Work alongside one of the most talent-dense teams in the field. Significant ownership and independence, with responsibility for driving projects from concept to deployment. Highly competitive salary with substantial equity ownership.
Principal Scientist, Biologics in London employer: Boltz
Boltz is an exceptional employer, offering a unique opportunity to work at the forefront of AI-powered molecular modeling in a collaborative and innovative environment. With a strong focus on employee growth, you will have the chance to influence real-world scientific advancements while enjoying significant ownership and independence in your role. Our commitment to making cutting-edge tools accessible to thousands of scientists ensures that your work will have a meaningful impact on the future of drug discovery.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Scientist, Biologics in London
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
✨Leverage University Alumni Networks
If you're a recent grad, don’t underestimate the power of your university’s alumni network! Reach out to alumni working in biotechnology to gather tips about job openings at companies like Boltz. You'd be surprised how willing people are to help out a fellow grad!
✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like Boltz!
We think you need these skills to ace Principal Scientist, Biologics in London
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Boltz that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Boltz.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Boltz does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Boltz
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Boltz. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into Boltz's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Boltz. This shows your passion for the industry!
