At a Glance
- Tasks: Expand property prediction for ADME/DMPK models and guide data generation.
- Company: Join Boltz, a pioneering AI-driven molecular modelling company.
- Benefits: Competitive salary, equity ownership, and significant project ownership.
- Other info: Collaborate with top talent and drive projects from concept to deployment.
- Why this job: Make a real-world impact in drug discovery with cutting-edge technology.
- Qualifications: PhD with 5+ years in DMPK or related fields; strong hands-on experience required.
The predicted salary is between 63000 - 77000 £ per year.
Boltz is a public benefit company building the next generation of AI-powered molecular modeling tools to make biology programmable and accelerate drug discovery, while keeping frontier capabilities broadly accessible.
Boltz-1, Boltz-2, and Boltz Gen are open models trusted by 100,000+ scientists across biotech and academia, and used in programs at every Top 20 pharma as well as leading agrichemical and industrial research organizations.
We deliver these capabilities through Boltz Lab, our platform for running our latest models and design agents as reliable, production-grade tools.
Boltz Lab is designed around real chemistry and biology workflows, so teams can start from a target and a hypothesis and quickly generate, evaluate, and rank candidate molecules.
We provide the compute, the scalable infrastructure, and the collaboration layer, so scientists can iterate faster and stay focused.
You can read more about our mission, research and product vision on our manifesto:
About The Role
As an ADME/DMPK Researcher, you will work to expand the property prediction layer of Boltz Lab, bringing deep insight into how our models are trained, evaluated, and used by medicinal chemists.
Cofolding has changed how scientists think about structure, yet we believe ADME property prediction has not yet had its equivalent moment.
You will be the person who guides, for our ADME and DMPK models, data we generate, what we can acquire from public and proprietary sources, and how we curate + standardise the data.
You will work closely with our wider Research and ML team to build and validate ADME/DMPK models, defining meaningful objectives, defining outputs, and diagnosing failure modes when predictions and experiments disagree.
You will lead data generation and sourcing campaigns, and you will ensure the highest quality of assay provenance and data quality.
Your work will directly shape how property prediction integrates with generative design across all Boltz products, and ensure that our ADME and DMPK prediction models function for all stages of pre-clinical development work.
This role is ideal for a scientist who wants to extend their impact beyond individual programs.
You will guide scientific direction while remaining hands-on, with ML engineering support available for anything that needs to reach production.
You will be an experienced ADME/DMPK scientist who generates and analyzes ADME and DMPK data on real drug discovery programs.
Demonstrating a deep knowledge and understanding of the underlying principles behind the data and science is essential.
You should want to apply your expertise in ADME and DMPK beyond the limits of a traditional drug discovery setting.
We are not looking for a machine learning scientist, and you do not need to have trained a model.
About You
- Ph D or equivalent, with 5+ years industry experience in DMPK, pharmaceutical sciences, bioanalysis, medicinal chemistry, or a closely related field.
- Strong hands on experience owning ADME optimization on real drug discovery programs, with expert knowledge of Tier 1 and Tier 2 in vitro assays and their limitations.
- Demonstrated depth in ADME and DMPK data, including protocol differences between laboratories, nuances in assay variation, and when to question assay outputs.
- Experience specifying and overseeing assay work with CROs or internal laboratories, including protocol design.
- Ability to work across disciplines, translating ADME/DMPK insights into clear modeling objectives and evaluation criteria, and translating model behaviour back into actionable decisions.
- Product minded scientific thinking, with the ability to influence platform design and roadmap decisions based on real user needs.
- Nice to have
- Experience curating bioactivity data alongside ADME endpoints - binding and functional assays, potency measures that are not interchangeable, and the judgment to know what can be pooled and what cannot.
- Strong operational experience in scientific data acquisition, including identifying relevant public, commercial, and proprietary datasets; engaging with data providers and CROs; evaluating dataset quality and fit for purpose; and driving acquisition, transfer, and integration through to a usable internal dataset.
What We Offer
- Opportunity to drive outsized real world impact by building tools that empower thousands of scientists across the industry.
- Work alongside one of the most talent dense teams in the field.
- Significant ownership and independence, with responsibility for driving projects from concept to deployment.
- Highly competitive salary with substantial equity ownership.
ADME/DMPK Scientist employer: Boltz
Boltz is an exceptional employer for MLOps Engineers, offering a unique opportunity to work at the forefront of AI-powered molecular modeling in London. With a strong focus on employee growth, you will enjoy significant ownership of projects and the chance to collaborate with some of the brightest minds in the industry, all while contributing to impactful scientific advancements. The company fosters a culture of innovation and excellence, providing competitive salaries and equity ownership, making it an attractive place for those seeking meaningful and rewarding employment.
StudySmarter Expert Advice🤫
We think this is how you could land ADME/DMPK Scientist
✨Unlock Networking Opportunities
Dive into industry-specific events like pharmaceutical conferences and seminars, where you can meet hiring managers from companies like Boltz. These are goldmines for making connections and learning about job openings before they hit the mainstream job boards.
✨Join Relevant Professional Bodies
Get involved with organisations such as the Royal Pharmaceutical Society or your local pharmaceutical professionals' network. Being an active member can boost your credibility and may even lead to job referrals in top organisations like Boltz.
✨Leverage Internships for Full-time Roles
If you can, consider pursuing internships in the pharmaceutical industry, especially with companies like Boltz. These opportunities often pave the way for full-time positions and allow you to demonstrate your capabilities firsthand.
✨Tailor Your Approach
When you're applying for roles, don't rush it! Take the time to customise your applications for specific positions, showcasing relevant skills and experiences that align with what Boltz is looking for. A tailored application can really make you stand out!
We think you need these skills to ace ADME/DMPK Scientist
Some tips for your application 🫡
Showcase Your Relevant Experience:When applying for a role in the pharmaceutical industry, it's crucial to highlight any relevant experience you have. Whether that's internships, lab work, or even related coursework, make sure to weave this into your CV and cover letter. We want to see how your background aligns with the role you're applying for at Boltz!
Emphasise Your Understanding of Regulations:The pharmaceutical industry is heavily regulated, so it's important to indicate your familiarity with industry standards and regulations. In your cover letter, mention any training or certifications you've received that are relevant, or discuss projects where you’ve navigated compliance. This will show Boltz that you're not just a fit for the job but also a safety-conscious candidate!
Tailor Your CV to Be Result-Driven:Craft your CV to highlight quantifiable achievements, especially if you have previous roles in pharmaceuticals or related fields. Use metrics to demonstrate your impact, such as improved processing times or successful project completions while working on trials. This analytical approach will resonate well with hiring managers at Boltz!
Convey Your Passion for the Industry:In your cover letter, express why you are passionate about working in the pharmaceutical sector. Whether it’s your desire to contribute to groundbreaking drug research or improve patient outcomes, let it shine through! At Boltz, we value candidates who are truly enthusiastic about their work—you might just stand out from the crowd.
How to prepare for a job interview at Boltz
✨Understand the Science
Make sure you brush up on key pharmaceutical concepts and recent developments in the industry. You might get asked some technical questions during the interview at Boltz that show your grasp of drug development processes or regulatory requirements, so be ready to discuss them clearly.
✨Showcase Relevant Experience
If you have any hands-on experience or internships in a laboratory setting, be sure to highlight these in your responses. Think about the projects you worked on, the methodologies you used, and the impact you made. It's all about telling a story that connects your background to the role you're applying for.
✨Know Their Products
Take some time to familiarise yourself with Boltz’s product range and recent breakthroughs. Understanding their portfolio not only shows your enthusiasm for the role but also allows you to ask insightful questions that demonstrate your interest in actively contributing to their projects.
✨Be Ready for Regulatory Scenarios
In a full-time pharmaceutical role, understanding the regulatory landscape is crucial. Prepare for situational questions that may test your problem-solving skills concerning compliance and safety standards. You could be asked how you'd handle a hypothetical issue regarding a drug’s market release, so think through your approach.
