Head of Pipeline Biology in England

Job Description

We are seeking an innovative and hands‑on scientific leader to serve as Head of Pipeline Biology , responsible for advancing the biological development of our client\’s pioneering bispecific TCR therapeutics targeting AML and solid tumours. This is a critical leadership role in progressing first‑in‑class, first-in‑human molecules to the clinic.

Key Responsibilities

Scientific Leadership & Strategy

• Lead the preclinical biology group, overseeing in vitro and in vivo testing of bispecific TCR molecules.
• Design and implement assays to assess binding specificity, T cell activation, and T cell-mediated killing.
• Develop testing strategies to evaluate efficacy, safety, and mechanism of action.
• Collaborate with Protein Engineering to optimise candidate molecules.

Regulatory & Translational Development

• Drive the generation of data packages to support regulatory submissions (MHRA, FDA, EMA).
• Contribute to Clinical Trial Authorisation (CTA) and IND / NDA applications.
• Engage with regulatory bodies and external experts to ensure alignment with global standards.

Team & Operational Leadership

• Manage and mentor a growing team of cell biologists (initially 3–4 scientists).

Oversee budgets, timelines, and reporting for biological test…

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