Research Assistant, Discovery Screening in Cambridge

bit.bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At bit.bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics. As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.

Location: Babraham Research Campus, Cambridge

Type: Full time, permanent

Start: Immediate

This role does not meet the minimum salary requirements for UK skilled worker sponsorship. Candidates must already have the right to work in the UK or must not require sponsorship for a Skilled Worker visa.

Your role in our team:

Reporting to the Director of Discovery Screening, the Research Assistant will perform, document and evaluate genetic screens aimed at identifying reprogramming factors in human iPSCs and mammalian cell lines to achieve team goals and broader project objectives. This role focuses on supporting the technological development of novel and existing screening platforms, alongside coordinating the implementation of new technologies and Standard Operating Procedures (SOPs) in alignment with company-wide goals.

Your key responsibilities will include:

• Perform genetic screens aimed at identifying programming factors in human iPSCs and mammalian cell lines, taking responsibility for sample tracking and quality control (QC).
• Perform experimental work aimed to develop and expand the team's capabilities.
• Perform molecular biology techniques and molecular/cell phenotyping assays, including PCR, ddPCR, and flow cytometry.
• Monitor day-to-day lab activities, maintain tissue culture reagent stock levels, ensure equipment is properly maintained, and adhere strictly to good lab practice standards.
• Contribute to the development and implementation of new technologies, workflows, and operational infrastructure.
• Document and report activities in a precise, timely, and exhaustive fashion.
• Communicate outcomes of experimental work to team and department both in oral and written form.
• Draft key technical documentation, including Tech Transfers, SOPs, and Data Packages.
• Stay up to date with key aspects of genetic engineering, vector assembly, cell line engineering processes, and next-generation sequencing.

Hold a minimum Bachelor’s degree qualification (or equivalent experience) in a relevant field of Biological Science and experience in a related Research Assistant role. A meticulous approach and attention to detail are required. Proven ability to communicate research and project outputs effectively (written and verbally).

With essential experience in…

• Practical and theoretical background in mammalian cell culture and engineering/gene editing.
• Practical experience of molecular biology techniques (e.g., PCR) and molecular/cell phenotyping assays (e.g. ddPCR).

…and possibly…

• Experience in executing and optimising large scale screening protocols.
• Good knowledge and experience of high-throughput genomic screening technologies and automated tissue culture workflows (e.g. 96/384 well plates).
• Practical and theoretical background in human iPSC culture and engineering/gene editing.
• Experience executing flow cytometry experiments (e.g., choosing fluorophores, compensation controls) and analysing/interpreting FACS data.
• Knowledge and experience with reporting via electronic lab notebooks (e.g. Benchling) and sample tracking.

More reasons to join us: bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact. We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other. Creativity and open minds are encouraged for everyone to contribute to the success of the company.

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