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- Tasks: Lead non-clinical PKPD studies and collaborate on innovative drug development projects.
- Company: Global biopharma organisation with a focus on early clinical development.
- Benefits: Competitive hourly rate, remote work, and potential for contract extension.
- Why this job: Make a real impact in drug development and enhance your scientific reputation.
- Qualifications: PhD, MSc, or BSc in relevant fields with 5+ years of PKPD experience.
- Other info: Dynamic role with opportunities for collaboration and career growth.
The predicted salary is between 70000 - 90000 £ per year.
Principal Scientist – Non-Clinical PKPD (Contract)
UK (Slough-based, VDI only – remote access provided) | 12-month contract |Full-time (37.5 hrs/week) | £35.20–£47.92/hr (PAYE/LTD/Umbrella)
We are supporting a global biopharma organisation seeking an experienced Principal Scientist, Non-Clinical PKPD to join their Early Clinical Development & Translational Sciences group on a 12-month contract.
This role sits within the Quantitative Clinical Pharmacology function, which integrates PK/PD, systems modelling, clinical pharmacology, and DMPK approaches across the full drug development lifecycle. The position offers an excellent opportunity for a skilled pharmacokinetics/pharmacodynamics scientist to contribute to innovative drug development projects from preclinical through regulatory submission.
Key Responsibilities
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Lead strategy and execution of non-clinical PKPD and GLP toxicokinetic studies.
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Provide scientific input into study protocols and regulatory study designs.
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Collaborate cross-functionally with Non-Clinical Safety, Bioanalysis, Clinical Pharmacology, and external CRO partners.
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Ensure delivery of high-quality data packages that meet GLP and regulatory submission standards.
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Analyse, interpret, and report PKPD/toxicokinetic study results; deliver reports and summaries for regulatory submissions.
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Effectively communicate interim and final results to project teams and stakeholders.
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Represent the function internally and externally, contributing to scientific reputation and best practices.
Candidate Profile
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PhD, MSc, or BSc in pharmacology, quantitative pharmacology, pharmacokinetics/pharmacodynamics, DMPK, or related field.
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5+ years’ hands-on PKPD data analysis experience within pharma or CRO environments.
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Strong knowledge of pharmacology and drug mechanisms.
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Proven ability to design and deliver non-clinical PKPD studies and GLP toxicokinetics reports.
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Proficiency with Phoenix WinNonlin is essential; experience with modelling/simulation tools (e.g., Berkeley Madonna, R) a plus.
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Track record of regulatory submissions and/or scientific publications desirable.
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Strong communication skills with the ability to influence and collaborate in a matrix environment.
Contract Details
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Duration: 12 months (potential extension).
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Hours: 37.5 per week (7.5 per day).
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Location: UK-based; virtual desktop infrastructure (VDI only). Candidate provides own equipment. Future office relocation to Surrey anticipated in 2026/27.
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UK - Principal Scientist PKPD Non Clin employer: BioTalent Ltd
Contact Detail:
BioTalent Ltd Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land UK - Principal Scientist PKPD Non Clin
✨Tip Number 1
Network like a pro! Reach out to your connections in the biopharma industry, especially those who work in PKPD or related fields. A friendly chat can lead to insider info about job openings or even referrals.
✨Tip Number 2
Prepare for interviews by brushing up on your PKPD knowledge and recent advancements in the field. We recommend practising common interview questions and having examples ready that showcase your experience in non-clinical studies.
✨Tip Number 3
Don’t underestimate the power of follow-ups! After an interview, send a quick thank-you email to express your appreciation and reiterate your interest in the role. It keeps you fresh in their minds!
✨Tip Number 4
Apply through our website for the best chance at landing that Principal Scientist role. We make it easy for you to showcase your skills and experience directly to the hiring team!
We think you need these skills to ace UK - Principal Scientist PKPD Non Clin
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to highlight your experience in PKPD and non-clinical studies. We want to see how your skills align with the role, so don’t be shy about showcasing relevant projects and achievements!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your background makes you the perfect fit. We love seeing enthusiasm and a clear understanding of the position.
Showcase Your Communication Skills: Since strong communication is key for this role, make sure to demonstrate your ability to convey complex information clearly in your application. Whether it’s through your CV or cover letter, let us see your knack for effective communication!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands. Plus, it shows us you’re keen on joining our team at StudySmarter!
How to prepare for a job interview at BioTalent Ltd
✨Know Your PKPD Inside Out
Make sure you brush up on your pharmacokinetics and pharmacodynamics knowledge. Be ready to discuss specific studies you've led or contributed to, and how they align with the role's requirements. This will show that you're not just familiar with the concepts but can apply them effectively.
✨Prepare for Technical Questions
Expect some technical questions related to GLP toxicokinetics and study design. Review your experience with Phoenix WinNonlin and any modelling tools you've used. Being able to articulate your thought process during these discussions will demonstrate your expertise and confidence.
✨Showcase Your Collaboration Skills
This role involves working cross-functionally, so be prepared to share examples of how you've successfully collaborated with teams in the past. Highlight any experiences where you influenced project outcomes or improved processes through teamwork.
✨Communicate Clearly and Effectively
Since you'll need to report results and communicate findings, practice summarising complex data in a clear and concise manner. Think about how you would present your previous work to stakeholders who may not have a deep scientific background. Good communication can set you apart!
