Senior Manager, Lead Executive Assistant in Cambridge

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating nuzafatide pevedotin (formerly 5528), a Bicycle Drug Conjugate (BDC) targeting EphA2; zelenectide pevedotin (formerly BT8009), a BDC targeting Nectin-4; and BT7480, a Bicycle Tumor‐Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin‐4 and agonizing CD137, in company‐sponsored clinical trials. Additionally, the company is developing Bicycle Radioconjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.

Your mission is to act as a business partner and force multiplier for the CEO and key members of the Executive Team. You will provide seamless, forward‐thinking executive support that anticipates needs and clears the path for our leaders to focus on driving Bicycle's mission. As a highly experienced EA, you will set the standard for administrative excellence across the company, acting as a key mentor and coordination point for the EA community and driving the function forward through your own world‐class performance.

To best support our executive team and act as a key connector for our colleagues, this role requires a regular on‐site presence with the CEO and other Executives and will be based on‐site in our Cambridge office. Flexibility to travel to London and other sites occasionally may be required.

Your Responsibilities

• Provides comprehensive, proactive administrative and coordination support to the CEO and other executives.
• Expertly manage and triage complex, fluid calendars for the CEO, Chief Corporate Development Officer (CCDO), Chief Legal Officer (CLO), and Chief of Staff.
• Arrange complex international travel, itineraries, and meeting logistics.
• Prepare agendas, briefing materials, and coordinate presentations for key executive meetings.
• Manage and submit accurate and timely expense reports on behalf of the executives.
• Serve as a key gatekeeper and point of contact for the executive office.
• Lead and manage all coordination for Board of Directors meetings and related activities.
• Act as the central point of coordination and collaborative partner for the Executive Assistant team.
• Proactively identify and implement new tools, systems, and processes to improve efficiency and collaboration.
• Independently lead and manage key projects on behalf of the executive office and Chief of Staff.

Who you are: Skills & Competencies

• You are a recognised expert in C‐suite executive support.
• You provide foresight and strategic interpretation of executive priorities.
• You act as a catalyst for collaboration within the EA community.
• You oversee a complex portfolio of executive support activities.
• You resolve complex organisational challenges in scheduling and logistics.
• You operate with broad independence, setting direction for administrative priorities.
• You make high-impact decisions with long-term implications.
• You act as a senior mentor and coach for the EA community.

Qualifications

• A proven track record of providing executive‐level support to C‐suite leaders.
• Experience within the BioTech, BioPharma, or life sciences industry is essential.
• Exceptional organisational and project management skills.
• The ability to act as a true business partner.
• A natural collaborator and mentor.
• Unquestionable discretion and experience handling highly confidential information.

Additional Information

• State‐of‐the‐art campus environment with on campus restaurant and Montessori nursery.
• Flexible working environment.
• Competitive reward including annual company bonus.
• Employee recognition schemes.
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually.
• Employer contribution to pension.
• Life assurance cover 4x basic salary.
• Private Medical Insurance, including optical and dental cover.
• Enhanced parental leave policies.
• Group income protection.
• Employee assistance program.
• Health Cash Plan.
• Access to company subsidised gym membership.
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Cycle to work scheme.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company.