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- Tasks: Design and deliver innovative Bicycle® molecules for groundbreaking cancer therapies.
- Company: Join a pioneering pharmaceutical company transforming medicine with cutting-edge technology.
- Benefits: Competitive salary, health benefits, and opportunities for professional growth.
- Other info: Collaborative culture focused on adventure, dedication, and teamwork.
- Why this job: Make a real difference in patients' lives by advancing novel drug candidates.
- Qualifications: Expertise in synthetic and medicinal chemistry required.
The predicted salary is between 60000 - 80000 £ per year.
Company Description
Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating nuzafatide pevedotin (formerly 5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; zelenectide pevedotin (formerly BT8009), a BDC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radioconjugates (BRC®) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology. Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit bicycletherapeutics.com.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
- We are One Team. We only succeed when we work together.
Job Description
Your mission is to apply your deep expertise in synthetic and medicinal chemistry to design and deliver novel Bicycle® molecules and conjugates. As a key member of our project teams, you will take a leading role in chemistry workstreams, manage external CROs, and contribute significantly to the progression of our oncology pipeline, helping to deliver the next wave of clinical candidates for patients.
Responsibilities: Scientific Strategy
Associate Principal Scientist, Medicinal Chemistry employer: Bicycle Therapeutics
Contact Detail:
Bicycle Therapeutics Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Associate Principal Scientist, Medicinal Chemistry
✨Tip Number 1
Network like a pro! Reach out to professionals in the medicinal chemistry field on LinkedIn or at industry events. We can’t stress enough how valuable personal connections can be in landing that dream job.
✨Tip Number 2
Prepare for interviews by brushing up on your knowledge of Bicycle® molecules and their applications. We recommend practising common interview questions and having a few insightful questions ready to show your genuine interest in the company’s mission.
✨Tip Number 3
Showcase your passion for the role! During interviews, share specific examples of your previous work in synthetic and medicinal chemistry. We want to see how your experience aligns with our adventurous spirit and dedication to innovation.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, it shows you’re serious about joining our team and contributing to our mission of delivering extraordinary results for patients.
We think you need these skills to ace Associate Principal Scientist, Medicinal Chemistry
Some tips for your application 🫡
Show Your Passion: When writing your application, let your enthusiasm for medicinal chemistry shine through. We want to see that you’re not just qualified, but genuinely excited about the work we do at Bicycle Therapeutics.
Tailor Your CV: Make sure your CV is tailored to highlight your relevant experience in synthetic and medicinal chemistry. We love seeing how your background aligns with our mission and the specific role of Associate Principal Scientist.
Craft a Compelling Cover Letter: Your cover letter is your chance to tell us why you’re the perfect fit for our team. Be sure to mention how your skills can contribute to our innovative projects and how you embody our company values.
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands and shows us you’re serious about joining our adventurous team!
How to prepare for a job interview at Bicycle Therapeutics
✨Know Your Chemistry
Make sure you brush up on your synthetic and medicinal chemistry knowledge. Be prepared to discuss specific techniques and methodologies you've used in previous roles, especially those relevant to designing novel molecules. This will show your expertise and how it aligns with the company's mission.
✨Understand Bicycle's Technology
Familiarise yourself with Bicycle Therapeutics' unique approach to drug development, particularly their Bicycle® molecules and BDCs. Being able to articulate how these innovations can impact oncology will demonstrate your genuine interest in the company and its goals.
✨Showcase Teamwork Skills
Since collaboration is key at Bicycle, be ready to share examples of how you've successfully worked in teams. Highlight any experiences where you managed external CROs or collaborated across disciplines, as this will resonate with their value of being 'One Team'.
✨Embrace the Company Culture
Research Bicycle's values: Adventurous, Dedicated, and One Team. Think of ways you embody these values in your work. During the interview, weave these principles into your responses to show that you're not just a fit for the role, but also for the company culture.