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- Tasks: Lead PK/PD modelling strategies for drug development and collaborate with cross-functional teams.
- Company: Join a science-driven organisation focused on transformative therapies and innovative solutions.
- Benefits: Enjoy competitive salary, comprehensive benefits, and flexible work arrangements.
- Why this job: Make a real impact in drug development while growing your expertise in a collaborative environment.
- Qualifications: PhD or MSc with 5-8 years of PK/PD modelling experience; proficiency in relevant software tools required.
- Other info: Opportunity to mentor junior scientists and contribute to scientific publications.
The predicted salary is between 54000 - 84000 £ per year.
We are seeking an experienced and driven Senior PK/PD Modeller to join our Clinical Pharmacology team. In this role, you will be responsible for the design, development, and implementation of pharmacokinetic/pharmacodynamic (PK/PD) modeling strategies to support drug development across all phases. You will collaborate cross-functionally with pharmacometrics, clinical, regulatory, and nonclinical teams to provide quantitative insight into drug behavior and inform key decision-making.
Key Responsibilities:
- Lead the development and execution of PK/PD modeling and simulation strategies for preclinical and clinical programs.
- Perform population pharmacokinetics (PopPK), exposure-response (E-R), and physiologically-based pharmacokinetic (PBPK) modeling.
- Translate complex quantitative data into actionable insights for dose selection, trial design, and regulatory interactions.
- Author or contribute to clinical study protocols, pharmacometric analysis plans, and regulatory submissions (IND, NDA, BLA, MAA, etc.).
- Serve as subject matter expert in modeling approaches and mentor junior scientists in PK/PD methodologies.
- Collaborate with biostatistics, clinical pharmacology, regulatory affairs, and other key stakeholders to integrate modeling insights into overall development strategy.
- Maintain awareness of new scientific and regulatory developments in pharmacometrics and contribute to external publications and presentations when appropriate.
Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacology, Applied Mathematics, Biomedical Engineering, or related field; or PharmD/MSc with significant modeling experience.
- Minimum of 5–8 years of hands-on experience in PK/PD modeling, preferably within the pharmaceutical or biotechnology industry.
- Proficiency in NONMEM, Monolix, R, Phoenix WinNonlin, MATLAB, or other relevant software tools.
- Strong understanding of regulatory guidance and expectations related to modeling and simulation (e.g., FDA, EMA).
- Demonstrated ability to interpret and communicate complex data effectively to both technical and non-technical stakeholders.
- Track record of contributions to regulatory filings and/or scientific publications.
- Strong analytical, organizational, and project management skills.
Preferred Skills:
- Experience in mechanistic modeling or QSP (Quantitative Systems Pharmacology).
- Familiarity with PBPK modeling platforms (e.g., Simcyp, GastroPlus).
- Experience in oncology, CNS, immunology, or other specific therapeutic areas is a plus.
- Leadership in cross-functional project teams.
Why Join Us?
You’ll be part of a collaborative and innovative environment where your expertise will directly impact the development of transformative therapies. We offer a competitive salary, comprehensive benefits, flexible work arrangements, and the opportunity to grow professionally in a science-driven organization.
Senior PKPD Modeller employer: Barrington James
Contact Detail:
Barrington James Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior PKPD Modeller
✨Tip Number 1
Network with professionals in the pharmacometrics and clinical pharmacology fields. Attend industry conferences or webinars to meet potential colleagues and learn about the latest trends in PK/PD modelling.
✨Tip Number 2
Showcase your expertise in relevant software tools like NONMEM, Monolix, and R during interviews. Be prepared to discuss specific projects where you successfully applied these tools to solve complex modelling challenges.
✨Tip Number 3
Familiarise yourself with recent regulatory guidelines from agencies like the FDA and EMA. Being able to discuss how these guidelines impact PK/PD modelling will demonstrate your up-to-date knowledge and commitment to the field.
✨Tip Number 4
Prepare to articulate your experience in cross-functional collaboration. Highlight instances where you've worked with biostatistics, clinical teams, or regulatory affairs to integrate modelling insights into drug development strategies.
We think you need these skills to ace Senior PKPD Modeller
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your relevant experience in PK/PD modelling. Emphasise your hands-on experience with software tools like NONMEM, Monolix, and R, as well as any contributions to regulatory filings or scientific publications.
Craft a Strong Cover Letter: In your cover letter, express your passion for pharmacometrics and drug development. Mention specific projects where you led PK/PD modelling efforts and how they contributed to successful outcomes. This is your chance to showcase your communication skills.
Highlight Collaborative Experience: Since the role involves cross-functional collaboration, be sure to include examples of how you've worked with teams from different disciplines. Discuss your experience mentoring junior scientists and how you’ve integrated modelling insights into development strategies.
Showcase Continuous Learning: Mention any recent training, workshops, or conferences you've attended related to pharmacometrics or regulatory guidance. This demonstrates your commitment to staying updated on scientific and regulatory developments in the field.
How to prepare for a job interview at Barrington James
✨Showcase Your Technical Skills
Make sure to highlight your proficiency in relevant software tools like NONMEM, Monolix, and R during the interview. Be prepared to discuss specific projects where you applied these skills, as this will demonstrate your hands-on experience in PK/PD modelling.
✨Understand Regulatory Expectations
Familiarise yourself with the regulatory guidance related to modelling and simulation, such as FDA and EMA expectations. Being able to articulate how your work aligns with these guidelines will show that you are not only technically skilled but also aware of the broader context of drug development.
✨Prepare for Cross-Functional Collaboration
Since the role involves collaboration with various teams, think of examples from your past experiences where you successfully worked with cross-functional teams. Highlight your communication skills and how you translated complex data into actionable insights for different stakeholders.
✨Demonstrate Leadership and Mentorship
If you have experience mentoring junior scientists or leading project teams, be sure to mention it. Discuss how you fostered a collaborative environment and contributed to the professional growth of others, as this aligns with the responsibilities of the Senior PK/PD Modeller role.
