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- Tasks: Lead PK/PD modelling strategies for drug development and collaborate with cross-functional teams.
- Company: Join a science-driven organisation focused on developing transformative therapies.
- Benefits: Enjoy competitive salary, comprehensive benefits, and flexible work arrangements.
- Why this job: Make a real impact in drug development while growing your expertise in a collaborative environment.
- Qualifications: PhD or relevant degree with 5-8 years of PK/PD modelling experience required.
- Other info: Opportunity to mentor junior scientists and contribute to scientific publications.
The predicted salary is between 48000 - 72000 £ per year.
We are seeking an experienced and driven Senior PK/PD Modeller to join our Clinical Pharmacology team. In this role, you will be responsible for the design, development, and implementation of pharmacokinetic/pharmacodynamic (PK/PD) modeling strategies to support drug development across all phases. You will collaborate cross-functionally with pharmacometrics, clinical, regulatory, and nonclinical teams to provide quantitative insight into drug behavior and inform key decision-making.
Key Responsibilities:
- Lead the development and execution of PK/PD modeling and simulation strategies for preclinical and clinical programs.
- Perform population pharmacokinetics (PopPK), exposure-response (E-R), and physiologically-based pharmacokinetic (PBPK) modeling.
- Translate complex quantitative data into actionable insights for dose selection, trial design, and regulatory interactions.
- Author or contribute to clinical study protocols, pharmacometric analysis plans, and regulatory submissions (IND, NDA, BLA, MAA, etc.).
- Serve as subject matter expert in modeling approaches and mentor junior scientists in PK/PD methodologies.
- Collaborate with biostatistics, clinical pharmacology, regulatory affairs, and other key stakeholders to integrate modeling insights into overall development strategy.
- Maintain awareness of new scientific and regulatory developments in pharmacometrics and contribute to external publications and presentations when appropriate.
Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacology, Applied Mathematics, Biomedical Engineering, or related field; or PharmD/MSc with significant modeling experience.
- Minimum of 5–8 years of hands-on experience in PK/PD modeling, preferably within the pharmaceutical or biotechnology industry.
- Proficiency in NONMEM, Monolix, R, Phoenix WinNonlin, MATLAB, or other relevant software tools.
- Strong understanding of regulatory guidance and expectations related to modeling and simulation (e.g., FDA, EMA).
- Demonstrated ability to interpret and communicate complex data effectively to both technical and non-technical stakeholders.
- Track record of contributions to regulatory filings and/or scientific publications.
- Strong analytical, organizational, and project management skills.
Preferred Skills:
- Experience in mechanistic modeling or QSP (Quantitative Systems Pharmacology).
- Familiarity with PBPK modeling platforms (e.g., Simcyp, GastroPlus).
- Experience in oncology, CNS, immunology, or other specific therapeutic areas is a plus.
- Leadership in cross-functional project teams.
Why Join Us? You’ll be part of a collaborative and innovative environment where your expertise will directly impact the development of transformative therapies. We offer a competitive salary, comprehensive benefits, flexible work arrangements, and the opportunity to grow professionally in a science-driven organization.
Senior PKPD Modeller employer: Barrington James
Contact Detail:
Barrington James Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior PKPD Modeller
✨Tip Number 1
Network with professionals in the pharmacometrics and clinical pharmacology fields. Attend industry conferences or webinars where you can meet potential colleagues and learn about the latest trends in PK/PD modelling.
✨Tip Number 2
Showcase your expertise in relevant software tools like NONMEM, Monolix, and R by engaging in online forums or contributing to open-source projects. This will not only enhance your skills but also demonstrate your commitment to the field.
✨Tip Number 3
Stay updated on regulatory guidance from agencies like the FDA and EMA. Understanding their expectations will help you articulate how your modelling strategies align with industry standards during interviews.
✨Tip Number 4
Prepare to discuss your past contributions to regulatory filings and scientific publications. Be ready to explain how your work has influenced drug development decisions, as this will highlight your value to our team.
We think you need these skills to ace Senior PKPD Modeller
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your relevant experience in PK/PD modelling, particularly any hands-on experience with software tools like NONMEM or Monolix. Emphasise your contributions to regulatory filings and scientific publications.
Craft a Strong Cover Letter: In your cover letter, clearly articulate your passion for pharmacometrics and how your background aligns with the responsibilities of the Senior PKPD Modeller role. Mention specific projects where you successfully led modelling strategies.
Showcase Your Technical Skills: Be explicit about your proficiency in relevant software tools and methodologies. Include examples of how you've used these skills to inform decision-making in drug development.
Highlight Collaborative Experience: Since the role involves cross-functional collaboration, provide examples of how you've worked with different teams, such as biostatistics or regulatory affairs, to integrate modelling insights into development strategies.
How to prepare for a job interview at Barrington James
✨Showcase Your Technical Skills
Make sure to highlight your proficiency in relevant software tools like NONMEM, Monolix, and R during the interview. Be prepared to discuss specific projects where you applied these skills, as this will demonstrate your hands-on experience in PK/PD modeling.
✨Prepare for Cross-Functional Collaboration
Since the role involves working with various teams, be ready to discuss your experience in cross-functional collaboration. Share examples of how you've effectively communicated complex data to both technical and non-technical stakeholders, showcasing your ability to bridge gaps between different departments.
✨Understand Regulatory Expectations
Familiarise yourself with the latest regulatory guidance related to pharmacometrics. During the interview, express your knowledge of FDA and EMA expectations, and be prepared to discuss how you've contributed to regulatory submissions in the past.
✨Demonstrate Leadership and Mentorship
As a Senior PK/PD Modeller, you'll likely be expected to mentor junior scientists. Share your experiences in leadership roles or mentoring situations, highlighting how you've guided others in PK/PD methodologies and contributed to their professional development.
