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- Tasks: Lead and manage recombinant protein production operations in a dynamic environment.
- Company: Leading UK-based CDMO specialising in biologics and recombinant protein production.
- Benefits: Competitive salary, performance bonus, 25+ days holiday, private healthcare, and career development.
- Why this job: Join a collaborative team and make a real impact in biotech and pharma.
- Qualifications: Degree in Biochemistry or related field with 5+ years in GMP biologics manufacturing.
- Other info: Flexible working options and a culture of innovation await you.
The predicted salary is between 36000 - 60000 £ per year.
Overview
About Us
We are a leading UK-based Contract Development and Manufacturing Organization (CDMO) specialising in biologics, with a focus on recombinant protein production for therapeutic, diagnostic, and research applications. Our state-of-the-art GMP-compliant facilities, expert teams, and customer-centric approach support global biotech and pharma clients from early development through to commercial supply.
Role Overview
As Production Manager – Recombinant Protein, you will lead the planning, coordination, and execution of protein manufacturing operations within our GMP and non-GMP production suites. You will manage a team of upstream and downstream scientists and technicians, oversee technology transfer from process development, and ensure manufacturing activities are delivered on time, within budget, and to the highest quality and regulatory standards.
This is a key leadership role that combines operational excellence with deep technical expertise in recombinant protein production (bacterial, yeast, or mammalian expression systems).
Key Responsibilities
- Lead and manage the daily operations of the recombinant protein production team (upstream and downstream).
- Plan and coordinate manufacturing campaigns for client projects, ensuring timelines, quality, and compliance goals are met.
- Oversee technology transfer from process development and ensure scalability and process robustness for GMP manufacturing.
- Maintain GMP compliance and ensure batch records, deviations, and change controls are accurately completed and reviewed.
- Drive continuous improvement in manufacturing processes, efficiency, and documentation.
- Collaborate cross-functionally with QA, QC, MSAT, Engineering, and Project Management to ensure seamless project delivery.
- Support client audits, regulatory inspections (e.g., MHRA), and contribute to CMC documentation when required.
- Mentor, develop, and manage a high-performing team, including shift leads, scientists, and production technicians.
Requirements
- Degree in Biochemistry, Biotechnology, or related life science discipline.
- Significant experience (5+ years) in GMP biologics manufacturing, ideally within a CDMO or biotech environment.
- Hands-on knowledge of recombinant protein production using bacterial (e.g., E. coli), yeast, or mammalian expression systems.
- Proven leadership experience managing production teams and delivering complex manufacturing projects.
- Strong understanding of GMP, regulatory requirements, and quality systems.
- Excellent problem-solving, organizational, and communication skills.
- Experience with single-use technologies (e.g., bioreactors, chromatography skids).
- Familiarity with electronic batch records (EBR), MES, or LIMS systems.
- Experience in tech transfer and process scale-up.
- Knowledge of viral clearance, fill/finish, or cell therapy would be advantageous.
What We Offer
- Competitive salary and performance bonus
- 25+ days holiday + bank holidays
- Private healthcare and pension schemes
- Career development and training opportunities
- Collaborative and innovative working culture
- Flexible working options (where possible)
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Production Manager - Recombinant Protein employer: Barrington James
Contact Detail:
Barrington James Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Production Manager - Recombinant Protein
✨Tip Number 1
Network like a pro! Reach out to industry contacts on LinkedIn or attend relevant events. We all know that sometimes it’s not just what you know, but who you know that can help you land that dream job.
✨Tip Number 2
Prepare for interviews by researching the company and its culture. We want to see you shine, so practice common interview questions and think about how your experience in recombinant protein production aligns with their needs.
✨Tip Number 3
Showcase your skills! Bring examples of your past work, especially any projects related to GMP biologics manufacturing. We love seeing how you’ve tackled challenges and driven improvements in your previous roles.
✨Tip Number 4
Don’t forget to follow up after your interview! A quick thank-you email can go a long way. It shows your enthusiasm for the role and keeps you fresh in their minds. And remember, apply through our website for the best chance!
We think you need these skills to ace Production Manager - Recombinant Protein
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Production Manager role. Highlight your experience in GMP biologics manufacturing and any leadership roles you've held. We want to see how your background aligns with our focus on recombinant protein production.
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about recombinant protein production and how your skills can contribute to our team. Keep it concise but impactful, showing us your personality and enthusiasm.
Showcase Relevant Experience: When detailing your experience, focus on specific projects or achievements that relate to the key responsibilities of the role. We love seeing examples of how you've led teams or improved processes in previous positions.
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it shows us you’re keen on joining our innovative team!
How to prepare for a job interview at Barrington James
✨Know Your Stuff
Make sure you brush up on your knowledge of recombinant protein production, especially the different expression systems like bacterial, yeast, and mammalian. Be ready to discuss your hands-on experience and how it relates to the role.
✨Showcase Your Leadership Skills
As a Production Manager, you'll need to demonstrate your leadership abilities. Prepare examples of how you've successfully managed teams in the past, tackled challenges, and delivered projects on time and within budget.
✨Understand GMP Compliance
Familiarise yourself with GMP regulations and quality systems. Be prepared to discuss how you've maintained compliance in previous roles and how you would ensure that batch records and deviations are handled correctly.
✨Prepare for Cross-Functional Collaboration
This role involves working closely with various departments. Think of examples where you've collaborated with QA, QC, or engineering teams to achieve project goals. Highlight your communication skills and ability to work in a team.
