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For Companies At a Glance
- Tasks: Lead clinical trials, ensuring safety and compliance while mentoring research staff.
- Company: Join a dynamic UK clinical research team focused on high-impact studies.
- Benefits: Enjoy a flexible hybrid work model, competitive salary, and professional development opportunities.
- Why this job: Make a real difference in patient care while working in a supportive, collaborative environment.
- Qualifications: Medical degree with GMC registration; experience as a Principal Investigator preferred.
- Other info: This role combines remote work with essential on-site responsibilities for a balanced approach.
The predicted salary is between 54000 - 84000 £ per year.
About the Role
We are seeking a dedicated and experienced Principal Investigator (PI) to join our expanding UK clinical research team. This is a hybrid position , combining remote medical oversight with regular on-site responsibilities across our network of clinical research sites. The PI will act as the medically accountable lead for assigned studies, ensuring trials are conducted to the highest scientific, ethical, and regulatory standards while safeguarding participant safety.
Key Responsibilities
Medical & Regulatory Oversight
- Serve as the Principal Investigator for clinical trials, providing overall medical leadership and accountability.
- Ensure strict compliance with study protocols, ICH-GCP, UK Clinical Trial Regulations, MHRA guidance, and local SOPs.
- Conduct or oversee medical eligibility assessments, patient histories, and trial-specific examinations (on-site as required).
- Review and sign off informed consent forms, patient safety data, and study documentation.
Participant Safety & Clinical Care
- Monitor participant safety throughout the duration of studies, making clinical decisions regarding treatment continuation or withdrawal.
- Report SAEs, SUSARs, and AEs in accordance with regulatory timelines.
- Act as the key medical contact for participant concerns, clinical queries, and emergency oversight.
Leadership & Collaboration
- Provide guidance and mentorship to research staff, including sub-investigators, nurses, and coordinators.
- Build strong relationships with sponsors, CROs, and regulators.
- Participate in site selection, feasibility assessments, and audits .
Hybrid Work Model
- Remote responsibilities include: protocol review, safety oversight, medical queries, and teleconferences with sponsors/CROs.
- On-site responsibilities (at least 1–2 days per week, depending on study requirements) include: patient assessments, staff training, monitoring visits, and audits.
Qualifications & Experience
- Medical degree (MBBS/MBChB or equivalent) with full GMC registration and licence to practise in the UK.
- Previous experience as a Principal Investigator and Sub-Investigator required, but experienced clinicians with a strong interest in research will also be considered.
- Solid understanding of ICH-GCP, UK Clinical Trial Regulations, and MHRA requirements.
- Excellent leadership, communication, and organizational skills.
- Ability to balance remote work efficiency with on-site clinical commitments .
What We Offer
- Flexible hybrid working model (remote + site-based).
- Opportunity to lead high-impact clinical trials across a range of therapeutic areas.
- Professional development and training in clinical research leadership.
- Collaborative working culture with supportive multidisciplinary teams.
- Competitive salary and benefits package.
Key Competencies
- Clinical expertise and sound decision-making.
- Strong grasp of regulatory and ethical frameworks.
- Effective communication and team leadership.
- Adaptability to both virtual and on-site working environments.
- Commitment to patient-centred care and research excellence.
Principal Investigator - Remote UK employer: Barrington James
Contact Detail:
Barrington James Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Investigator - Remote UK
✨Tip Number 1
Network with professionals in the clinical research field, especially those who have experience as Principal Investigators. Attend relevant conferences or webinars to connect with potential colleagues and learn about the latest trends in clinical trials.
✨Tip Number 2
Familiarise yourself with the specific therapeutic areas that StudySmarter is focusing on. Tailoring your discussions and demonstrating knowledge in these areas during interviews can set you apart from other candidates.
✨Tip Number 3
Prepare to discuss your previous experiences as a Principal Investigator or Sub-Investigator in detail. Highlight specific challenges you faced and how you overcame them, showcasing your leadership and decision-making skills.
✨Tip Number 4
Stay updated on the latest regulations and guidelines related to clinical trials in the UK. Being knowledgeable about ICH-GCP and MHRA requirements will demonstrate your commitment to compliance and participant safety during the interview process.
We think you need these skills to ace Principal Investigator - Remote UK
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience as a Principal Investigator or Sub-Investigator. Emphasise your medical qualifications, leadership roles, and any specific clinical trials you've overseen.
Craft a Strong Cover Letter: In your cover letter, express your passion for clinical research and detail how your experience aligns with the responsibilities outlined in the job description. Mention your understanding of ICH-GCP and UK Clinical Trial Regulations.
Highlight Leadership Skills: Since the role requires strong leadership and collaboration, provide examples of how you've successfully led teams or mentored staff in previous positions. This will demonstrate your capability to guide research staff effectively.
Showcase Adaptability: Discuss your ability to balance remote work with on-site responsibilities. Provide examples of how you've managed similar hybrid roles in the past, ensuring you convey your flexibility and commitment to participant safety.
How to prepare for a job interview at Barrington James
✨Showcase Your Medical Expertise
As a Principal Investigator, your medical knowledge is crucial. Be prepared to discuss your qualifications, including your medical degree and any relevant experience as a PI or Sub-Investigator. Highlight specific examples of how you've ensured compliance with ICH-GCP and UK Clinical Trial Regulations in past roles.
✨Demonstrate Leadership Skills
This role requires strong leadership and mentorship abilities. Share experiences where you've guided research staff or collaborated with multidisciplinary teams. Discuss how you build relationships with sponsors and CROs, as well as your approach to site selection and feasibility assessments.
✨Emphasise Participant Safety
Participant safety is paramount in clinical trials. Be ready to explain your strategies for monitoring participant safety and making clinical decisions regarding treatment. Provide examples of how you've handled serious adverse events (SAEs) and maintained communication with participants during trials.
✨Prepare for Hybrid Work Discussions
Since this position involves both remote and on-site responsibilities, be prepared to discuss how you manage your time effectively between these environments. Share your experience with remote oversight, protocol reviews, and how you ensure that on-site visits are productive and compliant with study protocols.
