At a Glance
- Tasks: Lead innovative gene therapy programs in neurological diseases and drive clinical operations.
- Company: Stealth mode TechBio company focused on high growth and innovation.
- Benefits: Competitive salary, annual bonus, stock options, and hybrid work model.
- Other info: Dynamic role with opportunities to integrate AI solutions and build new capabilities.
- Why this job: Make a real impact in healthcare by advancing groundbreaking therapies for neurological conditions.
- Qualifications: 10+ years in clinical operations with experience in Phase II/III trials, preferably in biotech.
The predicted salary is between 120000 - 150000 £ per year.
Location: Hybrid. Three days a week in central London office
Compensation: Base salary between £120,000 - £150,000 + annual bonus and meaningful stock options in high growth business.
We are currently partnered with a stealth mode TechBio company to help them appoint an experienced operational leader to drive delivery across their innovative gene therapy programs in neurological and psychiatric diseases, initially focused on Parkinson's disease with the plan to explore additional indications.
Reporting directly to the C-Suite, the Clinical Operations Lead will be responsible for leading their late stage asset through the rest of development and into market entry and a potential asset sale, combining strong clinical development and operational expertise with an entrepreneurial, technology driven mindset.
This is a highly empowered role for someone who looks beyond traditional clinical operations and is motivated by creating success across the full product lifecycle, focusing on high quality clinical execution while also supporting with trial related insights that can serve regulators, payers, physicians and HTA bodies.
The ideal candidate is decisive, accountable and comfortable navigating in a high energy, high growth and driven environment who is excited to build new capabilities rather than simply maintain existing processes. You will bring the expertise of an experienced drug developer with the curiosity and openness of embedding AI solutions to improve success and timelines.
Responsibilities- Clinical Set-up and Execution
- Support trial design, planning and setup including vendor, country and site selection
- Ensure the timely and accurate completion of necessary regulatory applications across jurisdictions, including Health authorities, as well as GMO bodies, IRBs, site-specific committees and others
- Drive the operational management and execution of clinical development programs in a hands-on, highly organized and proactive manner
- Oversee, monitor and control CROs, vendors, and study teams to ensure high-quality delivery, timeline adherence, budget control and operational excellence
- Anticipate operational risks and bottlenecks, and implement pragmatic solutions to maintain program momentum and delivery timelines
- Engage with investigators and site personnel to drive strong patient recruitment
- Ensure the integrity and quality of clinical trial data, oversee data reconciliation, support safety surveillance, support data quality and consistency assessments and contribute to safety review committees
- Align & engage with our development partners throughout the different programs
- Innovation & Healthcare Technology
- Challenge conventional approaches and identify opportunities to accelerate clinical development while maintaining high trial quality
- Evaluate and integrate emerging AI solutions and innovative operational approaches (direct or through vendors) to optimise trial execution, patient enrolment, trial management, and safety monitoring
- Explore and advance innovative clinical trial strategies and technologies, including proactive engagement with regulators and stakeholders to support adoption
- Program Strategy
- Drive program management and trial execution with a forward-looking mindset, supporting early evidence for registration, reimbursement, payer discussion and commercial launch
- Identify practical opportunities within the phase III program to generate launch-relevant insights, including patient journey, treatment patterns, endpoint optimisation, site feedback, and real-world evidence opportunities
- Lead structured KME/site engagement to build scientific advocacy, understand adoption barriers, and strengthen launch readiness from the clinical program onward
- 10+ years of relevant experience in clinical operations, clinical development operations, or clinical program leadership within biotech, pharma, or CRO environments
- Demonstrated experience leading Phase II/III or pivotal clinical trials, ideally in multi-country or global settings
- Proven ability to manage CROs, vendors, site coordination, budgets, timelines, risks, and quality deliverables in a hands-on, solution-oriented manner
- Ideally experienced with running late stage clinical trials within the CNS Therapeutic area, and experience with Cell and Gene Therapies is advantageous.
- Experience in a small biotech or high growth environment would be seen as a bonus. It's not essential, but the environment would be very different to that of large pharma or top 5 CRO.
To discuss this opportunity further please reach out to Chris Gibson on cgibson@barringtonjames.com
Director Clinical Operations in London employer: Barrington James
As a pioneering TechBio company located in the heart of London, we offer an empowering work environment that fosters innovation and collaboration. Our commitment to employee growth is reflected in our competitive compensation package, including meaningful stock options and annual bonuses, alongside a culture that encourages creativity and the integration of cutting-edge AI solutions in clinical operations. Join us to be part of a dynamic team dedicated to transforming healthcare through groundbreaking gene therapy programs, where your contributions will directly impact patient lives and the future of medicine.
StudySmarter Expert Advice🤫
We think this is how you could land Director Clinical Operations in London
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotech and pharma sectors. Attend industry events or webinars where you can meet potential employers and showcase your expertise in clinical operations.
✨Tip Number 2
Prepare for interviews by brushing up on your knowledge of gene therapy and CNS diseases. Be ready to discuss how your experience aligns with the innovative approaches the company is taking, especially around AI solutions.
✨Tip Number 3
Showcase your leadership skills! During interviews, share specific examples of how you've driven successful clinical trials and managed teams effectively. Highlight your ability to navigate high-energy environments.
✨Tip Number 4
Don’t forget to apply through our website! It’s a great way to ensure your application gets noticed. Plus, we love seeing candidates who are proactive about their job search.
We think you need these skills to ace Director Clinical Operations in London
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Director Clinical Operations role. Highlight your experience in clinical operations, especially with Phase II/III trials and any relevant CNS or gene therapy work. We want to see how your background aligns with our innovative approach!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you're excited about this role and how your entrepreneurial mindset can drive success in our high-growth environment. Let us know how you challenge conventional approaches in clinical development.
Showcase Your Leadership Skills:As a potential leader, we want to see examples of how you've managed teams and projects in the past. Share specific instances where you've driven operational excellence and navigated challenges in clinical trials. We love a proactive problem-solver!
Apply Through Our Website:Don't forget to apply through our website! It’s the best way for us to receive your application and ensures you’re considered for this exciting opportunity. We can't wait to see what you bring to the table!
How to prepare for a job interview at Barrington James
✨Know Your Stuff
Make sure you thoroughly understand the company’s focus on gene therapy, especially in CNS. Brush up on the latest advancements in Parkinson's disease treatments and be ready to discuss how your experience aligns with their innovative approach.
✨Showcase Your Leadership Skills
As a Director of Clinical Operations, you'll need to demonstrate your ability to lead teams effectively. Prepare examples of how you've successfully managed CROs and vendors, ensuring high-quality delivery and adherence to timelines in previous roles.
✨Be Ready for Problem-Solving
Expect questions about how you handle operational risks and bottlenecks. Think of specific instances where you implemented pragmatic solutions to maintain program momentum and be prepared to share these stories.
✨Embrace Innovation
This role requires a forward-thinking mindset, especially regarding AI solutions in clinical trials. Be ready to discuss how you've integrated innovative technologies in past projects and how you envision doing so in this new role.
