Barrington James is supporting an emerging biotechnology company that is looking to appoint a senior preclinical development leader to support the progression of antibody-based therapeutic programmes towards clinical development. This is a hands-on strategic role for someone with strong in vivo pharmacology and preclinical development experience, who can help shape the right study strategy from early proof-of-concept through IND/CTA-enabling activity. Key Responsibilities Lead preclinical strategy across early-stage antibody therapeutic programmes. Design, oversee and interpret in vivo pharmacology, PK/PD, toxicology and safety studies. Provide input on disease model selection, species relevance, endpoints, dose rationale and translational value Manage outsourced studies with CROs, consultants and external study directors Interpret complex in vivo and toxicology data, identifying key risks, limitations and next steps Work cross-functionally with discovery, translational, CMC, regulatory and clinical stakeholders Support candidate selection and IND/CTA-enabling documentation Experience Required Strong background in in vivo pharmacology, preclinical development or nonclinical strategy Experience progressing antibody-based, biologic or complex therapeutic programmes towards IND/CTA or early clinical development Strong understanding of animal model selection, pharmacology study design, PK/PD, toxicology and translational interpretation Experience managing external CROs and outsourced in vivo studies Ability to challenge study design, interpret complex data and translate findings into clear development recommendations.
