At a Glance
- Tasks: Lead the development of next-gen gene-editing therapeutics in a hands-on lab role.
- Company: Join a pioneering biotech firm focused on precision medicine.
- Benefits: Competitive salary, health benefits, and opportunities for professional growth.
- Other info: Fast-paced environment with exciting challenges and career advancement opportunities.
- Why this job: Make a real impact in advancing innovative therapies using CRISPR technology.
- Qualifications: M.S. or Ph.D. in relevant fields with extensive molecular cloning experience.
The predicted salary is between 50000 - 70000 £ per year.
Seeking a highly motivated scientist to lead the engineering and development of next-generation programmable gene‑editing therapeutics. This is a hands‑on laboratory role focused on designing, building, and optimizing CRISPR‑based therapeutic constructs for precision medicine applications. The successful candidate will play a key role in advancing novel therapeutic candidates from concept through preclinical development.
Responsibilities
- Design, engineer, and optimize Cas‑based therapeutic constructs, including conditional and programmable protein architectures.
- Engineer proteins for enhanced specificity, activity, and control using rational design, structure‑guided engineering, and directed evolution.
- Expand the modularity of the platform by developing constructs targeting additional disease‑relevant genes.
- Design, clone, and validate guide RNA libraries for specificity and off‑target profiling assays (e.g., ONE‑seq, CHANGE‑seq, or related technologies).
- Design, execute, and analyze rapid design‑build‑test cycles to improve construct performance.
- Collaborate across molecular biology, protein engineering, computational biology, and translational research teams to advance therapeutic programs.
Required Qualifications
- M.S. or Ph.D. in Molecular Biology, Genetics, Bioengineering, Protein Engineering, or a related field.
- At least 5 years of hands‑on experience in molecular cloning using techniques such as Gibson Assembly, Golden Gate Assembly, and Gateway cloning.
- Extensive experience designing and engineering CRISPR/Cas constructs, including development of novel protein functions through directed evolution or rational engineering.
- Strong expertise in mammalian and bacterial expression vector design, construct optimization, and stable cell line generation.
- Demonstrated ability to independently execute rapid iterative construct design and optimization.
- Experience developing and utilizing fluorescent and/or luminescent reporter assay systems.
- Strong structural biology and wet‑lab expertise, with experience applying structural insights to protein engineering challenges.
- Demonstrated ownership of engineering protein function, rather than solely supporting execution of established workflows.
- Computational experience supporting protein or CRISPR engineering, including sequence analysis, structural modeling, guide RNA design, scripting, or bioinformatics.
Preferred Qualifications
- Experience with inducible or conditional protein systems.
- Familiarity with base editing, prime editing, or other next‑generation genome editing technologies.
- Experience with NGS library preparation and sequencing‑based screening workflows.
- Background in structural biology, protein biochemistry, or computational protein engineering.
- Experience working in fast‑paced biotechnology or therapeutic discovery environments.
Molecular Cloning & Protein Engineering Scientist in London employer: Barrington James Limited
Join a pioneering biotechnology company that is at the forefront of gene-editing therapeutics, where your expertise as a Molecular Cloning & Protein Engineering Scientist will directly contribute to groundbreaking advancements in precision medicine. Our collaborative work culture fosters innovation and creativity, providing ample opportunities for professional growth and development in a dynamic laboratory environment. Located in a vibrant scientific community, we offer competitive benefits and a commitment to employee well-being, making us an exceptional employer for those seeking meaningful and impactful work.
StudySmarter Expert Advice🤫
We think this is how you could land Molecular Cloning & Protein Engineering Scientist in London
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
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✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like Barrington James Limited!
We think you need these skills to ace Molecular Cloning & Protein Engineering Scientist in London
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Barrington James Limited that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Barrington James Limited.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Barrington James Limited does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Barrington James Limited
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Barrington James Limited. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into Barrington James Limited's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Barrington James Limited. This shows your passion for the industry!
