The role will focus on the development and execution of in vivo potency assays and safety studies, with particular emphasis on CNS/neuroscience and ocular/retinal research.
Key Responsibilities
- Design, develop and execute in vivo gene therapy potency and safety studies.
- Support gene therapy programmes from early discovery through to clinical development.
- Develop and optimise AAV-based therapeutic assays and readouts.
- Work with multidisciplinary R&D, quality and compliance teams.
- Develop and improve laboratory processes, workflows and technologies.
- Design and write SOPs, work instructions and experimental protocols.
- Support technology transfer and implementation of process improvements.
- Contribute to the development of a growing R&D laboratory facility.
- Deliver experiments within agreed timelines, budgets and quality standards.
- Strong experience in molecular biology, including techniques such as DNA/RNA extraction, dPCR and Western blotting.
- Proven in vivo research experience within CNS/neuroscience, brain or retinal/ocular models.
- Experience with AAV-based gene therapy and relevant therapeutic readouts.
- Experience with histology, including cryosectioning and immunohistochemistry.
- Strong understanding of experimental design and process development/validation.
- Experience developing, evaluating and implementing new techniques or technologies.
- Experience working with small animal models; previous/current Home Office personal licence experience would be advantageous.
- Ability to work effectively in a multidisciplinary, controlled research environment.
The Ideal Candidate
We are looking for a scientist who combines strong hands-on molecular biology and in vivo expertise with the ability to develop assays, troubleshoot experiments and improve existing processes.
You should be comfortable working independently, managing experimental timelines and budgets, and communicating scientific findings clearly to both technical and non-technical colleagues.
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Research Scientist - Preclinical in London employer: Barrington James Drug Discovery & Preclinical
As a leading research facility in the heart of the biotech sector, we pride ourselves on fostering a collaborative and innovative work culture that empowers our employees to excel. Our commitment to professional development is evident through tailored training programmes and opportunities for career advancement, ensuring that our Research Scientists can thrive in their roles while contributing to groundbreaking advancements in gene therapy. With state-of-the-art laboratories and a focus on cutting-edge research, we offer a unique environment where your contributions will make a meaningful impact on the future of healthcare.
Contact Details:
Barrington James Drug Discovery & Preclinical Recruitment Team
